The FoxO transcription factors and metabolic regulation

The pathogenesis of atherosclerosis: a perspective for the 1990s

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Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor

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The phosphoinositide 3-kinase pathway

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The Wnt Signaling Pathway in Development and Disease

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Wnt signalling in stem cells and cancer

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Molecular Regulation of Vascular Smooth Muscle Cell Differentiation in Development and Disease

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Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase

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Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1

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Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy.

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Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)

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Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo

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Obesity and the regulation of energy balance

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Role of Brain Insulin Receptor in Control of Body Weight and Reproduction

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The IGF-1/PI3K/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factors.

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Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ

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The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans

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Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans

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Inhibition of Adipogenesis by Wnt Signaling

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Disruption of IRS-2 causes type 2 diabetes in mice

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Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1

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FoxOs Are Critical Mediators of Hematopoietic Stem Cell Resistance to Physiologic Oxidative Stress

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SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27

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Insulin-regulated hepatic gluconeogenesis through FOXO1–PGC-1α interaction

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CREB regulates hepatic gluconeogenesis through the coactivator PGC-1

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SKP1 Connects Cell Cycle Regulators to the Ubiquitin Proteolysis Machinery through a Novel Motif, the F-Box

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Untitled work

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Mammalian SIRT1 Represses Forkhead Transcription Factors

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FOXO transcription factors at the interface between longevity and tumor suppression

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Co-crystal structure of the HNF-3/fork head DNA-recognition motif resembles histone H5

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Unified nomenclature for the winged helix/forkhead transcription factorsPreprint

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Tissue-Specific Knockout of the Insulin Receptor in Pancreatic β Cells Creates an Insulin Secretory Defect Similar to that in Type 2 Diabetes

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Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1

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FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis

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Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling

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Suppression of Ovarian Follicle Activation in Mice by the Transcription Factor Foxo3a

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Adipose Tissue Selective Insulin Receptor Knockout Protects against Obesity and Obesity-Related Glucose Intolerance

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FOXO transcription factor activation by oxidative stress mediated by the small GTPase Ral and JNK

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Phosphorylation of the Transcription Factor Forkhead Family Member FKHR by Protein Kinase B*

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Negative Regulation of the Forkhead Transcription Factor FKHR by Akt

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Functional Interaction Between ß-Catenin and FOXO in Oxidative Stress Signaling

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The Forkhead Transcription Factor Foxo1 Regulates Adipocyte Differentiation

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Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats

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A phylogenetically conserved NAD ⁺ -dependent protein deacetylase activity in the Sir2 protein family

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Sirt1 Regulates Insulin Secretion by Repressing UCP2 in Pancreatic β Cells

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Signalling pathways that mediate skeletal muscle hypertrophy and atrophy

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Disruption of forkhead transcription factor (FOXO) family members in mice reveals their functional diversification

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The forkhead transcription factor Foxo1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression

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The forkhead transcription factor Foxo1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression

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Myogenic Vector Expression of Insulin-like Growth Factor I Stimulates Muscle Cell Differentiation and Myofiber Hypertrophy in Transgenic Mice

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Increased dosage of mammalian Sir2 in pancreatic β cells enhances glucose-stimulated insulin secretion in mice

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Impaired Regulation of Hepatic Glucose Production in Mice Lacking the Forkhead Transcription Factor Foxo1 in Liver

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Regulation of insulin action and pancreatic β-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1

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Control of cell number by Drosophila FOXO: downstream and feedback regulation of the insulin receptor pathwayPreprint

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Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity

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Serum response factor: toggling between disparate programs of gene expression

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The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic β cell growth

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Skeletal Muscle FOXO1 (FKHR) Transgenic Mice Have Less Skeletal Muscle Mass, Down-regulated Type I (Slow Twitch/Red Muscle) Fiber Genes, and Impaired Glycemic Control

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Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats

Obici, S., Feng, Z., Karkanias, G. B., et al. (2002) · Nature Neuroscience · doi:10.1038/nn861 · Cited by 572 · see citing works

14-3-3 transits to the nucleus and participates in dynamic nucleocytoplasmic transport

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Nuclear Trapping of the Forkhead Transcription Factor FoxO1 via Sirt-dependent Deacetylation Promotes Expression of Glucogenetic Genes*

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FoxO1 protects against pancreatic β cell failure through NeuroD and MafA induction

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Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia.

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Regulation of gene expression by insulin

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FOXO4 Is Acetylated upon Peroxide Stress and Deacetylated by the Longevity Protein hSir2

van der Horst, A., Tertoolen, L. G. J., Smits, L. M. M., Frye, R. A., Medema, R. H., & Burgering, B. M. T. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m401138200 · Cited by 541 · see citing works

JNK Extends Life Span and Limits Growth by Antagonizing Cellular and Organism-Wide Responses to Insulin Signaling

Wang, M. C., Bohmann, D., & Jasper, H. (2005) · Cell · doi:10.1016/j.cell.2005.02.030 · Cited by 537 · see citing works

Insulin-induced phosphorylation of FKHR (Foxo1) targets to proteasomal degradation

Matsuzaki, H., Daitoku, H., Hatta, M., Tanaka, K., & Fukamizu, A. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1934283100 · Cited by 534 · see citing works

JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16

Oh, S. W., Mukhopadhyay, A., Svrzikapa, N., Jiang, F., Davis, R. J., & Tissenbaum, H. A. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500749102 · Cited by 531 · see citing works

Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation

Huang, H., Regan, K. M., Wang, F., Wang, D., Smith, D. I., van Deursen, J. M. A., & Tindall, D. J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0406789102 · Cited by 519 · see citing works

Interacting genes in nematode dauer larva formation

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FoxO1 Regulates Multiple Metabolic Pathways in the Liver

Zhang, W., Patil, S., Chauhan, B., Guo, S., Powell, D. R., Le, J., Klotsas, A., Matika, R. W., Xiao, X., Franks, R. R., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m600272200 · Cited by 517 · see citing works

Acetylation of Foxo1 alters its DNA-binding ability and sensitivity to phosphorylation

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The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic β cell growth

Kitamura, T., Nakae, J., Kitamura, Y., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci200216857 · Cited by 479 · see citing works

Insulin Stimulates Phosphorylation of the Forkhead Transcription Factor FKHR on Serine 253 through a Wortmannin-sensitive Pathway

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How does calorie restriction work?Preprint

Koubova, J., & Guarente, L. (2003) · Genes & Development · doi:10.1101/gad.1052903 · Cited by 457 · see citing works

IRS-2 pathways integrate female reproduction and energy homeostasis

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Forkhead protein FoxO1 mediates Agrp-dependent effects of leptin on food intake

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Dual role of transcription factor FoxO1 in controlling hepatic insulin sensitivity and lipid metabolism

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PI3K integrates the action of insulin and leptin on hypothalamic neurons

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Non-ageing developmental variant of Caenorhabditis elegans

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β-cell–specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter β-cell mass

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The role of endothelial insulin signaling in the regulation of vascular tone and insulin resistance

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FoxO6, a Novel Member of the FoxO Class of Transcription Factors with Distinct Shuttling Dynamics

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Abnormal Angiogenesis in Foxo1 (Fkhr)-deficient Mice

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The NOD2 p.Leu1007fsX1008 Mutation (rs2066847) Is a Stronger Predictor of the Clinical Course of Crohn's Disease than the FOXO3A Intron Variant rs12212067

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AMPK: A promising molecular target for combating cisplatin toxicities

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