The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Ablation of PRDM16 and Beige Adipose Causes Metabolic Dysfunction and a Subcutaneous to Visceral Fat Switch
Open accessAbstract
SUMMARY A clear relationship exists between visceral obesity and type 2 diabetes, whereas subcutaneous obesity is comparatively benign. Here we show that adipocyte-specific deletion of the coregulatory protein PRDM16 caused minimal effects on classical brown fat but markedly inhibited beige adipocyte function in subcutaneous fat following cold exposure or β3-agonist treatment. These animals developed obesity on a high fat diet, with severe insulin resistance and hepatic steatosis. They also showed altered fat distribution with markedly increased subcutaneous adiposity. Subcutaneous adipose tissue in mutant mice acquired many key properties of visceral fat, including decreased thermogenic and increased inflammatory gene expression and increased macrophage accumulation. Transplantation of subcutaneous fat into mice with diet-induced obesity showed a loss of metabolic benefit when tissues were derived from PRDM16 mutant animals. These findings indicate that PRDM16 and beige adipocytes are required for the “browning” of white fat and the healthful effects of subcutaneous adipose tissue.
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Citations
Cites
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Nonalcoholic Fatty Liver Disease
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PRDM16 controls a brown fat/skeletal muscle switch
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Self-citationGeneral and abdominal adiposity and risk of death in Europe
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FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis
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“Cells from Adipo-PRDM16 KO mice also showed a blunted response to stimuli that induce browning, such as isoproterenol and FGF21 (Figures S2F ad S2G) (Fisher et al., 2012; Wu et al., 2013).”
BackgroundMice lacking mitochondrial uncoupling protein are cold-sensitive but not obese
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“Conversely, transgenic mice overexpressing adiponectin or mitoNEET in adipose tissue develop remarkable SubQ obesity, but remain metabolically healthy (Kim et al., 2007; Kusminski et al., 2012).”
BackgroundSelf-citationTranscriptional Control of Brown Fat Determination by PRDM16
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Cited by
Adipose tissue dysfunction as determinant of obesity-associated metabolic complications
Longo, M., Zatterale, F., Naderi, J., Parrillo, L., Formisano, P., Raciti, G. A., Beguinot, F., & Miele, C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20092358 · Cited by 1,575
Adipogenesis and metabolic health
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FTO Obesity Variant Circuitry and Adipocyte Browning in Humans
Claussnitzer, M., Dankel, S. N., Kim, K.-H., Quon, G., Meuleman, W., Haugen, C., Glunk, V., Sousa, I. S., Beaudry, J. L., Puviindran, V., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1502214 · Cited by 1,332
Adipose Tissue Remodeling: Its Role in Energy Metabolism and Metabolic Disorders
Choe, S. S., Huh, J. Y., Hwang, I. J., Kim, J. I., & Kim, J. B. (2016) · Frontiers in Endocrinology · doi:10.3389/fendo.2016.00030 · Cited by 1,206
Rao, R. R., Long, J. Z., White, J. P., Svensson, K. J., Lou, J., Lokurkar, I., Jedrychowski, M. P., Ruas, J. L., Wrann, C. D., Lo, J. C., et al. (2014) · Cell · doi:10.1016/j.cell.2014.03.065 · Cited by 973
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Metadata
- Authors
- Cohen, P., Levy, J. D., Zhang, Y., Frontini, A., Kolodin, D. P., Svensson, K. J., Lo, J. C., Zeng, X., Ye, L., Khandekar, M. J., Wu, J., Gunawardana, S. C., Banks, A. S., Camporez, J. P. G., Jurczak, M. J., Kajimura, S., Piston, D. W., Mathis, D., Cinti, S., Shulman, G. I., Seale, P., & Spiegelman, B. M.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2014-01
- Volume
- 156
- Issue
- 1-2
- Pages
- 304-316
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W1977782677
- Cited by
- 876
- References
- 16
- FWCI
- 53.65
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Cohen, P., Levy, J. D., Zhang, Y., Frontini, A., Kolodin, D. P., Svensson, K. J., Lo, J. C., Zeng, X., Ye, L., Khandekar, M. J., Wu, J., Gunawardana, S. C., Banks, A. S., Camporez, J. P. G., Jurczak, M. J., Kajimura, S., Piston, D. W., Mathis, D., Cinti, S., . . . Spiegelman, B. M. (2014). Ablation of PRDM16 and Beige Adipose Causes Metabolic Dysfunction and a Subcutaneous to Visceral Fat Switch. Cell. https://doi.org/10.1016/j.cell.2013.12.021
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