Endothelial-Specific Cre Mouse Models: Is Your Cre CREdibile?

Generalized lacZ expression with the ROSA26 Cre reporter strain

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VEGF receptor signalling ? in control of vascular function

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Basic and Therapeutic Aspects of Angiogenesis

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Pericyte Loss and Microaneurysm Formation in PDGF-B-Deficient Mice

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Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation

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Role of PDGF-B and PDGFR-β in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse

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Efficient Recombination in Diverse Tissues by a Tamoxifen-Inducible Form of Cre: A Tool for Temporally Regulated Gene Activation/Inactivation in the Mouse

Hayashi, S., & McMahon, A. P. (2002) · Developmental Biology · doi:10.1006/dbio.2002.0597 · Cited by 1,347 · see citing works

Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis

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Tie2-Cre Transgenic Mice: A New Model for Endothelial Cell-Lineage Analysis in Vivo

Kisanuki, Y. Y., Hammer, R. E., Miyazaki, J.-I., Williams, S. C., Richardson, J. A., & Yanagisawa, M. (2001) · Developmental Biology · doi:10.1006/dbio.2000.0106 · Cited by 1,241 · see citing works

Molecular control of endothelial cell behaviour during blood vessel morphogenesis

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Runx1 is required for the endothelial to haematopoietic cell transition but not thereafter

Chen, M. J., Yokomizo, T., Zeigler, B. M., Dzierzak, E. A., & Speck, N. A. (2009) · Nature · doi:10.1038/nature07619 · Cited by 1,016 · see citing works

Regulation of Cre Recombinase Activity by Mutated Estrogen Receptor Ligand-Binding Domains

Feil, R., Wagner, J. D., METZGER, D., & Chambon, P. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.7124 · Cited by 992 · see citing works

Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryo.

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Adipose-specific peroxisome proliferator-activated receptor γ knockout causes insulin resistance in fat and liver but not in muscle

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Ligand-activated site-specific recombination in mice.

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Untitled work

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Bacteriophage P1 site-specific recombination

Sternberg, N. L., & Hamilton, D. L. (1981) · Journal of Molecular Biology · doi:10.1016/0022-2836(81)90375-2 · Cited by 791 · see citing works

Tissue- and site-specific DNA recombination in transgenic mice.

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The Mouse Retina as an Angiogenesis Model

Stahl, A., Connor, K. M., Sapieha, P. S., Chen, J., Dennison, R. J., Krah, N. M., Seaward, M. R., Willett, K. L., Aderman, C. M., Guerin, K. I., et al. (2010) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.10-5176 · Cited by 610 · see citing works

Growth inhibition and DNA damage induced by Cre recombinase in mammalian cells

Loonstra, A., Vooijs, M., Beverloo, H. B., Allak, B. A., van Drunen, E., Kanaar, R., Berns, A. J. M., & Jonkers, J. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.161269798 · Cited by 591 · see citing works

Lineage tracing demonstrates the venous origin of the mammalian lymphatic vasculaturePreprint

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FOXO1 couples metabolic activity and growth state in the vascular endothelium

Wilhelm, K., Happel, K., Eelen, G., Schoors, S., Oellerich, M. F., Lim, R., Zimmermann, B., Aspalter, I. M., Franco, C. A., Boettger, T., et al. (2016) · Nature · doi:10.1038/nature16498 · Cited by 579 · see citing works

Conditional Vascular Cell Adhesion Molecule 1 Deletion in Mice

Koni, P. A., Joshi, S. K., Temann, U.-A., Olson, D. L., Burkly, L. C., & Flavell, R. A. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.193.6.741 · Cited by 482 · see citing works

Identification and functional analysis of endothelial tip cell–enriched genes

del Toro, R., Prahst, C., Mathivet, T., Siegfried, G., Kaminker, J. S., Larrivee, B., Breant, C., Duarte, A., Takakura, N., Fukamizu, A., et al. (2010) · Blood · doi:10.1182/blood-2010-02-270819 · Cited by 474 · see citing works

