Cited by 361Memory and Neural MechanismsMemory Processes and InfluencesPosttraumatic Stress Disorder Research

The DOI matches its Crossref record; 74 of the 75 references it cites were found in a registry or an index.

Epigenetic Priming of Memory Updating during Reconsolidation to Attenuate Remote Fear Memories

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Abstract

Traumatic events generate some of the most enduring forms of memories. Despite the elevated lifetime prevalence of anxiety disorders, effective strategies to attenuate long-term traumatic memories are scarce. The most efficacious treatments to diminish recent (i.e., day-old) traumata capitalize on memory updating mechanisms during reconsolidation that are initiated upon memory recall. Here, we show that, in mice, successful reconsolidation-updating paradigms for recent memories fail to attenuate remote (i.e., month-old) ones. We find that, whereas recent memory recall induces a limited period of hippocampal neuroplasticity mediated, in part, by S-nitrosylation of HDAC2 and histone acetylation, such plasticity is absent for remote memories. However, by using an HDAC2-targeting inhibitor (HDACi) during reconsolidation, even remote memories can be persistently attenuated. This intervention epigenetically primes the expression of neuroplasticity-related genes, which is accompanied by higher metabolic, synaptic, and structural plasticity. Thus, applying HDACis during memory reconsolidation might constitute a treatment option for remote traumata.

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Crossref · 10.1016/j.cell.2013.12.020

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Research works printed but not linked: 2

  1. Trapnell, 2013, Differential analysis of gene regulation at transcript resolution with RNA-seq, Nat. Biotechnol., 31, 46, 10.1038/nbt.2450 · DOI · Paper page
  2. Tsai, 2012, Use of CI-994 and dinaline for the treatment of memory/cognition and anxiety disorders, U.S. patent 8, 563

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Metadata

Authors
Gräff, J., Joseph, N. F., Horn, M. E., Samiei, A., Meng, J., Seo, J., Rei, D., Bero, A. W., Phan, T. X., Wagner, F., Holson, E., Xu, J., Sun, J., Neve, R. L., Mach, R. H., Haggarty, S. J., & Tsai, L.-H.
Affiliations
  • Broad Institute (US)
  • Howard Hughes Medical Institute (US)
  • Massachusetts Institute of Technology (US)
  • Washington University in St. Louis (US)
Corresponding author
Tsai, Li-Huei
Venue
Cell
Publisher
Elsevier BV
Published
2014-01
Volume
156
Issue
1-2
Pages
261-276
ISSN
0092-8674 (ISSN-L)
OpenAlex
W2021415039
Cited by
357
References
75
Citations by year
2026: 13 · 2025: 22 · 2024: 21 · 2023: 20 · 2022: 28 · 2021: 27 · 2020: 25 · 2019: 22 · 2018: 45 · 2017: 32 · 2016: 34 · 2015: 32 · 2014: 36
FWCI
22.87
Type
journal article
Language
en
Open access
Locations
  • Cell (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc-nd)
  • Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
  • Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
Funders
  • Howard Hughes Medical Institute
  • National Institutes of Health
  • National Institute on Aging
  • National Institute on Drug Abuse (R01DA028301)
  • National Institute of Neurological Disorders and Stroke (NS078839, R03NS090214, R01NS078839)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
  • Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
Keywords
memory reconsolidation, HDAC2, S-nitrosylation, histone acetylation, hippocampal plasticity, histone deacetylase inhibitors, anxiety disorders, memory retrieval, synaptic plasticity
MeSH terms
Animals, Fear, Hippocampus, Male, Mice, Inbred C57BL, Neuronal Plasticity, Epigenesis, Genetic, Mice, Histone Deacetylase 2, Histone Deacetylase Inhibitors, Memory, Long-Term, Transcriptome

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