The DOI matches its Crossref record; 135 of the 135 references it cites were found in a registry or an index.
Cancer Neoantigens
Open accessAbstract
Malignant transformation of cells depends on accumulation of DNA damage. Over the past years we have learned that the T cell–based immune system frequently responds to the neoantigens that arise as a consequence of this DNA damage. Furthermore, recognition of neoantigens appears an important driver of the clinical activity of both T cell checkpoint blockade and adoptive T cell therapy as cancer immunotherapies. Here we review the evidence for the relevance of cancer neoantigens in tumor control and the biological properties of these antigens. We discuss recent technological advances utilized to identify neoantigens, and the T cells that recognize them, in individual patients. Finally, we discuss strategies that can be employed to exploit cancer neoantigens in clinical interventions.
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Cites
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Cited by
A decade of immune-checkpoint inhibitors in cancer therapy
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Metadata
- Authors
- Schumacher, T. N., Scheper, W., & Kvistborg, P.
- Venue
- Annual Review of Immunology
- Publisher
- Annual Reviews
- Published
- 2019-04-26
- Volume
- 37
- Issue
- 1
- Pages
- 173-200
- ISSN
- 0732-0582 (ISSN-L)
- 1545-3278
- OpenAlex
- W4254055122
- Cited by
- 574
- References
- 135
- FWCI
- 6.56
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Schumacher, T. N., Scheper, W., & Kvistborg, P. (2019). Cancer Neoantigens. Annual Review of Immunology. https://doi.org/10.1146/annurev-immunol-042617-053402
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
