The mTORC1 Pathway Stimulates Glutamine Metabolism and Cell Proliferation by Repressing SIRT4

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

Vander Heiden, M. G., Cantley, L. C., & Thompson, C. B. (2009) · Science · doi:10.1126/science.1160809 · Cited by 16,197

Cox’s regression model for counting processes: A large sample study

Andersen, P. K., & Gill, R. D. (1982) · The Annals of Statistics · doi:10.1214/aos/1176345976 · Cited by 4,419

The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation

DeBerardinis, R. J., Lum, J. J., Hatzivassiliou, G., & Thompson, C. B. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2007.10.002 · Cited by 4,088

mTOR: from growth signal integration to cancer, diabetes and ageing

Zoncu, R., Efeyan, A., & Sabatini, D. M. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3025 · Cited by 3,941

TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival

Inoki, K., Zhu, T., & Guan, K.-L. (2003) · Cell · doi:10.1016/s0092-8674(03)00929-2 · Cited by 3,914

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

Gwinn, D. M., Shackelford, D. B., Egan, D. F., Mihaylova, M. M., Mery, A., Vasquez, D. S., Turk, B. E., & Shaw, R. J. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.03.003 · Cited by 3,849

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

Inoki, K., Li, Y., Zhu, T., Wu, J., & Guan, K.-L. (2002) · Nature Cell Biology · doi:10.1038/ncb839 · Cited by 3,083

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

Sancak, Y., Peterson, T. R., Shaul, Y. D., Lindquist, R. A., Thoreen, C. C., Bar-Peled, L., & Sabatini, D. M. (2008) · Science · doi:10.1126/science.1157535 · Cited by 2,773

Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis

DeBerardinis, R. J., Mancuso, A., Daikhin, E., Nissim, I., Yudkoff, M., Wehrli, S., & Thompson, C. B. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709747104 · Cited by 2,622

c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

Gao, P., Tchernyshyov, I., Chang, T.-C., Lee, Y.-S., Kita, K., Ochi, T., Zeller, K. I., De Marzo, A. M., Van Eyk, J. E., Mendell, J. T., et al. (2009) · Nature · doi:10.1038/nature07823 · Cited by 2,124

Loss of heterozygosity for KrasG12D promotes REDD1-dependent, non-canonical glutamine metabolism in pancreatic ductal adenocarcinoma

Ma, Y., Li, Y., Ling, S., Li, X., Kong, B., Hu, M., & Huang, P. (2020) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2020.03.137 · Cited by 12

Pharmacologic inhibition of mTORC1 mimics dietary protein restriction in a mouse model of lactation

Pszczolkowski, V. L., Halderson, S. J., Meyer, E. J., Lin, A., & Apelo, S. I. A. (2020) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-020-00470-1 · Cited by 13

SIRT4 and SIRT6 Serve as Novel Prognostic Biomarkers With Competitive Functions in Serous Ovarian Cancer

Wang, H., Li, J., Huang, R., Fang, L., & Yu, S. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.666630 · Cited by 12

mTOR activation is critical for betulin treatment in renal cell carcinoma cells

Cheng, W., Ji, S., Zhang, H., Han, Z., Liu, Q., Wang, J., & Ping, H. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.11.153 · Cited by 12

Mammalian SIRT4 is a tumor suppressor of clear cell renal cell carcinoma by inhibiting cancer proliferation, migration and invasion

Wang, C., Piao, C., Liu, J., Zhang, Z., Zhu, Y., & Kong, C. (2020) · Cancer Biomarkers · doi:10.3233/cbm-191253 · Cited by 12

Wolbachia and Sirtuin-4 interaction is associated with alterations in host glucose metabolism and bacterial titer

Dutra, H. L. C., Deehan, M., & Frydman, H. M. (2020) · PLoS Pathogens · doi:10.1371/journal.ppat.1008996 · Cited by 12

Donepezil prevents olfactory dysfunction and α-synuclein aggregation in the olfactory bulb by enhancing autophagy in zinc sulfate-treated mice

Takahashi, K., Tsuji, M., Nakagawasai, O., Katsuyama, S., Hong, L., Miyagawa, K., Kurokawa, K., Mochida-Saito, A., Takeda, H., & Tadano, T. (2022) · Behavioural Brain Research · doi:10.1016/j.bbr.2022.114175 · Cited by 12

Sirtuins, Healthspan, and Longevity in Mammals

Giblin, W., & Lombard, D. B. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-411596-5.00003-4 · Cited by 12

How T'reg‐ulate healing of the injured spinal cord?

