LKB1 and AMP-activated protein kinase control of mTOR signalling and growth

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AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism

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Ras, PI(3)K and mTOR signalling controls tumour cell growth

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The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin

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The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

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A serine/threonine kinase gene defective in Peutz–Jeghers syndrome

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AMP-activated protein kinase induces a p53-dependent metabolic checkpoint

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A central integrator of transcription networks in plant stress and energy signalling

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mTOR controls mitochondrial oxidative function through a YY1–PGC-1α transcriptional complex

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SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth

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LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR‐1

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TSC2 Integrates Wnt and Energy Signals via a Coordinated Phosphorylation by AMPK and GSK3 to Regulate Cell Growth

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p53 Target Genes Sestrin1 and Sestrin2 Connect Genotoxic Stress and mTOR Signaling

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Tor, a Phosphatidylinositol Kinase Homologue, Controls Autophagy in Yeast

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Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway

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Hypothalamic mTOR Signaling Regulates Food Intake

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mTOR and S6K1 Mediate Assembly of the Translation Preinitiation Complex through Dynamic Protein Interchange and Ordered Phosphorylation Events

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Sirolimus for Angiomyolipoma in Tuberous Sclerosis Complex or Lymphangioleiomyomatosis

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AMP-Activated Protein Kinase in Metabolic Control and Insulin Signaling

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PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase

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AMPK and PPARδ Agonists Are Exercise Mimetics

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Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress

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Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40

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The TSC1-2 tumor suppressor controls insulin–PI3K signaling via regulation of IRS proteins

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The LKB1 tumor suppressor negatively regulates mTOR signaling

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LKB1 modulates lung cancer differentiation and metastasis

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Influence of TOR kinase on lifespan in C. elegans

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The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism

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mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways

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Increased Cancer-Related Mortality for Patients With Type 2 Diabetes Who Use Sulfonylureas or Insulin

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Does the ribosome translate cancer?

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A Role for AMP-Activated Protein Kinase in Contraction- and Hypoxia-Regulated Glucose Transport in Skeletal Muscle

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Systemic Treatment with the Antidiabetic Drug Metformin Selectively Impairs p53-Deficient Tumor Cell Growth

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Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans

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mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

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The energy sensing LKB1–AMPK pathway regulates p27kip1 phosphorylation mediating the decision to enter autophagy or apoptosis

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Inappropriate Activation of the TSC/Rheb/mTOR/S6K Cassette Induces IRS1/2 Depletion, Insulin Resistance, and Cell Survival Deficiencies

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A Role for Autophagy in the Extension of Lifespan by Dietary Restriction in C. elegans

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The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span

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The Mammalian Target of Rapamycin (mTOR) Partner, Raptor, Binds the mTOR Substrates p70 S6 Kinase and 4E-BP1 through Their TOR Signaling (TOS) Motif

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An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten +/− mice

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Akt activates the mammalian target of rapamycin by regulating cellular ATP level and AMPK activity

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PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans

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TOS Motif-Mediated Raptor Binding Regulates 4E-BP1 Multisite Phosphorylation and Function

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AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons

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Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans

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Balancing Akt with S6K

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Yeast Life Span Extension by Depletion of 60S Ribosomal Subunits Is Mediated by Gcn4

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AMP-activated Protein Kinase Is Required for the Lipid-lowering Effect of Metformin in Insulin-resistant Human HepG2 Cells

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Effect of metformin on life span and on the development of spontaneous mammary tumors in HER-2/neu transgenic mice

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Important role of the LKB1-AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice

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The role of TOR in autophagy regulation from yeast to plants and mammals

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eIF4E function in somatic cells modulates ageing in Caenorhabditis elegans

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A rapid method for determining protein kinase phosphorylation specificity

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Cell Cycle Regulation via p53 Phosphorylation by a 5′-AMP Activated Protein Kinase Activator, 5-Aminoimidazole- 4-Carboxamide-1-β- -Ribofuranoside, in a Human Hepatocellular Carcinoma Cell Line

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Autophagy is Required for Dietary Restriction-Mediated Life Span Extension in<i>C. elegans</i>

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The TOR and EGO Protein Complexes Orchestrate Microautophagy in Yeast

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Activation of AMP-activated protein kinase inhibits protein synthesis associated with hypertrophy in the cardiac myocyte

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Thr2446 Is a Novel Mammalian Target of Rapamycin (mTOR) Phosphorylation Site Regulated by Nutrient Status*

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Prevention of pancreatic cancer induction in hamsters by metformin

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The Peutz-Jegher Gene Product LKB1 Is a Mediator of p53-Dependent Cell Death

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Coordination and communication between the p53 and IGF-1–AKT–TOR signal transduction pathways

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Caenorhabditis elegans dauers need LKB1/AMPK to ration lipid reserves and ensure long-term survival

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Elm1p Is One of Three Upstream Kinases for the Saccharomyces cerevisiae SNF1 Complex

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