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Epigenetic Priming of Memory Updating during Reconsolidation to Attenuate Remote Fear Memories
Open accessAbstract
Traumatic events generate some of the most enduring forms of memories. Despite the elevated lifetime prevalence of anxiety disorders, effective strategies to attenuate long-term traumatic memories are scarce. The most efficacious treatments to diminish recent (i.e., day-old) traumata capitalize on memory updating mechanisms during reconsolidation that are initiated upon memory recall. Here, we show that, in mice, successful reconsolidation-updating paradigms for recent memories fail to attenuate remote (i.e., month-old) ones. We find that, whereas recent memory recall induces a limited period of hippocampal neuroplasticity mediated, in part, by S-nitrosylation of HDAC2 and histone acetylation, such plasticity is absent for remote memories. However, by using an HDAC2-targeting inhibitor (HDACi) during reconsolidation, even remote memories can be persistently attenuated. This intervention epigenetically primes the expression of neuroplasticity-related genes, which is accompanied by higher metabolic, synaptic, and structural plasticity. Thus, applying HDACis during memory reconsolidation might constitute a treatment option for remote traumata.
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“CI-994 is an orally active class I HDAC inhibitor that has undergone several phase II/III clinical trials on cancer treatment.”
From CI-994 is a dual modulator of class I HDACs and Wnt/β-catenin signaling for the treatment of Alzheimer's disease (2026) · cites this paper as [17]
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“CI-994 can cross the blood–brain barrier and is a cognitive enhancer.”
From CI-994 is a dual modulator of class I HDACs and Wnt/β-catenin signaling for the treatment of Alzheimer's disease (2026) · cites this paper as [17]
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“CI-994 is a molecular memory aid and promotes memory formation and cognitive function in vivo [9, 17, 21–24].”
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“CI-994 is an orally bioavailable specific class I HDAC inhibitor which can across the blood–brain barrier [16, 17].”
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“CI-994 acts as a memory enhancer and alleviates cognitive deficits in mouse models of neurodegenerative disorders [9, 17, 21–24].”
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Citations
Cites
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860
Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing
Benjamini, Y., & Hochberg, Y. (1995) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1995.tb02031.x · Cited by 109,482
The Sequence Alignment/Map format and SAMtools
Li, H., Handsaker, B., Wysoker, A., Fennell, T., Ruan, J., Homer, N., Marth, G., Abecasis, G., Durbin, R., & 1000 Genome Project Data Processing Subgroup (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp352 · Cited by 62,041
Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
Huang, D. W., Sherman, B. T., & Lempicki, R. A. (2009) · Nature Protocols · doi:10.1038/nprot.2008.211 · Cited by 35,890
Ultrafast and memory-efficient alignment of short DNA sequences to the human genome.
Langmead, B., Trapnell, C., Pop, M., & Salzberg, S. L. (2009) · Genome Biology · doi:10.1186/gb-2009-10-3-r25 · Cited by 21,849
Kessler, R. C., Berglund, P., Demler, O., Jin, R., Merikangas, K. R., & Walters, E. E. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.6.593 · Cited by 20,391
(1982) · Trends in Neurosciences · doi:10.1016/0166-2236(82)90076-5 · Cited by 9,150
Emotional processing of fear: Exposure to corrective information.
Foa, E. B., & Kozak, M. J. (1986) · Psychological Bulletin · doi:10.1037/0033-2909.99.1.20 · Cited by 5,396
The molecular biology of memory storage: a dialogue between genes and synapses
Kandel, E. R. (2001) · Science · doi:10.1126/science.1067020 · Cited by 3,917
Differential analysis of gene regulation at transcript resolution with RNA-seq
Trapnell, C., Hendrickson, D. G., Sauvageau, M., Goff, L., Rinn, J. L., & Pachter, L. (2013) · Nature Biotechnology · doi:10.1038/nbt.2450 · Cited by 3,492
Fear memories require protein synthesis in the amygdala for reconsolidation after retrieval
Nader, K., Schafe, G. E., & Le Doux, J. E. (2000) · Nature · doi:10.1038/35021052 · Cited by 2,706
The organization of recent and remote memories
Frankland, P. W., & Bontempi, B. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1607 · Cited by 2,138
Memory consolidation, retrograde amnesia and the hippocampal complex
Nadel, L., & Moscovitch, M. (1997) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(97)80010-4 · Cited by 1,924
Zăgrean, L. (2014) · Acta Endocrinologica (Bucharest) · doi:10.4183/aeb.2014.529 · Cited by 1,922
Context, time, and memory retrieval in the interference paradigms of Pavlovian learning
Bouton, M. E. (1993) · Psychological Bulletin · doi:10.1037/0033-2909.114.1.80 · Cited by 1,896
Context and Behavioral Processes in Extinction: Table 1.
