The DOI matches its Crossref record; 142 of the 143 references it cites were found in a registry or an index.
Mechanisms Governing Metastatic Dormancy and Reactivation
Open accessAbstract
Many cancer patients suffer from metastatic relapse several years after they have undergone radical surgery. Early cancer cell dissemination followed by a protracted period of dormancy potentially explains this prevalent clinical behavior. Increasing evidence suggests that the metastasis-initiating cells are cancer stem cells or revert to this functional state upon infiltrating a target organ. Their entry into dormancy and subsequent reactivation are governed by intrinsic programs and by contextual cues, which resemble those regulating the self-renewal capability of adult stem cells. In addition, metastatic cells undergoing reactivation are nursed by specialized extracellular matrix niches, which support positive signals, such as Wnt and Notch, and attenuate negative signals, such as BMP. In spite of significant remaining uncertainties, these findings provide a framework to understand the logic of metastatic dormancy and reactivation and open new avenues for therapeutic intervention.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The analogy between senescence and dormancy in some tumours also implies that the in vivo senescence-like arrest may be unstable, because dormant tumour cells can regrow after long periods of time 130,140”
From Inside and out: the activities of senescence in cancer (2014) · cites this paper as [140]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Epithelial-Mesenchymal Transitions in Development and Disease
Thiery, J. P., Acloque, H., Huang, R. Y. J., & Nieto, M. A. (2009) · Cell · doi:10.1016/j.cell.2009.11.007 · Cited by 9,931
Stem cells, cancer, and cancer stem cells
Reya, T., Morrison, S. J., Clarke, M. F., & Weissman, I. L. (2001) · Nature · doi:10.1038/35102167 · Cited by 9,738
The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells
Mani, S. A., Guo, W., Liao, M.-J., Eaton, E. N., Ayyanan, A., Zhou, A. Y., Brooks, M. W., Reinhard, F., Zhang, C. C., Shipitsin, M. V., et al. (2008) · Cell · doi:10.1016/j.cell.2008.03.027 · Cited by 8,839
Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing
Gerlinger, M., Rowan, A. J., Horswell, S., Larkin, J., Endesfelder, D., Gronroos, E., Martinez, P., Matthews, N., Stewart, A., Tarpey, P., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1113205 · Cited by 7,774
Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
Hanahan, D., & Folkman, J. (1996) · Cell · doi:10.1016/s0092-8674(00)80108-7 · Cited by 6,885
Nowell, P. C. (1976) · Science · doi:10.1126/science.959840 · Cited by 6,471
Wnt/β-catenin signaling and disease
Clevers, H., & Nusse, R. (2012) · Cell · doi:10.1016/j.cell.2012.05.012 · Cited by 5,554
A Perspective on Cancer Cell Metastasis
Chaffer, C. L., & Weinberg, R. A. (2011) · Science · doi:10.1126/science.1203543 · Cited by 4,905
The pathogenesis of cancer metastasis: the ‘seed and soil’ hypothesis revisited
Fidler, I. J. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1098 · Cited by 4,686
Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling
Levental, K. R., Yu, H., Kass, L., Lakins, J. N., Egeblad, M., Erler, J. T., Fong, S. F. T., Csiszar, K., Giaccia, A., Weninger, W., et al. (2009) · Cell · doi:10.1016/j.cell.2009.10.027 · Cited by 4,101
Cited by
Sorted by citations
Items 401–500 of 587
Signaling Pathways in Drosophila gonadal Stem Cells