Uniform vascular-endothelial-cell-specific gene expression in both embryonic and adult transgenic mice

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VE‐Cadherin‐Cre‐recombinase transgenic mouse: A tool for lineage analysis and gene deletion in endothelial cells

Alva, J. A., Zovein, A. C., Monvoisin, A., Murphy, T. J., Salazar, A., Harvey, N. L., Carmeliet, P., & Iruela‐Arispe, M. L. (2006) · Developmental Dynamics · doi:10.1002/dvdy.20643 · Cited by 455 · see citing works

DLL1-mediated Notch activation regulates endothelial identity in mouse fetal arteries

Sörensen, I., Adams, R. H., & Gossler, A. (2009) · Blood · doi:10.1182/blood-2008-08-174508 · Cited by 451 · see citing works

Universal GFP reporter for the study of vascular development

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Tie2 Expression and Phosphorylation in Angiogenic and Quiescent Adult Tissues

Wong, A. L., Haroon, Z. A., Werner, S., Dewhirst, M. W., Greenberg, C. S., & Peters, K. G. (1997) · Circulation Research · doi:10.1161/01.res.81.4.567 · Cited by 417 · see citing works

tek, a novel tyrosine kinase gene located on mouse chromosome 4, is expressed in endothelial cells and their presumptive precursors.

Dumont, D., Yamaguchi, T. P., Conlon, R. A., Rossant, J., & Breitman, M. L. (1992) · PubMed · Cited by 410 · see citing works

Codon‐improved Cre recombinase (iCre) expression in the mouse

Shimshek, D. R., Kim, J., Hübner, M., Spergel, D. J., Buchholz, F., Casanova, E., Stewart, A. F., SEEBURG, P. H., & Sprengel, R. (2002) · genesis · doi:10.1002/gene.10023 · Cited by 398 · see citing works

Dll4 and Notch signalling couples sprouting angiogenesis and artery formation

Pitulescu, M. E., Schmidt, I., Giaimo, B. D., Antoine, T., Berkenfeld, F., Ferrante, F., Park, H., Ehling, M., Biljes, D., Rocha, S. F., et al. (2017) · Nature Cell Biology · doi:10.1038/ncb3555 · Cited by 397 · see citing works

Endocardial Cells Form the Coronary Arteries by Angiogenesis through Myocardial-Endocardial VEGF Signaling

Wu, B., Zhang, Z., Lui, W., Chen, X., Wang, Y., Chamberlain, A. A., Moreno‐Rodriguez, R. A., Markwald, R. R., O'Rourke, B. P., Sharp, D. J., et al. (2012) · Cell · doi:10.1016/j.cell.2012.10.023 · Cited by 394 · see citing works

Mechanical strain induces growth of vascular smooth muscle cells via autocrine action of PDGF.

Wilson, E., Mai, Q., Sudhir, K., Weiss, R. H., & Ives, H. E. (1993) · The Journal of Cell Biology · doi:10.1083/jcb.123.3.741 · Cited by 364 · see citing works

PDGF A-chain gene is expressed by mammalian neurons during development and in maturity

Yeh, H.-J., Ruit, K. G., Wang, Y.-X., Parks, W. C., Snider, W. D., & Deuel, T. F. (1991) · Cell · doi:10.1016/0092-8674(91)90222-k · Cited by 364 · see citing works

Improved reporter strain for monitoring Cre recombinase-mediated DNA excisions in mice

Mao, X., Fujiwara, Y., & Orkin, S. H. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.9.5037 · Cited by 332 · see citing works

P1 site-specific recombination: nucleotide sequence of the recombining sites.