Bouton, M. E. (2004) · Learning & Memory · doi:10.1101/lm.78804 · Cited by 1,808
Neurobiological Basis of Failure to Recall Extinction Memory in Posttraumatic Stress Disorder
Milad, M. R., Pitman, R. K., Ellis, C. B., Gold, A. L., Shin, L. M., Lasko, N. B., Zeidan, M. A., Handwerger, K., Orr, S. P., & Rauch, S. L. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.06.026 · Cited by 1,339
Preventing the return of fear in humans using reconsolidation update mechanisms
Schiller, D., Monfils, M.-H., Raio, C. M., Johnson, D. C., LeDoux, J. E., & Phelps, E. A. (2010) · Nature · doi:10.1038/nature08637 · Cited by 1,248
Recovery of learning and memory is associated with chromatin remodelling
Fischer, A., Sananbenesi, F., Wang, X., Dobbin, M., & Tsai, L.-H. (2007) · Nature · doi:10.1038/nature05772 · Cited by 1,227
Self-citationMemory Reconsolidation and Extinction Have Distinct Temporal and Biochemical Signatures
Suzuki, A., Josselyn, S. A., Frankland, P. W., Masushige, S., Silva, A. J., & Kida, S. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.5491-03.2004 · Cited by 1,127
The Involvement of the Anterior Cingulate Cortex in Remote Contextual Fear Memory
Frankland, P. W., Bontempi, B., Talton, L. E., Kaczmarek, L., & Silva, A. J. (2004) · Science · doi:10.1126/science.1094804 · Cited by 1,001
Extinction-Reconsolidation Boundaries: Key to Persistent Attenuation of Fear Memories
Monfils, M.-H., Cowansage, K. K., Klann, E., & LeDoux, J. E. (2009) · Science · doi:10.1126/science.1167975 · Cited by 960
Misanin, J. R., Miller, R. R., & Lewis, D. J. (1968) · Science · doi:10.1126/science.160.3827.554 · Cited by 872
An epigenetic blockade of cognitive functions in the neurodegenerating brain
Gräff, J., Rei, D., Guan, J.-S., Wang, W.-Y., Seo, J., Hennig, K. M., Nieland, T. J. F., Fass, D. M., Kao, P. F., Kahn, M., et al. (2012) · Nature · doi:10.1038/nature10849 · Cited by 853
Self-citationDo thin spines learn to be mushroom spines that remember?
Bourne, J., & Harris, K. M. (2007) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2007.04.009 · Cited by 843
Dendritic Spine Pathology: Cause or Consequence of Neurological Disorders?
Fiala, J. C., Spacek, J., & Harris, K. M. (2002) · Brain Research Reviews · doi:10.1016/s0165-0173(02)00158-3 · Cited by 811
A single standard for memory: The case for reconsolidation
Nader, K., & Hardt, O. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2590 · Cited by 811
Molecular mechanisms of memory reconsolidation
Tronson, N. C., & Taylor, J. R. (2007) · Nature reviews. Neuroscience · doi:10.1038/nrn2090 · Cited by 810
Neuron-glia metabolic coupling and plasticity
Magistretti, P. J. (2006) · Experimental Physiology · doi:10.1113/expphysiol.2010.053157 · Cited by 781
Cellular and Systems Reconsolidation in the Hippocampus
Dębiec, J., LeDoux, J. E., & Nader, K. (2002) · Neuron · doi:10.1016/s0896-6273(02)01001-2 · Cited by 772
Reinstatement of fear to an extinguished conditioned stimulus.