Milling, S. W. F., & Edgar, J. M. (2019) · Immunology · doi:10.1111/imm.13148 · Cited by 12

Mitochondrial-encoded peptide MOTS-c prevents pancreatic islet cell senescence to delay diabetes

Kong, B. S., Lee, H., L’Yi, S., Hong, S., & Cho, Y. M. (2025) · Experimental & Molecular Medicine · doi:10.1038/s12276-025-01521-1 · Cited by 13

Mitochondrial DNA competition: starving out the mutant genome

Spinazzola, A., Pérez‐Rodríguez, D., Ježek, J., & Holt, I. J. (2024) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2024.01.011 · Cited by 11

Glutaminolysis regulates endometrial fibrosis in intrauterine adhesion via modulating mitochondrial function

Chen, P., Ye, C., Huang, Y., Xu, B., Wu, T., Dong, Y., Jin, Y., Zhao, L., Hu, C., Mao, J., et al. (2024) · Biological Research · doi:10.1186/s40659-024-00492-3 · Cited by 13

Glutaminolysis is a Potential Therapeutic Target for Kidney Diseases

Ou, L., Liu, Y., Qiu, S.-T., Yang, C., Tang, J., Li, X., Liu, H., & Ye, Z.-N. (2024) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s471711 · Cited by 11

The m6A reader IGF2BP2 promotes pancreatic cancer progression through the m6A-SLC1A5-mTORC1 axis

Pu, X., Wu, Y., Long, W., Sun, X., Yuan, X., Wang, D., Wang, X., & Xu, M. (2025) · Cancer Cell International · doi:10.1186/s12935-025-03736-8 · Cited by 11

Arabidopsis thaliana sirtuins control proliferation and glutamate dehydrogenase activity

Bruscalupi, G., Micco, P. D., Failla, C. M., Pascarella, G., Morea, V., Saliola, M., Paolis, A. D., Venditti, S., & Mauro, M. L. (2022) · Plant Physiology and Biochemistry · doi:10.1016/j.plaphy.2022.11.007 · Cited by 11

Oncometabolic role of mitochondrial sirtuins in glioma patients

Haq, M. F. U., Hussain, M. Z., Mahjabeen, I., Akram, Z., Saeed, N., Shafique, R., Abbasi, S. F., & Kayani, M. A. (2023) · PLoS ONE · doi:10.1371/journal.pone.0281840 · Cited by 11

mTORC2 Puts Its Shoulder to Krebs’ Wheel

Apelo, S. I. A., & Lamming, D. W. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.08.016 · Cited by 11

mTOR has a developmental stage-specific role in mitochondrial fitness independent of conventional mTORC1 and mTORC2 and the kinase activity

Kalim, K. W., Zhang, S., Chen, X., Li, Y., Yang, J., Zheng, Y., & Guo, F. (2017) · PLoS ONE · doi:10.1371/journal.pone.0183266 · Cited by 11

SLC38A2 Overexpression Induces a Cancer‐like Metabolic Profile and Cooperates with SLC1A5 in Pan‐cancer Prognosis

Huang, M., Chang, J., Lin, W., Cheng, Y., Li, F., Suen, C., Hwang, M., Chang, C., & Mou, K. Y. (2020) · Chemistry - An Asian Journal · doi:10.1002/asia.202001056 · Cited by 11

Canceromics Studies Unravel Tumor’s Glutamine Addiction After Metabolic Reprogramming

Márquez, J., Matés, J. M., Alonso, F. J., Martín‐Rufián, M., Lobo, C., & Campos-Sandoval, J. A. (2015) · Springer eBooks · doi:10.1007/978-3-7091-1824-5_12 · Cited by 11

A Mitochondrial Perspective on Noncommunicable Diseases

Zheng, Y., Zhang, J., Zhu, X., Wei, Y., Zhao, W., Si, S., & Li, Y. (2023) · Biomedicines · doi:10.3390/biomedicines11030647 · Cited by 11

