The DOI matches its Crossref record; 59 of the 60 references it cites were found in a registry or an index.
p53-Dependent Nestin Regulation Links Tumor Suppression to Cellular Plasticity in Liver Cancer
Open accessAbstract
The p53 tumor suppressor coordinates a series of antiproliferative responses that restrict the expansion of malignant cells, and as a consequence, p53 is lost or mutated in the majority of human cancers. Here, we show that p53 restricts expression of the stem and progenitor-cell-associated protein nestin in an Sp1/3 transcription-factor-dependent manner and that Nestin is required for tumor initiation in vivo. Moreover, loss of p53 facilitates dedifferentiation of mature hepatocytes into nestin-positive progenitor-like cells, which are poised to differentiate into hepatocellular carcinomas (HCCs) or cholangiocarcinomas (CCs) in response to lineage-specific mutations that target Wnt and Notch signaling, respectively. Many human HCCs and CCs show elevated nestin expression, which correlates with p53 loss of function and is associated with decreased patient survival. Therefore, transcriptional repression of Nestin by p53 restricts cellular plasticity and tumorigenesis in liver cancer.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“NF-Y77 and Sp178, 79 are the coactivators most commonly linked to p53-dependent gene downregulation through a mechanism of p53 interference.”
From Census and evaluation of p53 target genes (2017) · cites this paper as [79]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
A System for Stable Expression of Short Interfering RNAs in Mammalian Cells
Brummelkamp, T. R., Bernards, R., & Agami, R. (2002) · Science · doi:10.1126/science.1068999 · Cited by 4,295
Blinded by the Light: The Growing Complexity of p53
Vousden, K. H., & Prives, C. (2009) · Cell · doi:10.1016/j.cell.2009.04.037 · Cited by 3,163
Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
Xue, W., Zender, L., Miething, C., Dickins, R. A., Hernando, E., Krizhanovsky, V., Cordon-Cardo, C., & Lowe, S. W. (2007) · Nature · doi:10.1038/nature05529 · Cited by 2,473
Self-citationElucidation of a universal size-control mechanism in Drosophila and mammals
Dong, J., Feldmann, G., Huang, J., Wu, S., Zhang, N., Comerford, S. A., Gayyed, M. F., Anders, R. A., Maitra, A., & Pan, D. (2007) · Cell · doi:10.1016/j.cell.2007.07.019 · Cited by 2,370
A restricted cell population propagates glioblastoma growth after chemotherapy
Chen, J., Li, Y., Yu, T.-S., McKay, R. M., Burns, D. K., Kernie, S. G., & Parada, L. F. (2012) · Nature · doi:10.1038/nature11287 · Cited by 2,354
Vousden, K. H., & Lane, D. P. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2147 · Cited by 2,351
Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways
Grimm, D., Streetz, K. L., Jopling, C. L., Storm, T. A., Pandey, K., Davis, C. R., Marion, P., Salazar, F., & Kay, M. A. (2006) · Nature · doi:10.1038/nature04791 · Cited by 1,677
Suppression of induced pluripotent stem cell generation by the p53–p21 pathway
Hong, H., Takahashi, K., Ichisaka, T., Aoi, T., Kanagawa, O., Nakagawa, M., Okita, K., & Yamanaka, S. (2009) · Nature · doi:10.1038/nature08235 · Cited by 1,301
Bond, G. L., Hu, W., Bond, E. E., Robins, H., Lutzker, S. G., Arva, N. C., Bargonetti, J., Bartel, F., Taubert, H., Wuerl, P., et al. (2004) · Cell · doi:10.1016/j.cell.2004.11.022 · Cited by 1,265
Linking the p53 tumour suppressor pathway to somatic cell reprogramming
Kawamura, T., Suzuki, J., Wang, Y. V., Menendez, S., Morera, L. B., Raya, A., Wahl, G. M., & Belmonte, J. C. I. (2009) · Nature · doi:10.1038/nature08311 · Cited by 1,115
Cited by
Sorted by citations
Kastenhuber, E. R., & Lowe, S. W. (2017) · Cell · doi:10.1016/j.cell.2017.08.028 · Cited by 1,906
Self-citationLiver Cancer Cell of Origin, Molecular Class, and Effects on Patient Prognosis
Sia, D., Villanueva, A., Friedman, S. L., & Llovet, J. M. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.11.048 · Cited by 1,181
P53 in survival, death and metabolic health: a lifeguard with a licence to kill.