Rescorla, R. A., & Heth, C. D. (1975) · Journal of Experimental Psychology Animal Behavior Processes · doi:10.1037/0097-7403.1.1.88 · Cited by 768
Epigenetic mechanisms in memory formation
Levenson, J. M., & Sweatt, J. D. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1604 · Cited by 767
Time-dependent reorganization of brain circuitry underlying long-term memory storage
Bontempi, B., Laurent-Demir, C., Destrade, C., & Jaffard, R. (1999) · Nature · doi:10.1038/23270 · Cited by 673
Mahan, A. L., & Ressler, K. J. (2011) · Trends in Neurosciences · doi:10.1016/j.tins.2011.06.007 · Cited by 643
Activity-dependent regulation of inhibitory synapse development by Npas4
Lin, Y., Bloodgood, B. L., Hauser, J. L., Lapan, A. D., Koon, A. C., Kim, T.-K., Hu, L. S., Malik, A. N., & Greenberg, M. E. (2008) · Nature · doi:10.1038/nature07319 · Cited by 639
Dynamics of Retrieval Strategies for Remote Memories
Goshen, I., Brodsky, M., Prakash, R., Wallace, J. L., Gradinaru, V., Ramakrishnan, C., & Deisseroth, K. A. (2011) · Cell · doi:10.1016/j.cell.2011.09.033 · Cited by 581
Bredy, T. W., Wu, H., Crego, C., Zellhoefer, J., Sun, Y. E., & Barad, M. (2007) · Learning & Memory · doi:10.1101/lm.500907 · Cited by 548
Brownell, J. E., & Allis, C. D. (1996) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(96)80048-7 · Cited by 534
Changing Fear: The Neurocircuitry of Emotion Regulation
Hartley, C. A., & Phelps, E. A. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.121 · Cited by 528
Calcium-Permeable AMPA Receptor Dynamics Mediate Fear Memory Erasure
Clem, R. L., & Huganir, R. L. (2010) · Science · doi:10.1126/science.1195298 · Cited by 516
A Memory Retrieval-Extinction Procedure to Prevent Drug Craving and Relapse
Xue, Y.-X., Luo, Y.-X., Wu, P., Shi, H.-S., Xue, L.-F., Chen, C., Zhu, W.-L., Ding, Z.-B., Bao, Y.-P., Shi, J., et al. (2012) · Science · doi:10.1126/science.1215070 · Cited by 511
Role of conditioned contextual stimuli in reinstatement of extinguished fear.
Bouton, M. E., & Bolles, R. C. (1979) · Journal of Experimental Psychology Animal Behavior Processes · doi:10.1037//0097-7403.5.4.368 · Cited by 481
New views of Arc, a master regulator of synaptic plasticity
Shepherd, J. D., & Bear, M. F. (2011) · Nature Neuroscience · doi:10.1038/nn.2708 · Cited by 481
Temporally graded requirement for protein synthesis following memory reactivation
Milekic, M. H., & Alberini, C. M. (2002) · Neuron · doi:10.1016/s0896-6273(02)00976-5 · Cited by 455
S-nitrosylation of histone deacetylase 2 induces chromatin remodelling in neurons
Nott, A., Watson, P. M., Robinson, J. D., Crepaldi, L., & Riccio, A. (2008) · Nature · doi:10.1038/nature07238 · Cited by 434
Activation of immediate early genes and memory formation
Tischmeyer, W., & Grimm, R. (1999) · Cellular and Molecular Life Sciences · doi:10.1007/s000180050315 · Cited by 422
A critical role for IGF-II in memory consolidation and enhancement
Chen, D. Y., Stern, S. A., García‐Osta, A., Saunier-Rebori, B., Pollonini, G., Bambah-Mukku, D., Blitzer, R. D., & Alberini, C. M. (2011) · Nature · doi:10.1038/nature09667 · Cited by 421
Opposite effects of fear conditioning and extinction on dendritic spine remodelling.
Lai, C. S. W., Franke, T. F., & Gan, W.-B. (2012) · Nature · doi:10.1038/nature10792 · Cited by 392
Arc in synaptic plasticity: from gene to behavior
Korb, E., & Finkbeiner, S. (2011) · Trends in Neurosciences · doi:10.1016/j.tins.2011.08.007 · Cited by 388
Rescorla, R. A. (2004) · Learning & Memory · doi:10.1101/lm.77504 · Cited by 380
Epigenetic regulation of gene expression in physiological and pathological brain processes
Gräff, J., Kim, D., Dobbin, M. M., & Tsai, L.-H. (2011) · Physiological Reviews · doi:10.1152/physrev.00012.2010 · Cited by 373
Self-citationConsolidation and Reconsolidation: Two Lives of Memories?
