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Cited by 342

The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.

Protective Efficacy of a Global HIV-1 Mosaic Vaccine against Heterologous SHIV Challenges in Rhesus Monkeys

Open access
Barouch, Dan H., Stephenson, Kathryn E., Borducchi, Erica N., Smith, Kaitlin, Stanley, Kelly, McNally, Anna G., Liu, Jinyan, Abbink, Peter, Maxfield, Lori F., Seaman, Michael S., Dugast, Anne-Sophie, Alter, Galit, Ferguson, Melissa, Li, Wenjun, Earl, Patricia L., Moss, Bernard, Giorgi, Elena E., Szinger, James J., Eller, Leigh Anne, Billings, Erik A., Rao, Mangala, Tovanabutra, Sodsai, Sanders-Buell, Eric, Weijtens, Mo, Pau, Maria G., Schuitemaker, Hanneke, Robb, Merlin L., Kim, Jerome H., Korber, Bette T., Michael, Nelson L.·2013·Cell
DOI 10.1016/j.cell.2013.09.061
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Abstract

SUMMARY The global diversity of HIV-1 represents a critical challenge facing HIV-1 vaccine development. HIV-1 mosaic antigens are bioinformatically optimized immunogens designed for improved coverage of HIV-1 diversity. However, the protective efficacy of global HIV-1 vaccine antigens has not previously been evaluated. Here we demonstrate the capacity of bivalent HIV-1 mosaic antigens to protect rhesus monkeys against acquisition of heterologous challenges with the difficult-to-neutralize simian-human immunodeficiency virus SHIV-SF162P3. Adenovirus/poxvirus and adenovirus/adenovirus vector-based vaccines expressing HIV-1 mosaic Env, Gag, and Pol afforded a significant reduction in the per-exposure acquisition risk following repetitive, intrarectal SHIV-SF162P3 challenges. Protection against acquisition of infection was correlated with vaccine-elicited binding, neutralizing, and functional non-neutralizing antibodies. These data demonstrate the protective efficacy of HIV-1 mosaic antigens and suggest a potential strategy towards the development of a global HIV-1 vaccine. Moreover, our findings suggest that the coordinated activity of multiple antibody functions may contribute to protection against difficult-to-neutralize viruses.

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Metadata

Authors
Barouch, D. H., Stephenson, K. E., Borducchi, E. N., Smith, K., Stanley, K., McNally, A. G., Liu, J., Abbink, P., Maxfield, L. F., Seaman, M. S., Dugast, A.-S., Alter, G., Ferguson, M., Li, W., Earl, P. L., Moss, B., Giorgi, E. E., Szinger, J. J., Eller, L. A., Billings, E. A., Rao, M., Tovanabutra, S., Sanders-Buell, E., Weijtens, M., Pau, M. G., Schuitemaker, H., Robb, M. L., Kim, J. H., Korber, B. T., & Michael, N. L.
Venue
Cell
Publisher
Elsevier BV
Published
2013-10
Volume
155
Issue
3
Pages
531-539
ISSN
0092-8674 (ISSN-L)
DOI
10.1016/j.cell.2013.09.061
OpenAlex
W2024608724
Cited by
342
References
33
FWCI
15.49
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Protective Efficacy of a Global HIV-1 Mosaic Vaccine against Heterologous SHIV Challenges in Rhesus Monkeys. https://app.cochat.ai/papers/10.1016/j.cell.2013.09.061
The paper
Barouch, D. H., Stephenson, K. E., Borducchi, E. N., Smith, K., Stanley, K., McNally, A. G., Liu, J., Abbink, P., Maxfield, L. F., Seaman, M. S., Dugast, A.-S., Alter, G., Ferguson, M., Li, W., Earl, P. L., Moss, B., Giorgi, E. E., Szinger, J. J., Eller, L. A., . . . Michael, N. L. (2013). Protective Efficacy of a Global HIV-1 Mosaic Vaccine against Heterologous SHIV Challenges in Rhesus Monkeys. Cell. https://doi.org/10.1016/j.cell.2013.09.061

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.