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Circadian Clock Control by SUMOylation of BMAL1

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Regulating gene transcription in response to cyclic AMP elevation

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Adrenal incidentaloma: a new cause of the metabolic syndrome?

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Dissecting the Functions of the Mammalian Clock Protein BMAL1 by Tissue-Specific Rescue in Mice

McDearmon, E. L., Patel, K., Ko, C. H., Walisser, J. A., Schook, A. C., Chong, J. L., Wilsbacher, L. D., Song, E. J., Hong, H., Bradfield, C. A., et al. (2006) · Science · doi:10.1126/science.1132430 · Cited by 321 · see citing works

Neurons and networks in daily rhythms

Herzog, E. D. (2007) · Nature reviews. Neuroscience · doi:10.1038/nrn2215 · Cited by 316 · see citing works

Adrenal peripheral clock controls the autonomous circadian rhythm of glucocorticoid by causing rhythmic steroid production

Son, G. H., Chung, S., Choe, H. K., Kim, H.-D., Baik, S. M., Lee, H., Lee, H., Choi, S., Sun, W., Kim, H., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0806962106 · Cited by 316 · see citing works

Effects of rotating shift work on biomarkers of metabolic syndrome and inflammation

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The Neuroendocrinology of Chronic Fatigue Syndrome

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Regulation of the steroidogenic acute regulatory protein gene expression: present and future perspectives

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Differential serotonergic innervation of the suprachiasmatic nucleus and the intergeniculate leaflet and its role in circadian rhythm modulation

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Acute Physical Stress Elevates Mouse Period1 mRNA Expression in Mouse Peripheral Tissues via a Glucocorticoid-responsive Element

Yamamoto, T., Nakahata, Y., Tanaka, M., Yoshida, M., Soma, H., Shinohara, K., Yasuda, A., Mamine, T., & Takumi, T. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m509600200 · Cited by 302 · see citing works

The Circadian Regulatory Proteins BMAL1 and Cryptochromes Are Substrates of Casein Kinase Iε

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A noncanonical E-box enhancer drives mouse Period2 circadian oscillations in vivo

Yoo, S. H., Ko, C. H., Lowrey, P. L., Buhr, E. D., Song, E.-J., Chang, S., Yoo, O. J., Yamazaki, S., Lee, C., & Takahashi, J. S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409763102 · Cited by 299 · see citing works

Deletion of the Mammalian Circadian Clock Gene BMAL1/Mop3 Alters Baseline Sleep Architecture and the Response to Sleep Deprivation

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Glucocorticoid action networks and complex psychiatric and/or somatic disorders

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Control of Intracellular Dynamics of Mammalian Period Proteins by Casein Kinase I ε (CKIε) and CKIδ in Cultured Cells

Akashi, M., Tsuchiya, Y., Yoshino, T., & Nishida, E. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.6.1693-1703.2002 · Cited by 292 · see citing works

The Circadian Clock Protein BMAL1 Is Necessary for Fertility and Proper Testosterone Production in Mice

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Glucocorticoids: exemplars of multi-tasking

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A Diurnal Rhythm of Stimulatory Input to the Hypothalamo–Pituitary–Adrenal System as Revealed by Timed Intrahypothalamic Administration of the Vasopressin V1Antagonist

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Adrenal glucocorticoids have a key role in circadian resynchronization in a mouse model of jet lag

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Properties, Entrainment, and Physiological Functions of Mammalian Peripheral Oscillators

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The role of mPer2 clock gene in glucocorticoid and feeding rhythms

Yang, S., Liu, A., Weidenhammer, A., Cooksey, R. C., McClain, D., Kim, M. K., Aguilera, G., Abel, E. D., & Chung, J. H. (2009) · Endocrinology · doi:10.1210/en.2008-0705 · Cited by 263 · see citing works

Glucocorticoid signaling synchronizes the liver circadian transcriptome

Reddy, A. B., Maywood, E. S., Karp, N. A., King, V. M., Inoue, Y., Gonzalez, F. J., Lilley, K. S., Kyriacou, C. P., & Hastings, M. H. (2007) · Hepatology · doi:10.1002/hep.21571 · Cited by 261 · see citing works

Transcriptional regulation of steroidogenic genes: StARD1, CYP11A1 and HSD3B

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Differential Rescue of Light- and Food-Entrainable Circadian Rhythms

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The central and basolateral nuclei of the amygdala exhibit opposite diurnal rhythms of expression of the clock protein Period2

Lamont, E. W., Robinson, B., Stewart, J., & Amir, S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500901102 · Cited by 256 · see citing works