McKenzie, S., & Eichenbaum, H. (2011) · Neuron · doi:10.1016/j.neuron.2011.06.037 · Cited by 368
EARLY INTERVENTIONS FOR PTSD: A REVIEW: Review: Early Intervention
Kearns, M. C., Ressler, K. J., Zatzick, D., & Rothbaum, B. O. (2012) · Depression and Anxiety · doi:10.1002/da.21997 · Cited by 310
Npas4 Regulates a Transcriptional Program in CA3 Required for Contextual Memory Formation
Ramamoorthi, K., Fropf, R., Belfort, G. M., Fitzmaurice, H. L., McKinney, R. M., Neve, R. L., Otto, T., & Lin, Y. (2011) · Science · doi:10.1126/science.1208049 · Cited by 305
Self-citationMemory Retrieval and the Passage of Time: From Reconsolidation and Strengthening to Extinction
Inda, M. C., Muravieva, E. V., & Alberini, C. M. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.4736-10.2011 · Cited by 261
Bredy, T. W., & Barad, M. (2008) · Learning & Memory · doi:10.1101/lm.801108 · Cited by 260
Stability of recent and remote contextual fear memory
Frankland, P. W., Ding, H.-K., Takahashi, E., Suzuki, A., Kida, S., & Silva, A. J. (2006) · Learning & Memory · doi:10.1101/lm.183406 · Cited by 259
Systemic or intrahippocampal delivery of histone deacetylase inhibitors facilitates fear extinction.
Lattal, K. M., Barrett, R. M., & Wood, M. A. (2007) · Behavioral Neuroscience · doi:10.1037/0735-7044.121.5.1125 · Cited by 243
Psychosocial treatment of posttraumatic stress disorder.
Foa, E. B. (2000) · PubMed · Cited by 210
Increasing Histone Acetylation in the Hippocampus-Infralimbic Network Enhances Fear Extinction
Stafford, J. M., Raybuck, J. D., Ryabinin, A. E., & Lattal, K. M. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.12.012 · Cited by 168
A hippocampal insulin‐growth factor 2 pathway regulates the extinction of fear memories
Agís‐Balboa, R. C., Arcos-Díaz, D. P., Wittnam, J. L., Govindarajan, N., Blom, K., Burkhardt, S., Haladyniak, U., Agbemenyah, H. Y., Zovoilis, A., Salinas-Riester, G., et al. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.293 · Cited by 150
A hippocampal Cdk5 pathway regulates extinction of contextual fear
Sananbenesi, F., Fischer, A., Wang, X., Schrick, C., Neve, R. L., Radulović, J., & Tsai, L. (2007) · Nature Neuroscience · doi:10.1038/nn1943 · Cited by 143
Self-citationGräff, J., Kahn, M., Samiei, A., Gao, J., Ota, K. T., Rei, D., & Tsai, L.-H. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.5657-12.2013 · Cited by 124
Self-citationLattal, K. M., & Wood, M. A. (2013) · Nature Neuroscience · doi:10.1038/nn.3302 · Cited by 121
The use of cognitive enhancers in animal models of fear extinction
Kaplan, G. B., & Moore, K. A. (2011) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2011.01.009 · Cited by 113
Costanzi, M., Cannas, S., Saraulli, D., Rossi‐Arnaud, C., & Cestari, V. (2011) · Learning & Memory · doi:10.1101/lm.2175811 · Cited by 111
Evidence‐based treatments for PTSD, new directions, and special challenges
Cukor, J., Olden, M., Lee, F. L. F., & Difede, J. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05793.x · Cited by 105
Spacing extinction trials alleviates renewal and spontaneous recovery
Urcelay, G. P., Wheeler, D. S., & Miller, R. R. (2009) · Learning & Behavior · doi:10.3758/lb.37.1.60 · Cited by 97
Harooni, H. E., Naghdi, N., Sepehri, H., & Rohani, A. H. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.02.011 · Cited by 81
Fujita, Y., Morinobu, S., Takei, S., Fuchikami, M., Matsumoto, T., Yamamoto, S., & Yamawaki, S. (2012) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2012.01.026 · Cited by 66
Itzhak, Y., Anderson, K. L., Kelley, J. B., & Petkov, M. (2012) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2012.03.005 · Cited by 61