Hoess, R. H., Ziese, M., & Sternberg, N. L. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.11.3398 · Cited by 330 · see citing works

Fatty acid binding protein 4 is a target of VEGF and a regulator of cell proliferation in endothelial cells

Elmasri, H., Karaaslan, Ç., Teper, Y., Ghelfi, E., Weng, M., Ince, T. A., Kozakewich, H. P., Bischoff, J. E., & Çataltepe, S. (2009) · The FASEB Journal · doi:10.1096/fj.09-134882 · Cited by 328 · see citing works

Efficient, inducible Cre‐recombinase activation in vascular endothelium

Claxton, S., Kostourou, V., Jadeja, S., Chambon, P., Hodivala‐Dilke, K., & Fruttiger, M. (2008) · genesis · doi:10.1002/dvg.20367 · Cited by 327 · see citing works

Neurons Limit Angiogenesis by Titrating VEGF in Retina

Okabe, K., Kobayashi, S., Yamada, T., Kurihara, T., Tai-Nagara, I., Miyamoto, T. K., Mukouyama, Y., Sato, T. N., Suda, T., Ema, M., et al. (2014) · Cell · doi:10.1016/j.cell.2014.09.025 · Cited by 313 · see citing works

Sox17 is indispensable for acquisition and maintenance of arterial identity

Corada, M., Orsenigo, F., Morini, M. F., Pitulescu, M. E., Bhat, G. P., Nyqvist, D., Breviario, F., Conti, V., Briot, A., Iruela‐Arispe, M. L., et al. (2013) · Nature Communications · doi:10.1038/ncomms3609 · Cited by 301 · see citing works

Bacterial artificial chromosome libraries for mouse sequencing and functional analysis.

Osoegawa, K., Tateno, M., Woon, P. Y., Frengen, E., Mammoser, A. G., Catanese, J. J., Hayashizaki, Y., & de Jong, P. J. (2000) · PubMed Central · Cited by 299 · see citing works

Arterial versus venous endothelial cells

Paz, N. G. D., & D'Amore, P. A. (2008) · Cell and Tissue Research · doi:10.1007/s00441-008-0706-5 · Cited by 293 · see citing works

VE-cadherin: at the front, center, and sides of endothelial cell organization and function

Harris, E. S., & Nelson, W. J. (2010) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2010.07.006 · Cited by 287 · see citing works

Microarray analysis of retinal endothelial tip cells identifies CXCR4 as a mediator of tip cell morphology and branching

Strasser, G. A., Kaminker, J. S., & Tessier‐Lavigne, M. (2010) · Blood · doi:10.1182/blood-2009-07-230284 · Cited by 284 · see citing works

Inducible Cre Mice

Feil, S. C., Valtcheva, N., & Feil, R. (2009) · Methods in molecular biology · doi:10.1007/978-1-59745-471-1_18 · Cited by 268 · see citing works

Cardiovascular ephrinB2 function is essential for embryonic angiogenesis

Gerety, S. S., & Anderson, D. J. (2002) · Development · doi:10.1242/dev.129.6.1397 · Cited by 263 · see citing works

VE‐cadherin‐CreER T2 transgenic mouse: A model for inducible recombination in the endothelium

Monvoisin, A., Alva, J. A., Hofmann, J. J., Zovein, A. C., Lane, T. F., & Iruela‐Arispe, M. L. (2006) · Developmental Dynamics · doi:10.1002/dvdy.20982 · Cited by 255 · see citing works

Esm1 Modulates Endothelial Tip Cell Behavior and Vascular Permeability by Enhancing VEGF Bioavailability

Rocha, S. F., Schiller, M., Jing, D., Li, H., Butz, S., Vestweber, D., Biljes, D., Drexler, H. C. A., Nieminen-Kelhä, M., Vajkoczy, P., et al. (2014) · Circulation Research · doi:10.1161/circresaha.115.304718 · Cited by 246 · see citing works

Endothelial FAK is essential for vascular network stability, cell survival, and lamellipodial formation

Braren, R., Hu, H., Kim, Y. H., Beggs, H. E., Reichardt, L. F., & Wang, R. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200506184 · Cited by 244 · see citing works

cKit Lineage Hemogenic Endothelium-Derived Cells Contribute to Mesenteric Lymphatic Vessels