Peripheral-type benzodiazepine receptor-mediated action of steroidogenic acute regulatory protein on cholesterol entry into Leydig cell mitochondria

Hauet, T., Yao, Z.-X., Bose, H. S., Wall, C. T., Han, Z., Li, W., Hales, D. B., Miller, W. L., Culty, M., & Papadopoulos, V. (2005) · Molecular Endocrinology · doi:10.1210/me.2004-0307 · Cited by 252 · see citing works

Effects of Suprachiasmatic Transplants on Circadian Rhythms of Neuroendocrine Function in Golden Hamsters**This work was supported by NIH Grants MH-44132, KO2-MH-00914, and F32-HD-07673. A preliminary report of this research was presented at the 23rd Annual Meeting of the Society for Neuroscience (Neurosci Abstr 19:236.17, 1993).

Meyer-Bernstein, E. L., Jetton, A. E., Matsumoto, S., Markuns, J. F., Lehman, M. N., & Bittman, E. L. (1999) · Endocrinology · doi:10.1210/endo.140.1.6428 · Cited by 252 · see citing works

Knockdown of Clock in the Ventral Tegmental Area Through RNA Interference Results in a Mixed State of Mania and Depression-Like Behavior

Mukherjee, S., Coque, L., Cao, J., Kumar, J., Chakravarty, S., Asaithamby, A., Graham, A., Gordon, E., Enwright, J. F., Dileone, R., et al. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.04.031 · Cited by 249 · see citing works

Adrenal splanchnic innervation contributes to the diurnal rhythm of plasma corticosterone in rats by modulating adrenal sensitivity to ACTH

Ulrich‐Lai, Y. M., Arnhold, M. M., & Engeland, W. C. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00042.2003 · Cited by 247 · see citing works

Endogenous Dopamine Regulates the Rhythm of Expression of the Clock Protein PER2 in the Rat Dorsal Striatum via Daily Activation of D₂Dopamine Receptors

Hood, S., Cassidy, P., Cossette, M.-P., Weigl, Y., Verwey, M., Robinson, B., Stewart, J., & Amir, S. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.2128-10.2010 · Cited by 246 · see citing works

The significance of glucocorticoid pulsatility

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Chronic Jet Lag Produces Cognitive Deficits

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Regulation of steroidogenesis and the steroidogenic acute regulatory protein by a member of the cAMP response-element binding protein family.

Manna, P. R., Dyson, M. T., Eubank, D. W., Clark, B. J., Lalli, E., Sassone-Corsi, P., Zeleznik, A. J., & Stocco, D. M. (2002) · Molecular Endocrinology · doi:10.1210/mend.16.1.0759 · Cited by 232 · see citing works

Transcriptional Profiling in the Adrenal Gland Reveals Circadian Regulation of Hormone Biosynthesis Genes and Nucleosome Assembly Genes

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Vasopressin-containing neurons of the suprachiasmatic nuclei inhibit corticosterone release

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Starvation: Early Signals, Sensors, and Sequelae1

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The Circadian ClockPeriod 2Gene Regulates Gamma Interferon Production of NK Cells in Host Response to Lipopolysaccharide-Induced Endotoxic Shock

Liu, J., Mankani, G., Shi, X., Meyer, M., Cunningham-Runddles, S., Ma, X., & Sun, Z. S. (2006) · Infection and Immunity · doi:10.1128/iai.00287-06 · Cited by 226 · see citing works

A Prospective Cohort Study of Shift Work and Risk of Ischemic Heart Disease in Japanese Male Workers

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Adrenal Sensitivity to Adrenocorticotropin Varies Diurnally*

KANEKO, M., Kaneko, K., Shinsako, J., & Dallman, M. F. (1981) · Endocrinology · doi:10.1210/endo-109-1-70 · Cited by 207 · see citing works

Expression of the Circadian Clock Gene Period2 in the Hippocampus: Possible Implications for Synaptic Plasticity and Learned Behaviour

Wang, L. M.-C., Dragich, J. M., Kudo, T., Odom, I. H., Welsh, D. K., O’Dell, T. J., & Colwell, C. S. (2009) · ASN NEURO · doi:10.1042/an20090020 · Cited by 201 · see citing works

Signaling mediated by the dopamine D2 receptor potentiates circadian regulation by CLOCK:BMAL1

Yujnovsky, I., Hirayama, J., Doi, M., Borrelli, E., & Sassone‐Corsi, P. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510691103 · Cited by 199 · see citing works

Systems Biology of Mammalian Circadian Clocks

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Late-night salivary cortisol as a screening test for cushing's syndrome

