The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Identification of a Circadian Output Circuit for Rest:Activity Rhythms in Drosophila
Open accessAbstract
SUMMARY Though much is known about the cellular and molecular components of the circadian clock, output pathways that couple clock cells to overt behaviors have not been identified. We conducted a screen for circadian-relevant neurons in the Drosophila brain, and report here that cells of the pars intercerebralis (PI), a functional homologue of the mammalian hypothalamus, comprise an important component of the circadian output pathway for rest:activity rhythms. GRASP analysis demonstrates that PI cells are connected to the clock through a polysynaptic circuit extending from pacemaker cells to PI neurons. Molecular profiling of relevant PI cells identified the corticotropin releasing factor (CRF) homologue, DH44, as a circadian output molecule that is specifically expressed by PI neurons and required for normal rest:activity rhythms. Notably, selective activation or ablation of just 6 DH44+ PI cells causes arrhythmicity. These findings delineate a circuit through which clock cells can modulate locomotor rhythms.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
A GAL4-Driver Line Resource for Drosophila Neurobiology
Jenett, A., Rubin, G. M., Ngo, T.-T. B., Shepherd, D., Murphy, C., Dionne, H., Pfeiffer, B. D., Cavallaro, A., Hall, D., Jeter, J., et al. (2012) · Cell Reports · doi:10.1016/j.celrep.2012.09.011 · Cited by 1,449
Motor control in a Drosophila taste circuit
Gordon, M. D., & Scott, K. (2009) · Neuron · doi:10.1016/j.neuron.2008.12.033 · Cited by 531
The adrenal peripheral clock: Glucocorticoid and the circadian timing system
Son, G. H., Chung, S., & Kim, K. (2011) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2011.07.003 · Cited by 136 · cited 1×
“In mammals, stress hormones, such as glucocorticoids, show diurnal cycles of secretion and serve as entrainment signals for peripheral clocks (Balsalobre et al., 2000; Son et al., 2011).”
Cited by
Circadian Rhythms and Sleep in Drosophila melanogaster
Dubowy, C., & Sehgal, A. (2017) · Genetics · doi:10.1534/genetics.115.185157 · Cited by 420
Self-citationRecent advances in neuropeptide signaling in Drosophila, from genes to physiology and behavior
Nässel, D. R., & Zandawala, M. (2019) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2019.02.003 · Cited by 355
Chemoconnectomics: Mapping Chemical Transmission in Drosophila
Deng, B., Li, Q., Liu, X., Cao, Y., Li, B., Qian, Y., Xu, R., Mao, R., Zhou, E., Zhang, W., et al. (2019) · Neuron · doi:10.1016/j.neuron.2019.01.045 · Cited by 340
Nässel, D. R. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041940 · Cited by 42
Sukumar, S. K., Antonydhason, V., Molander, L., Sandakly, J., Umapathy, G., Mendoza-Garcia, P., Masudi, T., Schlossser, A., Nässel, D. R., Wegener, C., et al. (2023) · doi:10.7554/elife.88985.1 · Cited by 1
Metadata
- Authors
- Cavanaugh, D. J., Geratowski, J. D., Wooltorton, J. R. A., Spaethling, J. M., Hector, C. E., Zheng, X., Johnson, E. C., Eberwine, J. H., & Sehgal, A.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2014-04
- Volume
- 157
- Issue
- 3
- Pages
- 689-701
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W1972140586
- Cited by
- 247
- References
- 3
- FWCI
- 8.93
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Identification of a Circadian Output Circuit for Rest:Activity Rhythms in Drosophila. https://app.cochat.ai/papers/10.1016/j.cell.2014.02.024
- The paper
- Cavanaugh, D. J., Geratowski, J. D., Wooltorton, J. R. A., Spaethling, J. M., Hector, C. E., Zheng, X., Johnson, E. C., Eberwine, J. H., & Sehgal, A. (2014). Identification of a Circadian Output Circuit for Rest:Activity Rhythms in Drosophila. Cell. https://doi.org/10.1016/j.cell.2014.02.024
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