Stanczuk, L., Martínez‐Corral, I., Ulvmar, M. H., Zhang, Y., Laviña, B., Fruttiger, M., Adams, R. H., Saur, D., Betsholtz, C., Ortega, S., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.02.026 · Cited by 238 · see citing works

The sinus venosus contributes to coronary vasculature through VEGFC-stimulated angiogenesis

Chen, H. I., Sharma, B., Akerberg, B. N., Nurmi, H. J., Kivelä, R., Saharinen, P., Aghajanian, H. K., McKay, A. S., Bogard, P. E., Chang, A. H., et al. (2014) · Development · doi:10.1242/dev.113639 · Cited by 234 · see citing works

Endothelial permeability and VE-cadherin

Gavard, J. (2014) · Cell Adhesion & Migration · doi:10.4161/cam.29026 · Cited by 233 · see citing works

Supporting conditional mouse mutagenesis with a comprehensive cre characterization resource

Heffner, C. S., Pratt, C. H., Babiuk, R. P., Sharma, Y., Rockwood, S. F., Donahue, L. R., Eppig, J. T., & Murray, S. A. (2012) · Nature Communications · doi:10.1038/ncomms2186 · Cited by 230 · see citing works

Detecting and Avoiding Problems When Using the Cre/lox System

Song, A. J., & Palmiter, R. (2018) · Trends in Genetics · doi:10.1016/j.tig.2017.12.008 · Cited by 227 · see citing works

Arteries are formed by vein-derived endothelial tip cells

Xu, C., Hasan, S. S., Schmidt, I., Rocha, S. F., Pitulescu, M. E., Bussmann, J., Meyen, D., Raz, E., Adams, R. H., & Siekmann, A. F. (2014) · Nature Communications · doi:10.1038/ncomms6758 · Cited by 225 · see citing works

Identification of vascular endothelial growth factor (VEGF) receptor-2 (Flk-1) promoter/enhancer sequences sufficient for angioblast and endothelial cell-specific transcription in transgenic mice

Kappel, A., Rönicke, V., Damert, A., Flamme, I., Risau, W., & Breier, G. (1999) · Blood · doi:10.1182/blood.v93.12.4284 · Cited by 223 · see citing works

Notch controls retinal blood vessel maturation and quiescence

Ehling, M., Adams, S., Benedito, R., & Adams, R. H. (2013) · Development · doi:10.1242/dev.093351 · Cited by 223 · see citing works

De novo formation of a distinct coronary vascular population in neonatal heart

Tian, X., Hu, T., Zhang, H., He, L., Huang, X., Liu, Q., Yu, W., He, L., Yang, X. Y., Yan, Y., et al. (2014) · Science · doi:10.1126/science.1251487 · Cited by 216 · see citing works

Size-selective opening of the blood–brain barrier by targeting endothelial sphingosine 1–phosphate receptor 1

Yanagida, K., Liu, C. H., Faraco, G., Galvani, S., Smith, H. K., Burg, N. D., Anrather, J., Sánchez, T., Iadecola, C., & Hla, T. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1618659114 · Cited by 213 · see citing works

Subepicardial endothelial cells invade the embryonic ventricle wall to form coronary arteries

Tian, X., Hu, T., Zhang, H., He, L., Huang, X., Liu, Q., Yu, W., He, L., Yang, Z., Zhang, Z., et al. (2013) · Cell Research · doi:10.1038/cr.2013.83 · Cited by 205 · see citing works

Cellular Origin and Developmental Program of Coronary Angiogenesis

Tian, X., Pu, W. T., & Zhou, B. (2015) · Circulation Research · doi:10.1161/circresaha.116.305097 · Cited by 184 · see citing works

The endothelial-specific receptor tyrosine kinase, tek, is a member of a new subfamily of receptors.