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Endogenous Regulation of Serotonin Release in the Hamster Suprachiasmatic Nucleus

Dudley, T. E., DiNardo, L. A., & Glass, J. D. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-13-05045.1998 · Cited by 193 · see citing works

Genome-wide Expression Analysis Reveals 100 Adrenal Gland-dependent Circadian Genes in the Mouse Liver

Oishi, K., Amagai, N., Shirai, H., Kadota, K., Ohkura, N., & Ishida, N. (2005) · DNA Research · doi:10.1093/dnares/dsi003 · Cited by 192 · see citing works

Effects of Destruction of the Suprachiasmatic Nuclei on the Circadian Rhythms in Plasma Corticosterone, Body Temperature, Feeding and Plasma Thyrotropin

Abe, K., Kroning, J., Greer, M. A., & CRITCHLOW, V. (2008) · Neuroendocrinology · doi:10.1159/000122913 · Cited by 189 · see citing works

Period 2 Mutation Accelerates ApcMin/+ Tumorigenesis

Wood, P. A., Yang, X., Taber, A., Oh, E.-Y., Ansell, C. M., Ayers, S. E., Al-Assaad, Z., Carnevale, K. A., Berger, F. G., Peña, M. M. O., et al. (2008) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-08-0196 · Cited by 181 · see citing works

Suprachiasmatic Regulation of Circadian Rhythms of Gene Expression in Hamster Peripheral Organs: Effects of Transplanting the Pacemaker

Guo, H., Brewer, J. M., Lehman, M. N., & Bittman, E. L. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.4676-05.2006 · Cited by 180 · see citing works

Glucocorticoids

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Neural Circuitry in the Regulation of Adrenal Corticosterone Rhythmicity

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A Circadian Rhythm in the Expression of PERIOD2 Protein Reveals a Novel SCN-Controlled Oscillator in the Oval Nucleus of the Bed Nucleus of the Stria Terminalis

Amir, S., Lamont, E. W., Robinson, B., & Stewart, J. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.4488-03.2004 · Cited by 175 · see citing works

Nycthemeral rhythm in adrenal responsiveness to ACTH

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Reproducibility of nighttime salivary cortisol and its use in the diagnosis of hypercortisolism compared with urinary free cortisol and overnight dexamethasone suppression test.

Viardot, A., Huber, P., Puder, J. J., Zulewski, H., Keller, U., & Müller, B. (2005) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jc.2004-2264 · Cited by 172 · see citing works

Circadian and Glucocorticoid Regulation of Rev-erbα Expression in Liver 1

Pineda‐Torra, I., Tsibulsky, V. P., Delaunay, F., Saladin, R., Laudet, V., Fruchart, J., Kosykh, V., & Staels, B. (2000) · Endocrinology · doi:10.1210/endo.141.10.7708 · Cited by 169 · see citing works

Daily Rhythm of Tryptophan Hydroxylase-2 Messenger Ribonucleic Acid within Raphe Neurons Is Induced by Corticoid Daily Surge and Modulated by Enhanced Locomotor Activity

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Dual Modification of BMAL1 by SUMO2/3 and Ubiquitin Promotes Circadian Activation of the CLOCK/BMAL1 Complex

Lee, J., Lee, Y., Lee, M.-J., Park, E., Kang, S. H., Chung, C. H., Lee, K. H., & Kim, K. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.00583-08 · Cited by 166 · see citing works

BMAL1 Shuttling Controls Transactivation and Degradation of the CLOCK/BMAL1 Heterodimer

Kwon, I., Lee, J., Chang, S. H., Jung, N. C., Lee, B. J., Son, G. H., Kim, K., & Lee, K. H. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00337-06 · Cited by 163 · see citing works

Role of the PKA‐Regulated Transcription Factor CREB in Development and Tumorigenesis of Endocrine Tissues

Rosenberg, D., Groussin, L., Jullian, E. H., Perlemoine, K., BERTAGNA, X. Y., & Bertherat, J. Y. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04327.x · Cited by 162 · see citing works

Internal desynchronization in a model of night-work by forced activity in rats

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Genetic Components of the Circadian Clock Regulate Thrombogenesis In Vivo

Westgate, E. J., Cheng, Y., Reilly, D. F., Price, T. S., Walisser, J. A., Bradfield, C. A., & FitzGerald, G. A. (2008) · Circulation · doi:10.1161/circulationaha.107.739227 · Cited by 155 · see citing works

Suprachiasmatic nucleus lesion increases corticosterone secretion

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Effect of shift work on the night-time secretory patterns of melatonin, prolactin, cortisol and testosterone