Eslahi, M., Nematbakhsh, N., Dastmalchi, N., Teimourian, S., & Safaralizadeh, R. (2023) · Current Stem Cell Research & Therapy · doi:10.2174/1574888x18666230213144531 · Cited by 7
Kim, C.-Y., Lee, K.-H., Son, K. H., Shin, T.-J., & Cho, J. (2024) · Experimental & Molecular Medicine · doi:10.1038/s12276-024-01181-7 · Cited by 8
Distance-based classifiers as potential diagnostic and prediction tools for human diseases
Veytsman, B. A., Wang, L., Cui, T., Bruskin, S. A., & Baranova, A. V. (2014) · BMC Genomics · doi:10.1186/1471-2164-15-s12-s10 · Cited by 7
Contact Normalization or Escape from the Matrix
Krishnan, H., & Goldberg, G. S. (2015) · Springer eBooks · doi:10.1007/978-94-017-7380-5_12 · Cited by 7
Small Ones to Fight a Big Problem—Intervention of Cancer Metastasis by Small Molecules
Kobelt, D., Dahlmann, M., Dumbani, M., Güllü, N., Kortüm, B., Vílchez, M. E. A., Stein, U., & Walther, W. (2020) · Cancers · doi:10.3390/cancers12061454 · Cited by 7
Sensitization of Resistant Breast Cancer Cells with a Jumonji Family Histone Demethylase Inhibitor
Singh, B., Sarli, V. N., & Lucci, A. (2022) · Cancers · doi:10.3390/cancers14112631 · Cited by 8
Cancer Stem Cells and Their Therapeutic Usage
Osum, M., & Kalkan, R. (2023) · Advances in experimental medicine and biology · doi:10.1007/5584_2022_758 · Cited by 8
Yang, S., Zhang, W., Yuan, W.-S., & Dong, J. (2015) · Medicine · doi:10.1097/md.0000000000001062 · Cited by 7
Ikeda, M., & Toyoshima, F. (2016) · Molecular and Cellular Biology · doi:10.1128/mcb.00417-16 · Cited by 7
Qu, Y., Guo, B., Zhao, S., Sun, J., Cao, J. W., Xia, M., Zhong, Z., & Meng, F. (2025) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.113704 · Cited by 6
CD44 Marks Dormant Tumor Cells After HER2 Inhibition in Breast Cancer Cells
Vargas, C., Aguirre, A., Cereceda, K., Quijada, S., Escobar-Gómez, N., Castillo, R. L., & Escobar-Aguirre, M. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26104907 · Cited by 6
Ma, L., Wang, Y., Qiu, S., Shi, M., Tang, W., Hu, H., Li, C., Lu, H., & Wang, X. (2025) · Cell Death Discovery · doi:10.1038/s41420-025-02910-1 · Cited by 6
Prevention of Conversion of Tumor Dormancy into Proliferative Metastases
Barkan, D., & Chambers, A. F. (2016) · Current cancer research · doi:10.1007/978-1-4939-3363-1_7 · Cited by 6
Quayle, L. A., Spicer-Hadlington, A. R., Ottewell, P. D., & Holen, I. (2021) · Cancers · doi:10.3390/cancers13163922 · Cited by 6
Natural compounds as a potential modifier of stem cells renewal: Comparative analysis
Mishra, A., Pathak, Y., Mishra, S. K., Prakash, H., & Tripathi, V. (2022) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2022.175412 · Cited by 6
Umeshappa, C. S., Zhu, Y., Bhanumathy, K. K., Omabe, M., Chibbar, R., & Xiang, J. (2015) · Cancer Biotherapy and Radiopharmaceuticals · doi:10.1089/cbr.2014.1736 · Cited by 6
Epigenetic and Pluripotency Aspects of Disseminated Cancer Cells During Minimal Residual Disease
Carlini, M. J., Shrivastava, N., & Sosa, M. S. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-97746-1_1 · Cited by 6
Harada, M., Tsujimoto, H., Ichikura, T., Nagata, H., Ito, N., Nomura, S., Horiguchi, H., Yaguchi, Y., Kishi, Y., & Ueno, H. (2019) · Surgical Case Reports · doi:10.1186/s40792-019-0664-z · Cited by 6
González‐López, O., DeCotiis, J., Goyeneche, C., Mello, H. F., Vicente-Ortiz, B. A., Shin, H. J., Driscoll, K. E., Du, P., Palmeri, D., & Lukac, D. M. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.007331 · Cited by 6
Is Extracellular Matrix a Castle Against to Invasion of Cancer Cells?
