The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Self-Organizing Properties of Mouse Pluripotent Cells Initiate Morphogenesis upon Implantation
Open accessAbstract
Transformation of pluripotent epiblast cells into a cup-shaped epithelium as the mouse blastocyst implants is a poorly understood and yet key developmental step. Studies of morphogenesis in embryoid bodies led to the current belief that it is programmed cell death that shapes the epiblast. However, by following embryos developing in vivo and in vitro, we demonstrate that not cell death but a previously unknown morphogenetic event transforms the amorphous epiblast into a rosette of polarized cells. This transformation requires basal membrane-stimulated integrin signaling that coordinates polarization of epiblast cells and their apical constriction, a prerequisite for lumenogenesis. We show that basal membrane function can be substituted in vitro by extracellular matrix (ECM) proteins and that ES cells can be induced to form similar polarized rosettes that initiate lumenogenesis. Together, these findings lead to a completely revised model for peri-implantation morphogenesis in which ECM triggers the self-organization of the embryo's stem cells.
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Cites
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Molecular Cues to Implantation
Dey, S. K., Lim, H., Das, S. K., Reese, J., Paria, B. C., Daikoku, T., & Wang, H. (2004) · Endocrine Reviews · doi:10.1210/er.2003-0020 · Cited by 1,105
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From cells to organs: building polarized tissue
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Cdc42 - the centre of polarity
Etienne-Manneville, S. (2004) · Journal of Cell Science · doi:10.1242/jcs.01115 · Cited by 749
Requirement of FGF-4 for Postimplantation Mouse Development
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Cited by
van den Brink, S. C., Baillie-Johnson, P., Balayo, T., Hadjantonakis, A.-K., Nowotschin, S., Turner, D. A., & Martinez Arias, A. (2014) · Development · doi:10.1242/dev.113001 · Cited by 478
Formative pluripotency: the executive phase in a developmental continuum
Smith, A. (2017) · Development · doi:10.1242/dev.142679 · Cited by 474
Apical–basal polarity and the control of epithelial form and function
Buckley, C. E., & St Johnston, D. (2022) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-022-00465-y · Cited by 295
Neural tube morphogenesis in synthetic 3D microenvironments
Ranga, A., Girgin, M., Meinhardt, A., Eberle, D., Caiazzo, M., Tanaka, E. M., & Lutolf, M. P. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1603529113 · Cited by 221
BMP4 patterns Smad activity and generates stereotyped cell fate organization in spinal organoids
Duval, N., Vaslin, C., Barata, T. C., Frarma, Y., Contremoulins, V., Baudin, X., Nedelec, S., & Ribes, V. C. (2019) · Development · doi:10.1242/dev.175430 · Cited by 93
Metadata
- Authors
- Bedzhov, I., & Zernicka-Goetz, M.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2014-02
- Volume
- 156
- Issue
- 5
- Pages
- 1032-1044
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2044120077
- Cited by
- 448
- References
- 49
- FWCI
- 11.56
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
