The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Human SNP Links Differential Outcomes in Inflammatory and Infectious Disease to a FOXO3-Regulated Pathway
Open accessAbstract
The clinical course and eventual outcome, or prognosis, of complex diseases varies enormously between affected individuals. This variability critically determines the impact a disease has on a patient's life but is very poorly understood. Here, we exploit existing genome-wide association study data to gain insight into the role of genetics in prognosis. We identify a noncoding polymorphism in FOXO3A (rs12212067: T > G) at which the minor (G) allele, despite not being associated with disease susceptibility, is associated with a milder course of Crohn's disease and rheumatoid arthritis and with increased risk of severe malaria. Minor allele carriage is shown to limit inflammatory responses in monocytes via a FOXO3-driven pathway, which through TGFβ1 reduces production of proinflammatory cytokines, including TNFα, and increases production of anti-inflammatory cytokines, including IL-10. Thus, we uncover a shared genetic contribution to prognosis in distinct diseases that operates via a FOXO3-driven pathway modulating inflammatory responses.
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Cites
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
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The Colonic Crypt Protects Stem Cells from Microbiota-Derived Metabolites
Kaiko, G. E., Ryu, S. H., Koues, O. I., Collins, P. L., Solnica-Krezel, L., Pearce, E. J., Pearce, E. L., Oltz, E. M., & Stappenbeck, T. S. (2016) · Cell · doi:10.1016/j.cell.2016.05.018 · Cited by 733
FOXO3: A Major Gene for Human Longevity - A Mini-Review
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Lee, J. C., Biasci, D., Roberts, R., Gearry, R. B., Mansfield, J. C., Ahmad, T., Prescott, N. J., Satsangi, J., Wilson, D. C., Jostins, L., et al. (2017) · Nature Genetics · doi:10.1038/ng.3755 · Cited by 304
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T-cell exhaustion: understanding the interface of chronic viral and autoinflammatory diseases
McKinney, E. F., & Smith, K. G. (2016) · Immunology & Cell Biology · doi:10.1038/icb.2016.81 · Cited by 36
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Metadata
- Authors
- Lee, J. C., Espéli, M., Anderson, C. A., Linterman, M. A., Pocock, J. M., Williams, N. J., Roberts, R., Viatte, S., Fu, B., Peshu, N., Hien, T. T., Phu, N. H., Wesley, E., Edwards, C., Ahmad, T., Mansfield, J. C., Gearry, R., Dunstan, S., Williams, T. N., Barton, A., Vinuesa, C. G., Phillips, A., Mowat, C., Drummond, H., Kennedy, N., Lees, C. W., Satsangi, J., Taylor, K., Prescott, N. J., Mathew, C. G., Simpson, P., Simmons, A., Khan, M., Newman, W. G., Hawkey, C., Hart, A., Wilson, D. C., Henderson, P., Barrett, J. C., Parkes, M., Lyons, P. A., & Smith, K. G. C.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2013-09
- Volume
- 155
- Issue
- 1
- Pages
- 57-69
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2110027059
- Cited by
- 231
- References
- 10
- FWCI
- 12.51
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Lee, J. C., Espéli, M., Anderson, C. A., Linterman, M. A., Pocock, J. M., Williams, N. J., Roberts, R., Viatte, S., Fu, B., Peshu, N., Hien, T. T., Phu, N. H., Wesley, E., Edwards, C., Ahmad, T., Mansfield, J. C., Gearry, R., Dunstan, S., Williams, T. N., . . . Smith, K. G. C. (2013). Human SNP Links Differential Outcomes in Inflammatory and Infectious Disease to a FOXO3-Regulated Pathway. Cell. https://doi.org/10.1016/j.cell.2013.08.034
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