Altınay, S. (2016) · InTech eBooks · doi:10.5772/64495 · Cited by 6
Endoplasmic Reticulum Stress in Bone Metastases
Xu, L., Zhang, W., Zhang, X. H.-F., & Chen, X. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.01100 · Cited by 6
de Souza, L. E. B., de Almeida, D. C., Yaochite, J. N. U., Covas, D. T., & Fontes, A. M. (2015) · Experimental Cell Research · doi:10.1016/j.yexcr.2015.05.021 · Cited by 6
The Darwinian Dynamics of Motility and Metastasis
Schiffman, J. D., White, R. M., Graham, T. A., Huang, Q., & Aktipis, A. (2016) · doi:10.1007/978-1-4939-6460-4_8 · Cited by 6
Lung endothelial PEAR1 induces tumor cell dormancy
Roquid, K. A., Vučetić, A., Dyukova, E., Hanssen, M. J., Cho, H., Bonnavion, R., Mattonet, K., Looso, M., Šanda, M., Strilić, B., et al. (2025) · Molecular Cancer · doi:10.1186/s12943-025-02488-3 · Cited by 5
Netrin signaling mediates survival of dormant epithelial ovarian cancer cells
Perampalam, P., MacDonald, J. I., Zakirova, K., Passos, D. T., Wasif, S., Ramos-Valdes, Y., Hervieu, M., Mehlen, P., Rottapel, R. K., Gibert, B., et al. (2023) · eLife · doi:10.7554/elife.91766 · Cited by 11
Identification and validation of a novel anoikis‐related prognostic model for prostate cancer
Zhang, P., Lv, W., Luan, Y., Cai, W., Min, X., & Feng, Z. (2024) · Molecular Genetics & Genomic Medicine · doi:10.1002/mgg3.2419 · Cited by 5
Integrating Nanorobotics with Biophysics for Cancer Treatment
Malviya, R., Yadav, D., Sundram, S., Kadry, S., & VIRK, G. S. (2024) · Institute of Physics eBooks · doi:10.1088/978-0-7503-6019-7 · Cited by 4
Dong, Z., She, X., Ma, J., Chen, Q., Gao, Y., Chen, R., Qin, H., Shen, B., & Gao, H. (2025) · Advanced Science · doi:10.1002/advs.202504704 · Cited by 5
Aurora Kinase Inhibitors in Breast Cancer Treatment
Opyrchal, M., Sangameswaran, K. D. G., Khoury, T., Boland, P. M., Galanis, E., Haddad, T. C., & D’Assoro, A. B. (2015) · American Journal of Hematology / Oncology® · Cited by 5
Multistep Process of Establishing Carcinoma Metastases
Ondroušková, E., Sommerová, L., & Hrstka, R. (2016) · Klinicka onkologie · doi:10.14735/amko20164s12 · Cited by 5
Modeling the Complexity of the Metastatic Niche Ex Vivo
Clark, A. M. (2020) · Methods in molecular biology · doi:10.1007/978-1-0716-1174-6_15 · Cited by 5
Tumor cell-organized fibronectin is required to maintain a dormant breast cancer populationPreprint
Barney, L. E., Hall, C. L., Schwartz, A. D., Parks, A. N., Sparages, C., Galarza, S., Platt, M. O., Mercurio, A. M., & Peyton, S. R. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/686527 · Cited by 5
Jiang, C., & Wu, J. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1412296 · Cited by 4
Elevated GRHL2 Imparts Plasticity in ER-Positive Breast Cancer Cells
Zheng, C., Allen, K. O., Liu, T., Solodin, N. M., Meyer, M. B., Salem, K., Tsourkas, P. K., McIlwain, S. J., Vera, J. M., Cromwell, E. R., et al. (2024) · Cancers · doi:10.3390/cancers16162906 · Cited by 4
Snail induces dormancy in disseminated luminal type A breast cancer through Src inhibition.