Generation of High‐Titer Defective HSV‐1 Vectors
Lim, F., & Neve, R. L. (1999) · Current Protocols in Neuroscience · doi:10.1002/0471142301.ns0413s06 · Cited by 29
Self-citationType VI Adenylyl Cyclase Regulates Neurite Extension by Binding to Snapin and Snap25
Wu, C., Lin, J., Chien, C., Chang, W.-C., Lai, H., Chang, C., & Chern, Y. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.05593-11 · Cited by 21
Generation of High‐Titer Defective HSV‐1 Vectors
Neve, R. L., & Lim, F. (2013) · Current Protocols in Neuroscience · doi:10.1002/0471142301.ns0413s62 · Cited by 13
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Research works printed but not linked: 2
- Trapnell, 2013, Differential analysis of gene regulation at transcript resolution with RNA-seq, Nat. Biotechnol., 31, 46, 10.1038/nbt.2450 · DOI · Paper page
- Tsai, 2012, Use of CI-994 and dinaline for the treatment of memory/cognition and anxiety disorders, U.S. patent 8, 563
Cited by
Sorted by citations
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Lee, J. L. C., Nader, K., & Schiller, D. (2017) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2017.04.006 · Cited by 557
Singewald, N., Schmuckermair, C., Whittle, N., Holmes, A., & Ressler, K. J. (2015) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2014.12.004 · Cited by 390
“Extinction of recent fear memories (1 day after conditioning), using a memory update-consolidation paradigm, increases HDAC2 nitrosylation (Graff et al., 2014), which facilitates the dissociation of HDAC2 from chromatin (Nott et al.”
BackgroundInfluentialMaren, S., & Holmes, A. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2015.180 · Cited by 412
The Regulation of Transcription in Memory Consolidation
Alberini, C. M., & Kandel, E. R. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a021741 · Cited by 362
Sartori, S. B., & Singewald, N. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.107402 · Cited by 236
Metadata
- Authors
- Gräff, J., Joseph, N. F., Horn, M. E., Samiei, A., Meng, J., Seo, J., Rei, D., Bero, A. W., Phan, T. X., Wagner, F., Holson, E., Xu, J., Sun, J., Neve, R. L., Mach, R. H., Haggarty, S. J., & Tsai, L.-H.
- Affiliations
- Broad Institute (US)
- Howard Hughes Medical Institute (US)
- Massachusetts Institute of Technology (US)
- Washington University in St. Louis (US)
- Corresponding author
- Tsai, Li-Huei
- ORCID
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2014-01
- Volume
- 156
- Issue
- 1-2
- Pages
- 261-276
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC3986862
- OpenAlex
- W2021415039
- Cited by
- 357
- References
- 75
- Citations by year
- 2026: 13 · 2025: 22 · 2024: 21 · 2023: 20 · 2022: 28 · 2021: 27 · 2020: 25 · 2019: 22 · 2018: 45 · 2017: 32 · 2016: 34 · 2015: 32 · 2014: 36
- FWCI
- 22.87
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc-nd)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- Funders
- Howard Hughes Medical Institute
- National Institutes of Health
- National Institute on Aging
- National Institute on Drug Abuse (R01DA028301)
- National Institute of Neurological Disorders and Stroke (NS078839, R03NS090214, R01NS078839)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Keywords
- memory reconsolidation, HDAC2, S-nitrosylation, histone acetylation, hippocampal plasticity, histone deacetylase inhibitors, anxiety disorders, memory retrieval, synaptic plasticity
- MeSH terms
- Animals, Fear, Hippocampus, Male, Mice, Inbred C57BL, Neuronal Plasticity, Epigenesis, Genetic, Mice, Histone Deacetylase 2, Histone Deacetylase Inhibitors, Memory, Long-Term, Transcriptome
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