Kruiswijk, F., Labuschagne, C. F., & Vousden, K. H. (2015) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm4007 · Cited by 1,080
Mu, P., Zhang, Z., Benelli, M., Karthaus, W. R., Hoover, E., Chen, C.-C., Wongvipat, J., Ku, S., Gao, D., Cao, Z., et al. (2017) · Science · doi:10.1126/science.aah4307 · Cited by 1,089
Self-citationCensus and evaluation of p53 target genes
Fischer, M. (2017) · Oncogene · doi:10.1038/onc.2016.502 · Cited by 971
The senescence-associated secretory phenotype induces cellular plasticity and tissue regeneration.
Ritschka, B., Storer, M., Mas, A., Heinzmann, F., Ortells, M. C., Morton, J. P., Sansom, O. J., Zender, L., & Keyes, W. M. (2017) · Genes & Development · doi:10.1101/gad.290635.116 · Cited by 650
Self-citationThe immunological and metabolic landscape in primary and metastatic liver cancer
Li, X., Ramadori, P., Pfister, D. R., Seehawer, M., Zender, L., & Heikenwälder, M. F. (2021) · Nature reviews. Cancer · doi:10.1038/s41568-021-00383-9 · Cited by 639
Self-citationUnderstanding the complexity of p53 in a new era of tumor suppression
Liu, Y., Su, Z., Tavana, O., & Gu, W. J. (2024) · Cancer Cell · doi:10.1016/j.ccell.2024.04.009 · Cited by 538
p53 Represses the Mevalonate Pathway to Mediate Tumor Suppression
Moon, S.-H., Huang, C., Houlihan, S. L., Regunath, K., Freed-Pastor, W. A., Morris, J. P., Tschaharganeh, D. F., Kastenhuber, E. R., Barsotti, A. M., Culp‐Hill, R., et al. (2018) · Cell · doi:10.1016/j.cell.2018.11.011 · Cited by 447
Self-citationTumor initiation and early tumorigenesis: molecular mechanisms and interventional targets
Zhang, S., Xiao, X., Yi, Y., Wang, X., Zhu, L., Shen, Y., Lin, D., & Wu, C. H. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01848-7 · Cited by 463
Functional and genetic deconstruction of the cellular origin in liver cancer
Marquardt, J. U., Andersen, J. B., & Thorgeirsson, S. S. (2015) · Nature reviews. Cancer · doi:10.1038/nrc4017 · Cited by 306
Self-citationXue, R., Chen, L., Zhang, C., Fujita, M., Li, R., Yan, S.-M., Ong, C. K., Liao, X., Gao, Q., Sasagawa, S., et al. (2019) · Cancer Cell · doi:10.1016/j.ccell.2019.04.007 · Cited by 296
Bollard, J., Miguela, V., de Galarreta, M. R., Venkatesh, A., Bian, C. B., Roberto, M. P., Tovar, V., Sia, D., Molina-Sánchez, P., Nguyen, C. B., et al. (2016) · Gut · doi:10.1136/gutjnl-2016-312268 · Cited by 291
A Review of Gut Microbiota‐Derived Metabolites in Tumor Progression and Cancer Therapy
Yang, Q., Wang, B., Zheng, Q., Li, H., Meng, X., Zhou, F., & Zhang, L. (2023) · Advanced Science · doi:10.1002/advs.202207366 · Cited by 259
MDM2–p53 Pathway in Hepatocellular Carcinoma
Meng, X., Franklin, D. A., Dong, J., & Zhang, Y. (2014) · Cancer Research · doi:10.1158/0008-5472.can-14-1446 · Cited by 216
Ling, S., Shan, Q., Zhan, Q., Ye, Q., Liu, P., Xu, S., He, X., Ma, J., Xiang, J., Jiang, G., et al. (2019) · Gut · doi:10.1136/gutjnl-2019-319616 · Cited by 215
Li, F., Huangyang, P., Burrows, M., Guo, K., Riscal, R., Godfrey, J. T., Lee, K. E., Lin, N., Lee, P., Blair, I. A., et al. (2020) · Nature Cell Biology · doi:10.1038/s41556-020-0511-2 · Cited by 216
Combined hepatocellular-cholangiocarcinoma: An update
Bèaufrere, A., Caldéraro, J., & Paradis, V. (2021) · Journal of Hepatology · doi:10.1016/j.jhep.2021.01.035 · Cited by 205
Cancer cell plasticity: Impact on tumor progression and therapy response
da Silva-Diz, V., Lorenzo-Sanz, L., Bernat‐Peguera, A., Lopez-Cerda, M., & Muñoz, P. (2018) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2018.08.009 · Cited by 217
CDK9-mediated transcription elongation is required for MYC addiction in hepatocellular carcinomaPreprint