Brisk walking improves motor function and lower limb muscle strength in Chinese women aged 80 years and older

Wang, Y., Lu, Y., Fang, Z., Yan, H., Li, J., Ye, Z., Yu, Y., & Shan, W. (2024) · Scientific Reports · doi:10.1038/s41598-024-55925-6 · Cited by 13

Multi-omics reveals the molecular mechanism of the combined toxic effects of PFOA and 4-HBP exposure in MCF-7 cells and the key player: mTORC1

Yang, S.-L., Ma, B., Lu, Y.-S., Chen, J., Jiang, Y., Qiu, J. Y., Qian, Y., & Xu, Y. (2024) · Environment International · doi:10.1016/j.envint.2024.108778 · Cited by 10

A metabolomics comparison in milk from two Dezhou donkey strains

Li, Y., Ma, Q., Zhou, M.-M., Zhang, Z., Zhan, Y., Liu, G., Zhu, M.-X., & Wang, C. (2022) · European Food Research and Technology · doi:10.1007/s00217-022-03962-8 · Cited by 10

T-cell Metabolism as a Target to Control Autoreactive T Cells in β-Cell Autoimmunity

Bordignon, C., Canu, A., Dyczko, A., Leone, S., & Monti, P. (2017) · Current Diabetes Reports · doi:10.1007/s11892-017-0848-5 · Cited by 10

Effectiveness and mechanism study of glutamine on alleviating hypermetabolism in burned rats

Yang, Y., Liu, M., Zhang, Y., Wang, Z. E., DanWu, Fan, S., Yan, W., Xia, L., & Peng, X. (2020) · Nutrition · doi:10.1016/j.nut.2020.110934 · Cited by 10

[18F]Fluorocholine and [18F]Fluoroacetate PET as Imaging Biomarkers to Assess Phosphatidylcholine and Mitochondrial Metabolism in Preclinical Models of TSC and LAM

Verwer, E. E., Kavanagh, T. R., Mischler, W. J., Feng, Y., Takahashi, K., Wang, S., Shoup, T. M., Neelamegam, R., Yang, J., Guehl, N. J., et al. (2018) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-17-3693 · Cited by 10

Rotavirus rewires host cell metabolic pathways toward glutamine catabolism for effective virus infection

Mitra, S., Chaudhuri, R. D., Sarkar, R., Banerjee, S., Mukherjee, A., Sharma, R. P., Gope, A., Kitahara, K., Miyoshi, S.-I., & Chawla‐Sarkar, M. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2428425 · Cited by 9

Sirtuin 4 Inhibits Prostate Cancer Progression and Metastasis by Modulating p21 Nuclear Translocation and Glutamate Dehydrogenase 1 ADP-Ribosylation

Mao, L., Hong, X., Xu, L., Wang, X., Liu, J., Wang, H., Qian, Y., Zhao, J., & Jia, R. (2022) · Journal of Oncology · doi:10.1155/2022/5498743 · Cited by 9

Epigenetic silencing of ZIC4 unveils a potential tumor suppressor role in pediatric choroid plexus carcinoma

Hesham, D., Mosaab, A., Amer, N., Al‐Shehaby, N., Magdeldin, S., Hassan, A., Georgiev, H., Elshoky, H. A., Rady, M., Abou‐Aisha, K., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-71188-7 · Cited by 9

Glutamine substitution: the role it can play to enhance therapeutic protein production

Ha, T. K., & Lee, G. M. (2015) · Pharmaceutical Bioprocessing · doi:10.4155/pbp.15.6 · Cited by 9

Sirtuins in Brain and Neurodegenerative Disease

Szegő, É. M., Outeiro, T. F., & Kazantsev, A. G. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-813499-3.00013-7 · Cited by 9

Anti-Tumor Effects of Bak-Proteoliposomes against Glioblastoma

Liguori, L., Pastorino, F., Rousset, X., Alfano, S., Cortès, S., Emionite, L., Daga, A., Ponzoni, M., & Lenormand, J. (2015) · Molecules · doi:10.3390/molecules200915893 · Cited by 9

