The DOI matches its Crossref record; 174 of the 174 references it cites were found in a registry or an index.
Remote Control of Gene Function by Local Translation
Open accessAbstract
The subcellular position of a protein is a key determinant of its function. Mounting evidence indicates that RNA localization, where specific mRNAs are transported subcellularly and subsequently translated in response to localized signals, is an evolutionarily conserved mechanism to control protein localization. On-site synthesis confers novel signaling properties to a protein and helps to maintain local proteome homeostasis. Local translation plays particularly important roles in distal neuronal compartments, and dysregulated RNA localization and translation cause defects in neuronal wiring and survival. Here, we discuss key findings in this area and possible implications of this adaptable and swift mechanism for spatial control of gene function.
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Spatially resolved, highly multiplexed RNA profiling in single cells
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Metadata
- Authors
- Jung, H., Gkogkas, C. G., Sonenberg, N., & Holt, C. E.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2014-03
- Volume
- 157
- Issue
- 1
- Pages
- 26-40
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2018404810
- Cited by
- 306
- References
- 174
- FWCI
- 14.24
- Type
- journal article
- Language
- en
- Open access
- hybrid
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- creativecommons.org/licenses/by/3.0/ (vor, 5 d)
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