Dumont, D., Gradwohl, G., Fong, G.-H., Auerbach, R., & Breitman, M. L. (1993) · PubMed · Cited by 181 · see citing works

The contribution of the Tie2 + lineage to primitive and definitive hematopoietic cells

Tang, Y., Harrington, A. N., Yang, X., Friesel, R. E., & Liaw, L. (2010) · genesis · doi:10.1002/dvg.20654 · Cited by 179 · see citing works

Impaired adipogenesis and lipolysis in the mouse upon selective ablation of the retinoid X receptor α mediated by a tamoxifen-inducible chimeric Cre recombinase (Cre-ER T2 ) in adipocytes

Imai, T., Jiang, M., Chambon, P., & METZGER, D. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.1.224 · Cited by 171 · see citing works

Heterogeneity in the lymphatic vascular system and its origin

Ulvmar, M. H., & Mäkinen, T. (2016) · Cardiovascular Research · doi:10.1093/cvr/cvw175 · Cited by 169 · see citing works

The molecular regulation of arteriovenous specification and maintenance

Fish, J. E., & Wythe, J. D. (2015) · Developmental Dynamics · doi:10.1002/dvdy.24252 · Cited by 164 · see citing works

Endothelial Cells Require STAT3 for Protection against Endotoxin-induced Inf lammation

Kano, A., Wolfgang, M. J., Gao, Q., Jacoby, J. J., Chai, G.-X., Hansen, W. R., Iwamoto, Y., Pober, J. S., Flavell, R. A., & Fu, X.-Y. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030077 · Cited by 163 · see citing works

DNA recombination with a heterospecific Cre homolog identified from comparison of the pac-c1 regions of P1-related phages

Sauer, B. (2004) · Nucleic Acids Research · doi:10.1093/nar/gkh941 · Cited by 155 · see citing works

Rapid engineering of bacterial artificial chromosomes using oligonucleotides

Swaminathan, S., Ellis, H. M., Waters, L. S., Yu, D., Lee, E.-C., Court, D. L., & Sharan, S. K. (2000) · genesis · doi:10.1002/1526-968x(200101)29:1 · Cited by 154 · see citing works

Endocardium Minimally Contributes to Coronary Endothelium in the Embryonic Ventricular Free Walls

Zhang, H., Pu, W., Li, G., Huang, X., He, L., Tian, X., Liu, Q., Zhang, L., Wu, S. M., Sucov, H. M., et al. (2016) · Circulation Research · doi:10.1161/circresaha.116.308749 · Cited by 149 · see citing works

Genetic targeting of sprouting angiogenesis using Apln-CreER

Liu, Q., Hu, T., He, L., Huang, X., Tian, X., Zhang, H., He, L., Pu, W., Zhang, L., Sun, H., et al. (2015) · Nature Communications · doi:10.1038/ncomms7020 · Cited by 136 · see citing works

Temporal Cre‐mediated recombination exclusively in endothelial cells using Tie2 regulatory elements

Forde, A., Constien, R., Gröne, H., Hämmerling, G. J., & Arnold, B. (2002) · genesis · doi:10.1002/gene.10117 · Cited by 128 · see citing works

VEGFR3 does not sustain retinal angiogenesis without VEGFR2

Zarkada, G., Heinolainen, K., Mäkinen, T., Kubota, Y., & Alitalo, K. K. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1423278112 · Cited by 127 · see citing works

Endocardial Cell Plasticity in Cardiac Development, Diseases and Regeneration

Zhang, H., Lui, K. O., & Zhou, B. (2018) · Circulation Research · doi:10.1161/circresaha.117.312136 · Cited by 127 · see citing works

The Vascular Endothelial-Cadherin Promoter Directs Endothelial-Specific Expression in Transgenic Mice

Gory‐Fauré, S., Vernet, M., Laurent, M., Dejana, E., Dalmon, J., & Huber, P. (1999) · Blood · doi:10.1182/blood.v93.1.184 · Cited by 125 · see citing works

Relevance of BAC transgene copy number in mice: transgene copy number variation across multiple transgenic lines and correlations with transgene integrity and expression