Metabolic Evaluation of MYCN-Amplified Neuroblastoma by 4-[18F]FGln PET Imaging

Li, C., Huang, S., Guo, J., Wang, C., Huang, Z., Huang, R., Liu, L., Liang, S., & Wang, H. (2019) · Molecular Imaging and Biology · doi:10.1007/s11307-019-01330-9 · Cited by 9

A ternary complex model of Sirtuin4-NAD+-Glutamate dehydrogenase

Kato, Y. S., Kihara, H., Fukui, K., & Kojima, M. (2018) · Computational Biology and Chemistry · doi:10.1016/j.compbiolchem.2018.03.006 · Cited by 9

Nuclear translocation of SIRT4 mediates deacetylation of U2AF2 to modulate renal fibrosis through alternative splicing-mediated upregulation of CCN2Preprint

Yang, G., Xiang, J., Yang, X., Liu, X., Li, Y., Li, L., Kang, L., Liang, Z., & Yang, S. (2024) · eLife · doi:10.7554/elife.98524 · Cited by 9

DIMINISHED EXPRESSION OF GLS IN CD4+ T CELLS SERVES AS A PROGNOSTIC INDICATOR ASSOCIATED WITH CUPROPTOSIS IN SEPTIC PATIENTS

Yang, J., Chen, N., Zhao, P., Yang, X., Li, Y., Fu, Z., Yang, Y., Dong, N., Li, S., Yao, R.-Q., et al. (2024) · Shock · doi:10.1097/shk.0000000000002370 · Cited by 9

The Research Progress of Metformin Regulation of Metabolic Reprogramming in Malignant Tumors

Sui, Q., Yang, H., Hu, Z., Jin, X., Chen, Z., Jiang, W., & Sun, F. (2024) · Pharmaceutical Research · doi:10.1007/s11095-024-03783-2 · Cited by 8

Energy-replenishing, mitochondria-targeted hydrogel microspheres mitigate sarcopenia via cellular senescence amelioration

Bao, W., Liu, S., Du, C., Liu, J., Luo, X., he, Y., Huang, D., Xu, W., Lei, Y., Huang, W., et al. (2026) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.114595 · Cited by 9

Differential metabolic sensitivity of insulin-like-response- and TORC1-dependent overgrowth inDrosophilafat cells

Devilliers, M., Garrido, D., Poidevin, M., Rubin, T., Rouzic, A. L., & Montagne, J. (2020) · Genetics · doi:10.1093/genetics/iyaa010 · Cited by 9

Unravelling the Interplay between Cardiac Metabolism and Heart Regeneration

Yu, F., Cong, S., Yap, E. P., Hausenloy, D. J., & Ramachandra, C. J. A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241210300 · Cited by 8

A new view on functions of the lysine demalonylase activity of SIRT5

Nahálková, J. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.121572 · Cited by 8

Epigenetic roles of lysine-specific demethylase 1 (LSD1) in cancer metabolism

Cheng, B., Xu, X., Fan, B., Ma, T., & Yu, B. (2025) · Drug Discovery Today · doi:10.1016/j.drudis.2025.104397 · Cited by 7

Harmonic activity of glutamate dehydrogenase and neuroplasticity: The impact on aging, cognitive dysfunction, and neurodegeneration

Salarvandian, S., Digaleh, H., Khodagholi, F., Javadpour, P., Asadi, S., Zaman, A. A. O., & Dargahi, L. (2024) · Behavioural Brain Research · doi:10.1016/j.bbr.2024.115399 · Cited by 7

Bone-Induced HER2 Promotes Secondary Metastasis in HR+/HER2− Breast Cancer

Alam, R., Reva, A., Edwards, D. G., Lege, B. M., Munoz-Arcos, L. S., Reduzzi, C., Singh, S., Hao, X., Wu, Y.-H., Tian, Z., et al. (2025) · Cancer Discovery · doi:10.1158/2159-8290.cd-23-0543 · Cited by 10

Gene expression and prognosis of sirtuin family members in ovarian cancer

Zeng, Z., Huang, Y., Li, Y., Huang, S., Wang, J., Tang, Y., & Jiang, Y. (2020) · Medicine · doi:10.1097/md.0000000000020685 · Cited by 7

The Neglected Liaison: Targeting Cancer Cell Metabolic Reprogramming Modifies the Composition of Non-Malignant Populations of the Tumor Microenvironment

