The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.
Endocardial Cells Form the Coronary Arteries by Angiogenesis through Myocardial-Endocardial VEGF Signaling
Open accessAbstract
Summary The origins and developmental mechanisms of coronary arteries are incompletely understood. We showed here by fate mapping, clonal analysis and immunohistochemistry that endocardial cells generate the endothelium of coronary arteries. Dye tracking, live imaging, and tissue transplantation also revealed that ventricular endocardial cells are not terminally differentiated; instead, they are angiogenic and form coronary endothelial networks. Myocardial Vegf-a or endocardial Vegfr-2 deletion inhibited coronary angiogenesis and arterial formation by ventricular endocardial cells. In contrast, lineage and knockout studies showed that endocardial cells make a small contribution to the coronary veins, the formation of which is independent of myocardial-to-endocardial Vegf signaling. Thus, contrary to the current view of a common source for the coronary vessels, our findings indicate that the coronary arteries and veins have distinct origins and are formed by different mechanisms. This information may help develop better cell therapies for coronary artery disease.
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Cites
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Self-citationA Highly Efficient Recombineering-Based Method for Generating Conditional Knockout Mutations
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Metadata
- Authors
- Wu, B., Zhang, Z., Lui, W., Chen, X., Wang, Y., Chamberlain, A. A., Moreno-Rodriguez, R. A., Markwald, R. R., O’Rourke, B. P., Sharp, D. J., Zheng, D., Lenz, J., Baldwin, H. S., Chang, C.-P., & Zhou, B.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2012-11
- Volume
- 151
- Issue
- 5
- Pages
- 1083-1096
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2066287407
- Cited by
- 393
- References
- 50
- FWCI
- 8.71
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Wu, B., Zhang, Z., Lui, W., Chen, X., Wang, Y., Chamberlain, A. A., Moreno-Rodriguez, R. A., Markwald, R. R., O’Rourke, B. P., Sharp, D. J., Zheng, D., Lenz, J., Baldwin, H. S., Chang, C.-P., & Zhou, B. (2012). Endocardial Cells Form the Coronary Arteries by Angiogenesis through Myocardial-Endocardial VEGF Signaling. Cell. https://doi.org/10.1016/j.cell.2012.10.023
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