Ho, C.-T., Lin, S., Tseng, L., Hung, M., & Hung, S. (2022) · PubMed Central · Cited by 4
The role of hypoxia and radiation in developing a CTCs-like phenotype in murine osteosarcoma cells
Quartieri, M., Puspitasari, A., Vitacchio, T., Durante, M., & Tinganelli, W. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1222809 · Cited by 5
Inertial effect of cell state velocity on the quiescence-proliferation fate decision
Venkatachalapathy, H., Brzakala, C., Batchelor, E., Azarin, S. M., & Sarkar, C. A. (2024) · npj Systems Biology and Applications · doi:10.1038/s41540-024-00428-3 · Cited by 4
An Update and Translational Perspective in Genetics and Genomics of Breast Cancer
Umadevi, K., Priyanka, L. G., Clementina, R., Rao, E. S., Sundeep, D., & Kumari, S. (2025) · Current Breast Cancer Reports · doi:10.1007/s12609-024-00567-w · Cited by 4
Jiang, C., Starr, S., Chen, F., & Wu, J. (2016) · Future Oncology · doi:10.2217/fon-2016-0066 · Cited by 4
Saeed, M. U., Hussain, N., Zulfiqar, I., Raza, A., Ghauri, M. A., & Bilal, M. (2022) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2022.103645 · Cited by 4
Case Report: Pancreatic metastasis of renal cell carcinoma 16 years after nephrectomy
Lou, Y., Guo, K., & Zheng, S. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1091635 · Cited by 4
Metastasis suppressor genes and their role in the tumor microenvironment
Megino‐Luque, C., & Bravo‐Cordero, J. J. (2023) · Cancer and Metastasis Reviews · doi:10.1007/s10555-023-10155-6 · Cited by 4
Yasuda, T., Hayashi, S., Nakahata, Y., Yasuda, Y. L., Omatsu, T., Obora, A., Kojima, T., & Yagi, N. (2020) · Internal Medicine · doi:10.2169/internalmedicine.3847-19 · Cited by 4
Ohta, R., & Okamoto, M. (2021) · Nihon Reoroji Gakkaishi · doi:10.1678/rheology.49.163 · Cited by 4
Yu, Y., Liu, W., Zhan, X., Zhong, Y., Feng, Y., Cao, Q., & Tan, B. (2022) · PubMed Central · Cited by 4
Models of Melanoma Spread and Final Results of the Multicenter Selective Lymphadenectomy Trial-I
Pizarro, Á. (2015) · Actas Dermo-Sifiliográficas · doi:10.1016/j.adengl.2014.12.001 · Cited by 4
Molecular Basis of Bone Diseases
Galliera, E., & Romanelli, M. M. C. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-802761-5.00028-6 · Cited by 4
Eliminating Mycobacterial Persistence: Novel Targets for Anti-TB Therapy
Bhaskar, A., Dwivedi, V. P., & Nandicoori, V. K. (2019) · Springer eBooks · doi:10.1007/978-981-32-9449-3_3 · Cited by 4
Tumor Cell Dormancy: Threat or Opportunity in the Fight against CancerPreprint
Seidi, K., Manjili, M. H., Jahanban‐Esfahlan, R., & Javaheri, T. (2018) · Preprints.org · doi:10.20944/preprints201810.0225.v1 · Cited by 4
Lee, G. H., Lee, S. Y., Baek, Y.-W., Lim, J., Chung, K. H., & Jeong, H. G. (2025) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2025.117930 · Cited by 3
Pulido, I., García‐Cañaveras, J. C., Rodríguez, M. L., Becker, J. H., López, A., Aupí, M., Aparisi, S., Chuliá‐Peris, L., Tamayo-Torres, E., Carreres-Rey, C., et al. (2025) · Cancer Letters · doi:10.1016/j.canlet.2025.218032 · Cited by 3
Innate immunity in tumour immunoediting and immunosurveillance
Zhang, Z., Zhang, Y., & Lieberman, J. (2025) · The EMBO Journal · doi:10.1038/s44318-025-00650-7 · Cited by 4
Mittelman, L. E., Vargas, L. O., Abikenari, M. A., Latzman, S., Chen, J., Rangavajhula, K., Syed, S. A., Santhumayor, B. A., Duehr, J. E., Cassimatis, N., et al. (2026) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2026.111928 · Cited by 3
