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Cited by 200

The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.

KSR2 Mutations Are Associated with Obesity, Insulin Resistance, and Impaired Cellular Fuel Oxidation

Open access
Pearce, Laura R., Atanassova, Neli, Banton, Matthew C., Bottomley, Bill, van der Klaauw, Agatha A., Revelli, Jean-Pierre, Hendricks, Audrey, Keogh, Julia M., Henning, Elana, Doree, Deon, Jeter-Jones, Sabrina, Garg, Sumedha, Bochukova, Elena G., Bounds, Rebecca, Ashford, Sofie, Gayton, Emma, Hindmarsh, Peter C., Shield, Julian P.H., Crowne, Elizabeth, Barford, David, Wareham, Nick J., O’Rahilly, Stephen, Murphy, Michael P., Powell, David R., Barroso, Ines, Farooqi, I. Sadaf·2013·Cell
DOI 10.1016/j.cell.2013.09.058
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Abstract

Kinase suppressor of Ras 2 (KSR2) is an intracellular scaffolding protein involved in multiple signaling pathways. Targeted deletion of Ksr2 leads to obesity in mice, suggesting a role in energy homeostasis. We explored the role of KSR2 in humans by sequencing 2,101 individuals with severe early-onset obesity and 1,536 controls. We identified multiple rare variants in KSR2 that disrupt signaling through the Raf-MEKERK pathway and impair cellular fatty acid oxidation and glucose oxidation in transfected cells; effects that can be ameliorated by the commonly prescribed antidiabetic drug, metformin. Mutation carriers exhibit hyperphagia in childhood, low heart rate, reduced basal metabolic rate and severe insulin resistance. These data establish KSR2 as an important regulator of energy intake, energy expenditure, and substrate utilization in humans. Modulation of KSR2-mediated effects may represent a novel therapeutic strategy for obesity and type 2 diabetes.

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Metadata

Authors
Pearce, L. R., Atanassova, N., Banton, M. C., Bottomley, B., van der Klaauw, A. A., Revelli, J.-P., Hendricks, A., Keogh, J. M., Henning, E., Doree, D., Jeter-Jones, S., Garg, S., Bochukova, E. G., Bounds, R., Ashford, S., Gayton, E., Hindmarsh, P. C., Shield, J. P. H., Crowne, E., Barford, D., Wareham, N. J., O’Rahilly, S., Murphy, M. P., Powell, D. R., Barroso, I., & Farooqi, I. S.
Venue
Cell
Publisher
Elsevier BV
Published
2013-11
Volume
155
Issue
4
Pages
765-777
ISSN
0092-8674 (ISSN-L)
DOI
10.1016/j.cell.2013.09.058
OpenAlex
W2155416684
Cited by
200
References
8
FWCI
9.41
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: KSR2 Mutations Are Associated with Obesity, Insulin Resistance, and Impaired Cellular Fuel Oxidation. https://app.cochat.ai/papers/10.1016/j.cell.2013.09.058
The paper
Pearce, L. R., Atanassova, N., Banton, M. C., Bottomley, B., van der Klaauw, A. A., Revelli, J.-P., Hendricks, A., Keogh, J. M., Henning, E., Doree, D., Jeter-Jones, S., Garg, S., Bochukova, E. G., Bounds, R., Ashford, S., Gayton, E., Hindmarsh, P. C., Shield, J. P. H., Crowne, E., . . . Farooqi, I. S. (2013). KSR2 Mutations Are Associated with Obesity, Insulin Resistance, and Impaired Cellular Fuel Oxidation. Cell. https://doi.org/10.1016/j.cell.2013.09.058

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.