Iorio, M. C., Ganesh, N. U., Luise, M. D., Porcelli, A. M., Gasparre, G., & Kurelac, I. (2021) · Cancers · doi:10.3390/cancers13215447 · Cited by 7

Sirtuin 5 alleviates apoptosis and autophagy stimulated by ammonium chloride in bovine mammary epithelial cells

He, J., Feng, L., Yang, H., Gao, S., Dong, J., Lu, G., Liu, L., Zhang, X., Zhong, K., Guo, S., et al. (2024) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2024.12584 · Cited by 6

Down‐regulation of mitogen‐activated protein kinases and nuclear factor‐ κB signaling is involved in rapamycin suppression of TLR2‐induced inflammatory response in monocytic THP‐1 cells

Sun, R., Zhang, Y., Ma, S., Qi, H.-T., Wang, M., Duan, J.-H., Ma, S., Zhu, X., Li, G., & Wang, H. (2015) · Microbiology and Immunology · doi:10.1111/1348-0421.12321 · Cited by 7

Molecular and functional characterization of sirt4 and sirt6 in Megalobrama amblycephala under high glucose metabolism

Lin, S., Teng, L.-Z., Lin, Y., Miao, L., Ge, X., Hao, J.-Y., Huang, X., & Liu, B. (2019) · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · doi:10.1016/j.cbpb.2019.01.010 · Cited by 7

Advances of SIRT4 in cancer metabolism and therapy

Yue, X., Shi, Y., & Luo, Q. (2023) · Pediatric Discovery · doi:10.1002/pdi3.17 · Cited by 6

Phosphorylation of mTOR Ser2481 is a key target limiting the efficacy of rapalogs for treating hepatocellular carcinoma

Watari, K., Nishitani, A., Shibata, T., Noda, M., Kawahara, A., Akiba, J., Murakami, Y., Yano, H., Kuwano, M., & Ono, M. (2016) · Oncotarget · doi:10.18632/oncotarget.10161 · Cited by 6

Effect of long term palmitate treatment on osteogenic differentiation of human mesenchymal stromal cells - Impact of albumin

Glenske, K., Schaepe, K., Wieck, A., Failing, K., Werner, J., Rohnke, M., Wenisch, S., & Mazurek, S. (2020) · Bone Reports · doi:10.1016/j.bonr.2020.100707 · Cited by 6

Farnesysltransferase Inhibitor Prevents Burn Injury-Induced Metabolome Changes in Muscle

Nakazawa, H., Wong, L. P., Shelton, L. M., Sadreyev, R. I., & Kaneki, M. (2022) · Metabolites · doi:10.3390/metabo12090800 · Cited by 6

Targeted metabolomics detects a putatively diagnostic signature in plasma and dried blood spots from head and neck paraganglioma patients

Fabritiis, S. D., Valentinuzzi, S., Piras, G., Cicalini, I., Pieragostino, D., Pagotto, S., Perconti, S., Zucchelli, M., Schena, A., Taschin, E., et al. (2023) · Oncogenesis · doi:10.1038/s41389-023-00456-4 · Cited by 6

Two is company, is three a crowd? Triplet therapy, novel molecular targets, and updates on the management of advanced renal cell carcinoma

Goodstein, T. A., Yang, Y., Runcie, K. D., Srinivasan, R., & Singer, E. A. (2023) · Current Opinion in Oncology · doi:10.1097/cco.0000000000000939 · Cited by 6

Lipid Metabolism in Relation to Carbohydrate Metabolism

Akiki, P., Delamotte, P., & Montagne, J. (2024) · Advances in experimental medicine and biology · doi:10.1007/5584_2024_821 · Cited by 7

mTORC1 Controls Synthesis of Its Activator GTP

Benjamin, D., & Hall, M. N. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.06.032 · Cited by 6

Thyroid cancer cell metabolism: A glance into cell culture system-based metabolomics approaches

Abooshahab, R., Razavi, F., Ghorbani, F., Hooshmand, K., Zarkesh, M., & Hedayati, M. (2024) · Experimental Cell Research · doi:10.1016/j.yexcr.2024.113936 · Cited by 5

Nuclear translocation of SIRT4 mediates deacetylation of U2AF2 to modulate renal fibrosis through alternative splicing-mediated upregulation of CCN2

Yang, G., Xiang, J., Yang, X., Liu, X., Li, Y.-C., Li, L., Kang, L., Liang, Z., & Yang, S. (2024) · eLife · doi:10.7554/elife.98524.3 · Cited by 5

The curious case of mitochondrial sirtuin in rewiring breast cancer metabolism: Mr Hyde or Dr Jekyll?