Tumor Deposits; Mechanisms, Morphology, and Differential Diagnosis
Sarıoğlu, S. (2018) · Springer eBooks · doi:10.1007/978-3-319-68582-3_2 · Cited by 3
Beware of thy neighbor: Senescent cancer cells feast on adjacent cells to persist
Napoli, M., & Flores, E. R. (2019) · The Journal of Cell Biology · doi:10.1083/jcb.201910040 · Cited by 3
Biomaterial-Mediated Drug Delivery in Primary and Metastatic Cancers of the Bone
Forde, P. F., & Ryan, K. B. (2017) · Springer eBooks · doi:10.1007/978-3-319-73664-8_20 · Cited by 3
Late recurrence of gastric carcinoma 15 years after surgery
Ogasawara, N., Ohkura, Y., Ueno, M., Haruta, S., Nakayama, A., Fujii, T., Honda, A., Tanaka, T., & Udagawa, H. (2020) · Clinical Journal of Gastroenterology · doi:10.1007/s12328-020-01143-2 · Cited by 3
Bellone, M., & Caputo, S. (2019) · Resistance to targeted anti-cancer therapeutics · doi:10.1007/978-3-030-16624-3_8 · Cited by 3
Dormancy: An Evolutionary Key Phenomenon in Cancer Development a
Ammerpohl, O., Hattermann, K., Held‐Feindt, J., Röcken, C., Schäfer, H., Schem, C., Schewe, D. M., Schulenburg, H., Sebens, S., Synowitz, M., et al. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-804310-3.00020-x · Cited by 3
Hnit, S. S. T., Bi, L., Xie, C., Xu, L., Zhong, Y., Yang, M., Wang, Y., & Dong, Q. (2025) · Drug Design Development and Therapy · doi:10.2147/dddt.s494168 · Cited by 2
Simon, I., Sanchez-Manas, J. M., Perales, S., Martínez-Navajas, G., Ceron-Hernandez, J., & Real, P. J. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26135939 · Cited by 3
Liao, W., Yin, R., Zuo, F., Li, Y., Deng, J., Li, Y., Li, X., 陶德定, Luo, X. P., 季维克, et al. (2026) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-026-03754-y · Cited by 2
Metastasis and cancer dormancy
Kharchenko, E. P., & Solovev, I. A. (2016) · P A Herzen Journal of Oncology · doi:10.17116/onkolog20165572-77 · Cited by 2
Ferlini, L., Peluso, L., Lolli, V. E., Gaspard, N., & Lefranc, F. (2021) · Oncology Letters · doi:10.3892/ol.2021.12715 · Cited by 2
Molecular and Immune Phenotypic Modifications during Metastatic Dissemination in Lung Carcinogenesis
Tsavlis, D., Katopodi, T., Anestakis, D., Petanidis, S., Charalampidis, C., Chatzifotiou, E., Eskitzis, P., Zarogoulidis, P., & Porpodis, Κ. (2022) · Cancers · doi:10.3390/cancers14153626 · Cited by 2
LIN, Y., Coppo, R., Onuma, K., Endo, H., Kondo, J., Iwabuchi, S., Hashimoto, S., Itatani, Y., Obama, K., & Inoue, M. (2024) · Cancer Science · doi:10.1111/cas.16299 · Cited by 2
Cancer Cells in Sleep Mode: Wake Them to Eliminate or Keep Them Asleep Forever?
Liu, W., Kovacs, A. H., & Hou, J. (2024) · Cells · doi:10.3390/cells13232022 · Cited by 12
Serum EMMPRIN/CD147 promotes the lung pre-metastatic niche in a D2A1 mammary carcinoma mouse model
Feigelman, G., Simanovich, E., & Rahat, M. A. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1568578 · Cited by 2
Hassan, M., El‐Khattouti, A., Haïkel, Y., Institut National de la Santé et de la Recherche Médicale, U. 9., & Megahed, M. (2014) · International Journal of Stem Cell Research and Transplantation · doi:10.19070/2328-3548-1400013 · Cited by 2
Cellular Plasticity, Cancer Stem Cells and Metastasis
Ferrari, P., & Nicolini, A. (2015) · Springer eBooks · doi:10.1007/978-3-319-21030-8_2 · Cited by 2
Resolution of Metastatic Colon Cancer upon Withdrawal of Anti-TNF Therapy for Crohn’s Disease
