The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
STATs Shape the Active Enhancer Landscape of T Cell Populations
Open accessAbstract
SUMMARY Signaling pathways are intimately involved in cellular differentiation, allowing cells to respond to their environment by regulating gene expression. While enhancers are recognized as key elements that regulate selective gene expression, the interplay between signaling pathways and actively used enhancer elements is not clear. Here, we use CD4+ T cells as a model of differentiation, mapping the acquisition of cell-type-specific enhancer elements in T-helper 1 (Th1) and Th2 cells. Our data establish that STAT proteins have a major impact on the acquisition of lineage-specific enhancers and the suppression of enhancers associated with alternative cell fates. Transcriptome analysis further supports a functional role for enhancers regulated by STATs. Importantly, expression of lineage-defining master regulators in STAT-deficient cells fails to fully recover the chromatin signature of STAT-dependent enhancers. Thus, these findings point to a critical role of STATs as environmental sensors in dynamically molding the specialized enhancer architecture of differentiating cells.
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Evolutionarily conserved elements in vertebrate, insect, worm, and yeast genomes
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Functional and Mechanistic Diversity of Distal Transcription Enhancers
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T-bet is rapidly induced by interferon-γ in lymphoid and myeloid cells
Lighvani, A. A., Frucht, D. M., Jankovic, D., Yamane, H., Aliberti, J., Hissong, B. D., Nguyen, B. V., Gadina, M., Sher, A., Paul, W. E., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.261570598 · Cited by 783 · cited 2×
“The modest effect of STAT1 or STAT4 on H3K4me1 is not unexpected as both can contribute to Th1 specification, and mice lacking both these factors have not been generated (Lighvani et al., 2001; Thieu et al., 2008).”
Self-citationGhisletti, S., Barozzi, I., Mietton, F., Polletti, S., De Santa, F., Venturini, E., Gregory, L., Lonie, L., Chew, A., Wei, C.-L., et al. (2010) · Immunity · doi:10.1016/j.immuni.2010.02.008 · Cited by 666
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Cited by
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The IL-23-IL-17 immune axis: from mechanisms to therapeutic testing
Gaffen, S. L., Jain, R., Garg, A. V., & Cua, D. J. (2014) · Nature reviews. Immunology · doi:10.1038/nri3707 · Cited by 1,585
Mechanisms and consequences of Jak–STAT signaling in the immune system
Villarino, A. V., Kanno, Y., & O'Shea, J. J. (2017) · Nature Immunology · doi:10.1038/ni.3691 · Cited by 1,221
Self-citationThe selection and function of cell type-specific enhancers
Heinz, S., Romanoski, C. E., Benner, C., & Glass, C. K. (2015) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3949 · Cited by 1,010
Harnessing the plasticity of CD4+ T cells to treat immune-mediated disease
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Metadata
- Authors
- Vahedi, G., Takahashi, H., Nakayamada, S., Sun, H.-W., Sartorelli, V., Kanno, Y., & O’Shea, J. J.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2012-11
- Volume
- 151
- Issue
- 5
- Pages
- 981-993
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W1990233086
- Cited by
- 367
- References
- 11
- FWCI
- 14.52
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Vahedi, G., Takahashi, H., Nakayamada, S., Sun, H.-W., Sartorelli, V., Kanno, Y., & O’Shea, J. J. (2012). STATs Shape the Active Enhancer Landscape of T Cell Populations. Cell. https://doi.org/10.1016/j.cell.2012.09.044
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