Vascular endothelial cell development and diversity
Open accessAbstract
Vascular endothelial cells form the inner layer of blood vessels where they have a key role in the development and maintenance of the functional circulatory system and provide paracrine support to surrounding non-vascular cells. Technical advances in the past 5 years in single-cell genomics and in in vivo genetic labelling have facilitated greater insights into endothelial cell development, plasticity and heterogeneity. These advances have also contributed to a new understanding of the timing of endothelial cell subtype differentiation and its relationship to the cell cycle. Identification of novel tissue-specific gene expression patterns in endothelial cells has led to the discovery of crucial signalling pathways and new interactions with other cell types that have key roles in both tissue maintenance and disease pathology. In this Review, we describe the latest findings in vascular endothelial cell development and diversity, which are often supported by large-scale, single-cell studies, and discuss the implications of these findings for vascular medicine. In addition, we highlight how techniques such as single-cell multimodal omics, which have become increasingly sophisticated over the past 2 years, are being utilized to study normal vascular physiology as well as functional perturbations in disease.
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In disease states, most transcriptional changes occur within capillary beds and alveolar specialization is diminished in lung adenocarcinoma.
“In disease states, most transcriptional changes have been found to occur within capillary beds and in consistent, the alveolar specialization is diminished in lung adenocarcinoma9,10”
From Endothelial Pim3 kinase protects the vascular barrier during lung metastasis (2024) · cites this paper as [10]
In “Organ-specific findings at high resolution” (page not provided), the review reports that capillary endothelial cells had the most potentially pathological transcriptional changes in a comparison of bronchopulmonary dysplasia samples. It also reports loss of specialized aerocyte capillaries and emergence of an intermediate capillary population in a human lung adenocarcinoma sample. The claim extends the finding about where most changes occur beyond the specific disease comparison described. (LLM, conf=0.85)
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Endothelial cell metabolism in cardiovascular physiology and disease
Pasut, A., Lama, E., Van Craenenbroeck, A. H., Kroon, J., & Carmeliet, P. (2025) · Nature Reviews Cardiology · doi:10.1038/s41569-025-01162-x · Cited by 74 · see citing works
Endothelial Pim3 kinase protects the vascular barrier during lung metastasis
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- Authors
- Trimm, E., & Red-Horse, K.
- Affiliations
- Stanford Medicine (US)
- ORCID
- Trimm, Emily
- Venue
- Nature Reviews Cardiology
- Published
- 2022-10-05
- Volume
- 20
- Issue
- 3
- Pages
- 197-210
- ISSN
- 1759-5002 (ISSN-L)
- 1759-5010
- PMC
- PMC9533272
- OpenAlex
- W4301600652
- Cited by
- 537
- References
- 187
- Citations by year
- 2026: 143 · 2025: 196 · 2024: 162 · 2023: 34 · 2022: 2
- FWCI
- 10.46
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Nature Reviews Cardiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Hertz Foundation
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Single-cell and spatial transcriptomics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- vascular endothelial cells, endothelial cell development, endothelial heterogeneity, endothelial plasticity, endothelial differentiation, cell cycle, tissue-specific gene expression, single-cell RNA sequencing, brain endothelium, lung endothelium, liver endothelium
- MeSH terms
- Cell Differentiation, Humans, Signal Transduction, Endothelial Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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