Wiksyk, B., Joe, H., Fenton, D. W., Kelly, J. K., & Truong, P. T. (2018) · Journal of Gastrointestinal Cancer · doi:10.1007/s12029-018-0107-2 · Cited by 2
Toward radiotheranostics in cancer stem cells: a promising initial step for tumour eradication
Ghaderi, F., Jokar, N., Gholamrezanezhad, A., Assadi, M., & Ahmadzadehfar, H. (2021) · Clinical and Translational Imaging · doi:10.1007/s40336-021-00444-x · Cited by 2
Sharif, P. M., Khoshbin, A. P., Nasrollahzadeh, E., Keshavarz‐Fathi, M., & Rezaei, N. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-818006-8.00003-7 · Cited by 3
Integrin α6: a potential target for cancer molecular imaging and targeting therapy
Li, X., Shen, Z., Wang, Q., Ye, J., Zhang, W., Li, Y., Feng, G., & Zeng, M. (2023) · Malignancy Spectrum · doi:10.1002/msp2.18 · Cited by 2
Chemokine Ligand 2 – Chemokines Receptor 2 As A Noval Drug Target
Gamit, K. S. (2022) · Open Access Journal of Toxicology · doi:10.19080/oajt.2022.05.555665 · Cited by 1
Metastasis Models: Thermodynamics and Complexity
Guerra, A., Betancourt-Mar, J. A., Llanos-Pérez, J. A., Mansilla, R., & Nieto-Villar, J. M. (2023) · Methods in molecular biology · doi:10.1007/978-1-0716-3577-3_4 · Cited by 1
Significance of EVs in Prostate Cancer Bone Metastases
Ito, K., Tamura, T., Urabe, F., Sakamoto, S., Kimura, T., Egawa, S., & Ochiya, T. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262412160 · Cited by 1
Changes in Cancer Stem Cell Signalling Pathways With Plant Metabolites to Discover Chemotherapy
Rizvi, A., Farhan, M., Ahmad, A. R., & Aatif, M. (2026) · Chemistry & Biodiversity · doi:10.1002/cbdv.71378 · Cited by 1
Epithelial-mesenchymal transition and immunosuppression: Two sides of the same coin
Feng, B., & Dongre, A. (2026) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-026-06240-y · Cited by 2
Mediator Subunit Med4 Enforces Metastatic Dormancy in Breast Cancer
Bae, S.-Y., Ling, H.-H., Zhang, J., Chen, Y., Chen, H., Kumar, D., Saw, A., Rai, K., Viny, A., DePinho, R., et al. (2023) · bioRxiv · doi:10.1038/s41556-026-01984-y · Cited by 1
Self-citationSeaman, J. L., Twilley, D., & Lall, N. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1821643 · Cited by 1
Arlt, M., Banke, J. I., Walters, D. K., Berndt, K., Strehler, E. E., Born, W., & Fuchs, B. (2014) · Journal of Cancer Research & Therapy · doi:10.14312/2052-4994.2014-13 · Cited by 1
Sarıoğlu, S. (2018) · Springer eBooks · doi:10.1007/978-3-319-68582-3_1 · Cited by 1
Metastasis: A Major Driver of Cancer Pathogenesis
Cheema, P. S., Kumar, G., Mittal, S., Parashar, D., Geethadevi, A., Jadhav, K., & Tuli, H. S. (2020) · Springer eBooks · doi:10.1007/978-981-15-7586-0_10 · Cited by 1
Park, J. M., Kangwan, N., Kim, E. H., Chung, M. K., Han, Y., Kwon, S. H., Kwon, C., & Hahm, K. B. (2014) · Springer eBooks · doi:10.1007/978-3-319-12253-3_23 · Cited by 1
Cancer Cell De-Differentiation: Plasticity-Driven Stratagem For Tumor Metastasis and Recurrence
Marsafy, S. E., & Larghero, J. (2022) · Current Stem Cell Research & Therapy · doi:10.2174/1574888x17666220608101852 · Cited by 3
The Metabolism of Cancer Cells During Metastasis
Farshbafnadi, M., & Rezaei, N. (2023) · Springer eBooks · doi:10.1007/978-3-030-80962-1_60-1 · Cited by 1
Therapeutics Targeting Cancer Stem Cell Signalling Pathways
Punnasseril, J. M. J., Gopalan, V., & Islam, F. (2023) · Springer eBooks · doi:10.1007/978-981-99-3185-9_11 · Cited by 1
Cancer Metastasis, ROS/Redox Signaling, and PCD Resistance/Redox Metabolism
Bansal, M. P. (2023) · Springer eBooks · doi:10.1007/978-981-99-7342-2_5 · Cited by 1