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Glucocorticoid rhythms control the rhythm of expression of the clock protein, Period2, in oval nucleus of the bed nucleus of the stria terminalis and central nucleus of the amygdala in rats

Segall, L. A., Perrin, J. S., Walker, C. D., Stewart, J., & Amir, S. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.03.037 · Cited by 141 · see citing works

Decrease of Endogenous Vasopressin Release Necessary for Expression of the Circadian Rise in Plasma Corticosterone: a Reverse Microdialysis Study

Kalsbeek, A., van der Vliet, J., & Buijs, R. M. (1996) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.1996.04597.x · Cited by 138 · see citing works

Inadequacies of glucocorticoid replacement and improvements by physiological circadian therapy

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Diurnal expression of functional and clock-related genes throughout the rat HPA axis: system-wide shifts in response to a restricted feeding schedule

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Circadian Clock Gene Regulation of Steroidogenic Acute Regulatory Protein Gene Expression in Preovulatory Ovarian Follicles

Nakao, N., Yasuo, S., Nishimura, A., Yamamura, T., Watanabe, T., Anraku, T., Okano, T., Fukada, Y., Sharp, P. J., Ebihara, S., et al. (2007) · Endocrinology · doi:10.1210/en.2007-0044 · Cited by 133 · see citing works

CK2α phosphorylates BMAL1 to regulate the mammalian clock

Tamaru, T., Hirayama, J., Isojima, Y., Nagai, K., Norioka, S., Takamatsu, K., & Sassone‐Corsi, P. (2009) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1578 · Cited by 131 · see citing works

Sleep Architecture and Sleep Apnea in Patients with Cushing's Disease

Shipley, J. E., SCHTEINGART, D. E., Tandon, R., & Starkman, M. N. (1992) · SLEEP · doi:10.1093/sleep/15.6.514 · Cited by 129 · see citing works

Quantitative Analyses of Circadian Gene Expression in Mammalian Cell Cultures

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Adrenal Innervation May Be an Extrapituitary Mechanism Able to Regulate Adrenocortical Rhythmicity in Rats*

Ottenweller, J. E., & MEIER, A. H. (1982) · Endocrinology · doi:10.1210/endo-111-4-1334 · Cited by 119 · see citing works

Coactivation of the CLOCK–BMAL1 complex by CBP mediates resetting of the circadian clock

Lee, Y., Lee, J., Kwon, I., Nakajima, Y., Ohmiya, Y., Son, G. H., Lee, K. H., & Kim, K. (2010) · Journal of Cell Science · doi:10.1242/jcs.070300 · Cited by 118 · see citing works

The Neuropsychiatric Profile of Addison’s Disease: Revisiting a Forgotten Phenomenon

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Dysregulation of Diurnal Rhythms of Serotonin 5-HT2Cand Corticosteroid Receptor Gene Expression in the Hippocampus with Food Restriction and Glucocorticoids

Holmes, M. C., French, K. L., & Seckl, J. R. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-11-04056.1997 · Cited by 110 · see citing works

Circadian metabolic patterns in cultured hamster adrenal glands

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Inhibition of Transcription Affects Synthesis of Steroidogenic Acute Regulatory Protein and Steroidogenesis in MA-10 Mouse Leydig Tumor Cells

Clark, B. J., Combs, R., Hales, K. H., Hales, D. B., & Stocco, D. M. (1997) · Endocrinology · doi:10.1210/endo.138.11.5535 · Cited by 105 · see citing works

Let there be “more” light: enhancement of light actions on the circadian system through non-photic pathways

Yannielli, P. C., & Harrington, M. E. (2004) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2004.06.001 · Cited by 105 · see citing works

Modulation of serotonin and corticosteroid receptor gene expression in the rat hippocampus with circadian rhythm and stress

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Impaired daily glucocorticoid rhythm in Per1 Brd mice

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Cyclic Adenosine 3′,5′-Monophosphate (cAMP) Enhances cAMP-Responsive Element Binding (CREB) Protein Phosphorylation and Phospho-CREB Interaction with the Mouse Steroidogenic Acute Regulatory Protein Gene Promoter

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Late-night salivary cortisol measurement in the diagnosis of Cushing’s syndrome

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Diurnal Variation in the Responsiveness of the Hypothalamic‐Pituitary‐Adrenal Axis of the Male Rat to Noise Stress

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Age-related changes of the adrenal secretory pattern: possible role in pathological brain aging

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Chronic exposure to environmentally relevant concentrations of carbamazepine interferes with anxiety response of adult female zebrafish through GABA /5-HT pathway and HPI axis

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Ambient fine particulate matter exposure disrupts circadian rhythm and oscillation of the HPA axis in a mouse model

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Cell Autonomous Circadian Systems and Their Relation to Inflammation

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Frank Beach Award Winner: The centrality of the hypothalamic-pituitary-adrenal axis in dealing with environmental change across temporal scales

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Circadian Clock Dysfunction and Psychiatric Disease: Could Fruit Flies have a Say?

