The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Deconstructing the Peptide-MHC Specificity of T Cell Recognition
Open accessAbstract
Summary In order to survey a universe of MHC-presented peptide antigens whose numbers greatly exceed the diversity of the T cell repertoire, T cell receptors (TCRs) are thought to be cross-reactive. However, the nature and extent of TCR cross-reactivity has not been conclusively measured experimentally. We developed a system to identify MHC-presented peptide ligands by combining TCR selection of highly diverse yeast-displayed peptide-MHC libraries with deep sequencing. While we identified hundreds of peptides reactive with each of five different mouse and human TCRs, the selected peptides possessed TCR recognition motifs that bore a close resemblance to their known antigens. This structural conservation of the TCR interaction surface allowed us to exploit deep sequencing information to computationally identify activating microbial and self-ligands for human autoimmune TCRs. The mechanistic basis of TCR cross-reactivity described here enables effective surveillance of diverse self and foreign antigens, but without necessitating degenerate recognition of non-homologous peptides.
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Metadata
- Authors
- Birnbaum, M. E., Mendoza, J. L., Sethi, D. K., Dong, S., Glanville, J., Dobbins, J., Özkan, E., Davis, M. M., Wucherpfennig, K. W., & Garcia, K. C.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2014-05
- Volume
- 157
- Issue
- 5
- Pages
- 1073-1087
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W1979731533
- Cited by
- 556
- References
- 9
- FWCI
- 19.97
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Birnbaum, M. E., Mendoza, J. L., Sethi, D. K., Dong, S., Glanville, J., Dobbins, J., Özkan, E., Davis, M. M., Wucherpfennig, K. W., & Garcia, K. C. (2014). Deconstructing the Peptide-MHC Specificity of T Cell Recognition. Cell. https://doi.org/10.1016/j.cell.2014.03.047
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