Tharayil, J. S., Kandettu, A., & Chakrabarty, S. (2025) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2025.167691 · Cited by 5

The Role of the Sirtuin Family Histone Deacetylases in Acute Myeloid Leukemia—A Promising Road Ahead

Strzałka, P., Krawiec, K. M., Wiśnik, A., Jarych, D., Czemerska, M., Zawlik, I., Pluta, A., & Wierzbowska, A. (2025) · Cancers · doi:10.3390/cancers17061009 · Cited by 5

Sirtuin Modulation as Novel Neuroprotective Strategy for Alzheimer’s Disease

Polito, L., Biella, G., & Albani, D. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-803690-7.00008-9 · Cited by 5

Role of sirtuins in esophageal cancer: Current status and future prospects

Otsuka, R., Hayano, K., & Matsubara, H. (2022) · World Journal of Gastrointestinal Oncology · doi:10.4251/wjgo.v14.i4.794 · Cited by 7

Glutamate Metabolism Regulates Immune Escape of Glioma

Cai, Y., Guo, T., Wang, Y., & Du, J. (2018) · Madridge Journal of Immunology · doi:10.18689/mjim-1000113 · Cited by 5

Targeting glutaminase and mTOR

Tanaka, K., Sasayama, T., & Kohmura, E. (2015) · Oncotarget · doi:10.18632/oncotarget.5263 · Cited by 5

Cellular metabolism biosensing: From extracellular microenvironment to intracellular physiology monitoring

Liang, T., Gu, C., Fang, J., Xu, D., Wang, Z., Chiappini, C., & Hu, N. (2025) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2025.118250 · Cited by 4

Orchestration of Mitochondrial Function and Remodeling by Post-Translational Modifications Provide Insight into Mechanisms of Viral Infection

Park, J. W., Tyl, M. D., & Cristea, I. M. (2023) · Biomolecules · doi:10.3390/biom13050869 · Cited by 4

Glutamine ameliorates Bungarus multicinctus venom-induced lung and heart injury through HSP70: NF-κB p65 and P53/PUMA signaling pathways involved

Li, Y., Guan, Z., Hu, S., Huang, Z., He, D., Cheng, X., Song, T., Mo, C., Xiao, M., Huang, Y. M., et al. (2023) · The Journal of venomous animals and toxins including tropical diseases · doi:10.1590/1678-9199-jvatitd-2022-0080 · Cited by 4

Hormone-Independent Mouse Mammary Adenocarcinomas with Different Metastatic Potential Exhibit Different Metabolic Signatures

Bispo, D. S. C., Fabris, V. T., Lamb, C. A., Lanari, C., Helguero, L. A., & Gil, A. M. (2020) · Biomolecules · doi:10.3390/biom10091242 · Cited by 4

Moving towards a novel therapeutic strategy for hyperammonemia that targets glutamine metabolism

Fukui, K., Takahashi, T., Matsunari, H., Uchikura, A., Watanabe, M., Nagashima, H., Ishihara, N., Kakuma, T., Watanabe, Y., Yamashita, Y., et al. (2022) · Journal of Inherited Metabolic Disease · doi:10.1002/jimd.12540 · Cited by 4

Adaptive Benefits of Storage Strategy and Dual AMPK/TOR Signaling in Metabolic Stress Response

Pfeuty, B., & Thommen, Q. (2016) · PLoS ONE · doi:10.1371/journal.pone.0160247 · Cited by 4

Cancer Biology and the Principles of Targeted Cancer Drug Discovery

Hillmann, P., Schmitz, D., Mestan, J., D'Allonzo, S., & Fabbro, D. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-409547-2.12390-x · Cited by 4

Inhibition of the mTORC1/NF‐κB Axis Alters Amino Acid Metabolism in Human Hepatocytes

