The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.
Jpx RNA Activates Xist by Evicting CTCF
Open accessAbstract
Summary In mammals, dosage compensation between XX and XY individuals occurs through X chromosome inactivation (XCI). The noncoding Xist RNA is expressed and initiates XCI only when more than one X chromosome is present. Current models invoke a dependency on the X-to-autosome ratio (X:A), but molecular factors remain poorly defined. Here, we demonstrate that molecular titration between an X-encoded RNA and an autosomally encoded protein dictates Xist induction. In pre-XCI cells, CTCF protein represses Xist transcription. At the onset of XCI, Jpx RNA is upregulated, binds CTCF, and extricates CTCF from one Xist allele. We demonstrate that CTCF is an RNA-binding protein and is titrated away from the Xist promoter by Jpx RNA. Thus, Jpx activates Xist by evicting CTCF. The functional antagonism via molecular titration reveals a role for long noncoding RNA in epigenetic regulation.
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Metadata
- Authors
- Sun, S., Del Rosario, B. C., Szanto, A., Ogawa, Y., Jeon, Y., & Lee, J. T.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2013-06
- Volume
- 153
- Issue
- 7
- Pages
- 1537-1551
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2149710757
- Cited by
- 323
- References
- 54
- FWCI
- 22.25
- Type
- journal article
- Language
- en
- Open access
- bronze
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