The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Activation of Innate Immunity Is Required for Efficient Nuclear Reprogramming
Open accessAbstract
Retroviral overexpression of reprogramming factors (Oct4, Sox2, Klf4, c-Myc) generates induced pluripotent stem cells (iPSCs). However, the integration of foreign DNA could induce genomic dysregulation. Cell-permeant proteins (CPPs) could overcome this limitation. To date this approach has proved exceedingly inefficient. We discovered a striking difference in the pattern of gene expression induced by viral versus CPP-based delivery of the reprogramming factors, suggesting that a signaling pathway required for efficient nuclear reprogramming was activated by the retroviral, but not CPP approach. In gain- and loss-of function studies, we find that the toll-like receptor 3 (TLR3) pathway enables efficient induction of pluripotency by viral or mmRNA approaches. Stimulation of TLR3 causes rapid and global changes in the expression of epigenetic modifiers to enhance chromatin remodeling and nuclear reprogramming. Activation of inflammatory pathways are required for efficient nuclear reprogramming in the induction of pluripotency.
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Cites
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Epigenetic modulators, modifiers and mediators in cancer aetiology and progression
Feinberg, A. P., Koldobskiy, M. A., & Göndör, A. (2016) · Nature Reviews Genetics · doi:10.1038/nrg.2016.13 · Cited by 841
Mending broken hearts: cardiac development as a basis for adult heart regeneration and repair
Xin, M., Olson, E. N., & Bassel-Duby, R. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3619 · Cited by 514
Inflammation in intervertebral disc degeneration and regeneration
Molinos, M., Almeida, C. R., Caldeira, J., Cunha, C., Gonçalves, R. M., & Barbosa, M. A. (2015) · Journal of The Royal Society Interface · doi:10.1098/rsif.2014.1191 · Cited by 454
Efficient generation of human iPSCs by a synthetic self-replicative RNA
Yoshioka, N., Gros, E., Li, H.-R., Kumar, S., Deacon, D. C., Maron, C., Muotri, A. R., Chi, N. C., Fu, X.-D., Yu, B. D., et al. (2013) · Cell stem cell · doi:10.1016/j.stem.2013.06.001 · Cited by 312
Stem Cell-Derived Extracellular Vesicles and Immune-Modulation
Burrello, J., Monticone, S., Gai, C., Gomez, Y., Kholia, S., & Camussi, G. (2016) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2016.00083 · Cited by 266
Metadata
- Authors
- Lee, J., Sayed, N., Hunter, A., Au, K. F., Wong, W. H., Mocarski, E. S., Pera, R. R., Yakubov, E., & Cooke, J. P.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2012-10
- Volume
- 151
- Issue
- 3
- Pages
- 547-558
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2119656037
- Cited by
- 344
- References
- 45
- FWCI
- 13.13
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Lee, J., Sayed, N., Hunter, A., Au, K. F., Wong, W. H., Mocarski, E. S., Pera, R. R., Yakubov, E., & Cooke, J. P. (2012). Activation of Innate Immunity Is Required for Efficient Nuclear Reprogramming. Cell. https://doi.org/10.1016/j.cell.2012.09.034
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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