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Chronic treatment with dexamethasone alters clock gene expression and melatonin synthesis in rat pineal gland at night

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EJE Prize 2023: genes on steroids—genomic control of hepatic metabolism by the glucocorticoid receptor

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An intricate relationship between circadian rhythm dysfunction and psychiatric diseases

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Chronic stress alters adrenal clock function in a sexually dimorphic manner

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Chronic Alcohol Consumption in Rats Leads to Desynchrony in Diurnal Rhythms and Molecular Clocks

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From Type-1 Diabetes HPA Axis to the Disease Complications

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Effects of Environmental Endocrine-Disrupting Chemicals on Female Reproductive Health

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Daily Profiles of Steroid Hormones and Their Metabolites Related to Food Intake

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Melatonin and corticosterone profiles under polar day in a seabird with sexually opposite activity-rhythms

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The sweet tooth of the circadian clock

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Potential for the development of light therapies in mild traumatic brain injury

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Loss of CREBRF Reduces Anxiety-like Behaviors and Circulating Glucocorticoids in Male and Female Mice

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Dietary supplementation with essence of chicken enhances daily oscillations in plasma glucocorticoid levels and behavioral adaptation to the phase-shifted environmental light–dark cycle in mice

Dilixiati, A., Koyanagi, S., Kusunose, N., Matsunaga, N., & Ohdo, S. (2017) · Journal of Pharmacological Sciences · doi:10.1016/j.jphs.2017.07.004 · Cited by 10 · see citing works

Effect of Cage Space on Behavior and Reproduction in Crl:CD(SD) and BN/Crl Laboratory Rats.

Gaskill, B. N., & Pritchett‐Corning, K. R. (2015) · PubMed Central · Cited by 10 · see citing works

Noncoding RNAs: Bridging Regulation of Circadian Rhythms and Inflammation

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Corticosteroids and circadian rhythms in the cardiovascular system

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Sleep and Circadian Rhythm Disruption in Psychosis

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Research progress on the central mechanism underlying regulation of visceral biological rhythm by per2 (Review)

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Pharmacological Modulators of Molecular Clock and their Therapeutic Potentials in Circadian Rhythm-Related Diseases

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Desipramine restores the alterations in circadian entrainment induced by prenatal exposure to glucocorticoids

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Irradiation with X-rays phase-advances the molecular clockwork in liver, adrenal gland and pancreas

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Alterations in methylation status of immune response genes promoters in cell-free DNA during a hemodialysis procedure

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The relationship between daily behavior, hormones, and a color dimorphism in a seabird under natural continuous light

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Identification of angiotensin II-responsive circadian clock gene expression in adrenal zona glomerulosa cells and human adrenocortical H295R cells

Otani, T., Miyake, T., Ota, T., Yarimizu, D., Nakagawa, Y., Murai, I., Okamura, H., Hasegawa, E., & Doi, M. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1525844 · Cited by 5 · see citing works

“Feeding the Rhythm”—Effects of Food and Nutrients on Daily Cortisol Secretion: From Molecular Mechanisms to Clinical Impact

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Circadian Rhythms in Conditioned Threat Extinction Reflect Time-of-Day Differences in Ventromedial Prefrontal Cortex Neural Processing

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Methylation Status of Immune Response Genes Promoters in Cell-Free DNA Differs in Hemodialyzed Patients with Diabetic Nephropathy According to the Intensity of Anemia Therapy

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Is the Circadian Rhythm Dysregulation a Core Pathogenetic Mechanism of Bipolar Disorder?

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Circadian Rhythm: Light-Dark Cycles

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Adrenal peripheral oscillator in generating the circadian glucocorticoid rhythm

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Adrenal peripheral clock controls the autonomous circadian rhythm of glucocorticoid by causing rhythmic steroid production

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Multimodal Regulation of Circadian Glucocorticoid Rhythm by Central and Adrenal Clocks

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Cooperative roles of the suprachiasmatic nucleus central clock and the adrenal clock in controlling circadian glucocorticoid rhythm

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Adrenal Clocks and the Role of Adrenal Hormones in the Regulation of Circadian Physiology

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