A case of multiple lung metastases diagnosed 18 years after surgery for cervical adenocarcinoma
Ryo, T., Kitagawa, T., Mori, S., & Shigemitsu, K. (2024) · The Journal of the Japanese Association for Chest Surgery · doi:10.2995/jacsurg.38.93 · Cited by 1
NCOR2 represses MHC class I molecule expression to drive metastatic progression of breast cancer
Ticha, P., Northey, J. J., Narain, R., Sharma, S., Lakins, J. N., Gonzalez, H., Kersten, K., Ironside, A. J., Drain, A. P., Zidek, M., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-72168-3 · Cited by 1
Therapeutics of Oxidative Stress and Stemness in Breast Cancer
Singh, B., Mujoo, K., & Lucci, A. (2022) · Springer eBooks · doi:10.1007/978-981-15-9411-3_117 · Cited by 1
The Role and Regulation of Quiescence in Acute Lymphoblastic Leukaemia
Williams, R., & Gordon, P. M. (2017) · EMJ Hematology · doi:10.33590/emjhematol/10311523 · Cited by 1
CANCER STEM CELLS: THE GREATEST MENACE IN CONQUERING CANCER MANAGEMENT
Brahmbhatt, J., Bhadresha, K. P., Mehta, D., & Rawal, R. (2022) · Towards Excellence · doi:10.37867/te140189 · Cited by 1
Transplantation for hepatocellular carcinoma—worth waiting for?
Pennycuick, A., Suddle, A. R., & Villanueva, A. (2014) · Liver Transplantation · doi:10.1002/lt.23943 · Cited by 1
Nam, M., Nam, M., Yang, W., Lee, J. Y., Choi, J., Choi, H., Yu, E., Kim, E., Hwang, J. Y., Bae, W. H., et al. (2020) · Regular and Young Investigator Award Abstracts · doi:10.1136/jitc-2020-sitc2020.0752 · Cited by 1
Kumar, D., & Giancotti, F. G. (2021) · Regular and Young Investigator Award Abstracts · doi:10.1136/jitc-2021-sitc2021.931 · Cited by 1
Self-citationHan, H., Wang, Y., Curto, J., Gurrapu, S., Laudato, S., Rumandla, A., Chakraborty, G., Wang, X., Chen, H., Jiang, Y., et al. (2021) · Research Square · doi:10.1101/2021.04.14.439569 · Cited by 1
Self-citationNetrin signaling mediates survival of dormant epithelial ovarian cancer cellsPreprint
Perampalam, P., MacDonald, J. I., Zakirova, K., Passos, D. T., Wasif, S., Ramos-Valdes, Y., Hervieu, M., Mehlen, P., Rottapel, R. K., Gibert, B., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.08.29.555435 · Cited by 1
Cellular Response to an Act of Surviving Drives Tumor Evolution and Tumor HeterogeneityPreprint
Zhang, Y. (2023) · Preprints.org · doi:10.20944/preprints202310.1417.v1
Metadata
- Authors
- Giancotti, F. G.
- Affiliations
- Memorial Sloan Kettering Cancer Center (US)
- Corresponding author
- Giancotti, Filippo G.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2013-11
- Volume
- 155
- Issue
- 4
- Pages
- 750-764
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC4354734
- OpenAlex
- W2088035579
- Cited by
- 586
- References
- 143
- Citations by year
- 2026: 20 · 2025: 35 · 2024: 45 · 2023: 68 · 2022: 47 · 2021: 50 · 2020: 53 · 2019: 47 · 2018: 53 · 2017: 39 · 2016: 57 · 2015: 44 · 2014: 28
- FWCI
- 4.54
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (R01CA175712)
- Topics
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mechanisms of cancer metastasis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- metastatic dormancy, cancer stem cells, metastasis-initiating cells, Wnt signaling, Notch signaling, BMP signaling, metastatic relapse, therapeutic interventions
- MeSH terms
- Animals, Extracellular Matrix, Humans, Neoplasm Metastasis, Neoplasms, Neoplastic Stem Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review