Chandler, K. J., Chandler, R. L., Broeckelmann, E. M., Hou, Y., Southard‐Smith, E. M., & Mortlock, D. P. (2007) · Mammalian Genome · doi:10.1007/s00335-007-9056-y · Cited by 120 · see citing works

Impaired adipogenesis and lipolysis in the mouse upon selective ablation of the retinoid X receptor alpha mediated by a tamoxifen-inducible chimeric Cre recombinase (Cre-ERT2) in adipocytes

Imai, T. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.011528898 · Cited by 119 · see citing works

Non-parallel recombination limits Cre-LoxP-based reporters as precise indicators of conditional genetic manipulation

Liu, J., Willet, S. G., Bankaitis, E., Xu, Y., Wright, C., & Gu, G.-Q. (2013) · Genesis · doi:10.1002/dvg.22384 · Cited by 112 · see citing works

Coronary Artery Development: Progenitor Cells and Differentiation Pathways

Sharma, B., Chang, A. Y., & Red‐Horse, K. (2016) · Annual Review of Physiology · doi:10.1146/annurev-physiol-022516-033953 · Cited by 109 · see citing works

Cre recombinase induces DNA damage and tetraploidy in the absence ofLoxPsites

Janbandhu, V. C., Moik, D., & Fässler, R. (2013) · Cell Cycle · doi:10.4161/cc.27271 · Cited by 106 · see citing works

Anaphylactic shock depends on endothelial Gq/G11

Korhonen, H., Fißlthaler, B., Moers, A., Wirth, A., Habermehl, D., Wieland, T., Schütz, G., Wettschureck, N., Fleming, I., & Offermanns, S. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20082150 · Cited by 106 · see citing works

Genetic lineage tracing identifies endocardial origin of liver vasculature

Zhang, H., Pu, W., Tian, X., Huang, X., He, L., Liu, Q., Li, Y., Zhang, L., He, L., Liu, K., et al. (2016) · Nature Genetics · doi:10.1038/ng.3536 · Cited by 105 · see citing works

Constitutively active Notch4 receptor elicits brain arteriovenous malformations through enlargement of capillary-like vessels

Murphy, P. A., Kim, T. N., Huang, L., Nielsen, C. M., Lawton, M. T., Adams, R. H., Schaffer, C. B., & Wang, R. A. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1415316111 · Cited by 104 · see citing works

Wnt/β-catenin signalling regulates Sox17 expression and is essential for organizer and endoderm formation in the mouse

Engert, S., Burtscher, I., Liao, W. P., Dulev, S., Schotta, G., & Lickert, H. (2013) · Development · doi:10.1242/dev.088765 · Cited by 101 · see citing works

Both primitive and definitive blood cells are derived from Flk-1+ mesoderm

Lugus, J. J., Park, C., Ma, Y. D., & Choi, K. (2008) · Blood · doi:10.1182/blood-2008-06-162750 · Cited by 96 · see citing works

System for tamoxifen‐inducible expression of cre‐recombinase from the Foxa2 locus in mice

Park, E. J., Sun, X., Nichol, P. F., Saijoh, Y., Martin, J. F., & Moon, A. (2007) · Developmental Dynamics · doi:10.1002/dvdy.21415 · Cited by 94 · see citing works

Bmx Tyrosine Kinase Has a Redundant Function Downstream of Angiopoietin and Vascular Endothelial Growth Factor Receptors in Arterial Endothelium

Rajantie, I., Ekman, N., Iljin, K., Arighi, E., Gunji, Y., Kaukonen, J., Palotie, A. V., Dewerchin, M. A., Carmeliet, P., & Alitalo, K. K. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.14.4647-4655.2001 · Cited by 89 · see citing works

Endothelial APLNR regulates tissue fatty acid uptake and is essential for apelin’s glucose-lowering effects

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APJ Regulates Parallel Alignment of Arteries and Veins in the Skin

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Endothelial VEGFR Coreceptors Neuropilin-1 and Neuropilin-2 Are Essential for Tumor Angiogenesis

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