Zhang, M., Fu, Y., Chen, Y., Ma, Y., Guo, Z., Wang, Y., Hao, H., Fu, Q., & Wang, Z. (2021) · BioMed Research International · doi:10.1155/2021/8621464 · Cited by 4

Therapeutic strategies for treatment of pulmonary lymphangioleiomyomatosis

Krymskaya, V. P. (2014) · Expert Opinion on Orphan Drugs · doi:10.1517/21678707.2014.953481 · Cited by 4

Mitochondrial Sirtuins

Yang, W., van de Ven, R. A. H., & Haigis, M. C. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-813499-3.00008-3 · Cited by 4

Deregulation of Mitochondrial Sirtuins and OGG1-2a Acts as a Prognostic and Diagnostic Biomarker in Leukemia

Zoraiz, K., Attique, M., Shahbaz, S., Ahmed, M. W., Kayani, M. A., & Mahjabeen, I. (2021) · Future Oncology · doi:10.2217/fon-2020-1155 · Cited by 4

Glucose and glutamine metabolism-related protein expression in breast ductal carcinoma in situ

Ryu, H. J., & Koo, J. S. (2022) · Neoplasma · doi:10.4149/neo_2022_220103n3 · Cited by 4

Tripartite Motif-Containing 2, a Glutamine Metabolism-Associated Protein, Predicts Poor Patient Outcome in Triple-Negative Breast Cancer Treated with Chemotherapy

Masisi, B. K., Ansari, R. E., Alfarsi, L. H., Fakroun, A., Erkan, B., Ibrahim, A., Toss, M. S., Ellis, I. O., Rakha, E. A., & Green, A. R. (2024) · Cancers · doi:10.3390/cancers16111949 · Cited by 3

The mTOR Complexes in Cancer Cell Metabolism

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Sirtuins and cellular metabolism in cancers

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Effects of Phosphatidic Acid on Mammalian Target of Rapamycin (mTOR) and Metabolic Pathways in Bivalve Mollusk Sinonovacula constricta

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Involvement of mTOR signaling in physiopathology and its potential therapeutic interventions

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Genetic Interactions of Mitochondrial Sirtuins in Brain Tumorigenesis

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Peptide Microarrays for Profiling of Epigenetic Targets

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Cancer RNome: Evolution and Sustenance

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Therapeutic Targeting of Glutamine Metabolism in Colorectal Cancer

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Sirtuins, healthspan, and longevity in mammals

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A Tale of Three Proteomes: Visualizing Protein and Transcript Abundance Relationships in the Breast Cancer Proteome Portal

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CoCl 2 ‐triggered pseudohypoxic stress induces proteasomal degradation of SIRT4 via polyubiquitination of lysines K78 and K299

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Differential Metabolic Sensitivity of Insulin-like-response- and mTORC1-Dependent Overgrowth in Drosophila Fat CellsPreprint

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Identification of novel miRNA targets in CHO cell lines and characterization of their impact on protein N-glycosylationPreprint

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Deleterious coding variation associated with autism is consistent across populations, as exemplified by admixed Latin American populationsPreprint

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Dipeptide alanine-glutamine ameliorates retinal neurodegeneration in an STZ-induced rat model

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Oxidative stress and cancer metabolism: From pathogenesis to therapeutic opportunities

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PTSD and appetite dysregulation: mTOR-dependent modulation of fear memory and satiety circuits

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The role of the resveratrol-sirtuin axis in the treatment of metabolic dysfunction-associated diseases

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Decreased sirtuin 4 levels promote cellular proliferation and invasion in papillary thyroid carcinoma

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Sirtuins and Aging

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When Cancer Cells Are Given Lemo[NH3]s, They Make Lemo[NH3]ade

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mTORC1 Stimulates Glutamine Metabolism

Foley, J. F. (2013) · Science Signaling · doi:10.1126/scisignal.2004338

Mechanistic target of rapamycin complex (mTORC)-glutamine axis in cancer: Mechanistic crosstalk, therapeutic resistance, and clinical opportunities

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mTORC1 Regulates Glutamine Metabolism

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Abstract 21: The mTORC2 target Akt is regulated in response to glutamine metabolite levels

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Biochemical characterization of mTORC1 regulation by glutamine metabolism

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