Huang, C., Lujambio, A., Zuber, J. A., Tschaharganeh, D. F., Doran, M. G., Evans, M. J., Kitzing, T. M., Zhu, N., de Stanchina, E., Sawyers, C. L., et al. (2014) · Genes & Development · doi:10.1101/gad.244368.114 · Cited by 204
Self-citationYuan, D., Huang, S. H., Berger, E., Liu, L., Groß, N., Heinzmann, F., Ringelhan, M., Connor, T. O., Stadler, M., Meister, M. T., et al. (2017) · Cancer Cell · doi:10.1016/j.ccell.2017.05.006 · Cited by 203
Self-citationSharma, P., Alsharif, S., Fallatah, A., & Chung, B. M. (2019) · Cells · doi:10.3390/cells8050497 · Cited by 180
Cancer Stem Cell Plasticity – A Deadly Deal
Thankamony, A. P., Saxena, K., Murali, R., Jolly, M. K., & Nair, R. (2020) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2020.00079 · Cited by 178
Chiu, D. K., Yuen, V. W., Cheu, J. W., Wei, L. L., Ting, V., Fehlings, M., Sumatoh, H., Nardin, A., Newell, E. W., Ng, I. O., et al. (2020) · Gastroenterology · doi:10.1053/j.gastro.2020.03.074 · Cited by 171
Stretching the limits: from homeostasis to stem cell plasticity in wound healing and cancer
Ge, Y., & Fuchs, E. V. (2018) · Nature Reviews Genetics · doi:10.1038/nrg.2018.9 · Cited by 172
Cytoskeletal Remodeling in Cancer
Aseervatham, J. (2020) · Biology · doi:10.3390/biology9110385 · Cited by 175
Kastenhuber, E. R., Lalazar, G., Houlihan, S. L., Tschaharganeh, D. F., Baslan, T., Chen, C.-C., Requena, D., Tian, S., Bosbach, B., Wilkinson, J. E., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1716483114 · Cited by 163
Self-citationLiver Cancer: Molecular Characterization, Clonal Evolution and Cancer Stem Cells
Castelli, G., Pelosi, E., & Testa, U. (2017) · Cancers · doi:10.3390/cancers9090127 · Cited by 162
Germline loss of PKM2 promotes metabolic distress and hepatocellular carcinomaPreprint
Dayton, T. L., Gocheva, V., Miller, K. M., Israelsen, W. J., Bhutkar, A. J., Clish, C. B., Davidson, S. M., Luengo, A., Bronson, R. T., Jacks, T., et al. (2016) · Genes & Development · doi:10.1101/gad.278549.116 · Cited by 154
The Oncogenic Action of NRF2 Depends on De-glycation by Fructosamine-3-Kinase
Sanghvi, V. R., Leibold, J., Mina, M., Mohan, P., Berishaj, M., Li, Z., Miele, M. M., Lailler, N., Zhao, C., de Stanchina, E., et al. (2019) · Cell · doi:10.1016/j.cell.2019.07.031 · Cited by 155
Self-citationNew Insights into the Crossroads between EMT and Stemness in the Context of Cancer
Fabregat, I., Malfettone, A., & Soukupová, J. (2016) · Journal of Clinical Medicine · doi:10.3390/jcm5030037 · Cited by 147
Nestin regulates cellular redox homeostasis in lung cancer through the Keap1–Nrf2 feedback loop
Wang, J., Lu, Q., Cai, J., Wang, Y., Lai, X., Qiu, Y., Huang, Y., Ke, Q., Zhang, Y., Guan, Y., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-12925-9 · Cited by 130
Are there multiple cells of origin of Merkel cell carcinoma?
Sunshine, J. C., Jahchan, N. S., Sage, J., & Choi, J. (2018) · Oncogene · doi:10.1038/s41388-017-0073-3 · Cited by 136
The Fountain of Youth by Targeting Senescent Cells?
de Keizer, P. L. J. (2017) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2016.11.006 · Cited by 127
Hu, J., Che, L., Li, L., Pilo, M. G., Cigliano, A., Ribback, S., Li, X., Latte, G., Mela, M., Evert, M., et al. (2016) · Scientific Reports · doi:10.1038/srep20484 · Cited by 123
Self-citationp53: emerging roles in stem cells, development and beyond
Jain, A. K., & Barton, M. C. (2018) · Development · doi:10.1242/dev.158360 · Cited by 130
Lunyak, V. V., Amaro-Ortiz, A., & Gaur, M. (2017) · Frontiers in Genetics · doi:10.3389/fgene.2017.00220 · Cited by 119
Kras and Tp53 Mutations Cause Cholangiocyte- and Hepatocyte-Derived Cholangiocarcinoma
Hill, M. A., Alexander, W. B., Guo, B., Kato, Y., Patra, K. C., O’Dell, M. R., McCall, M. N., Whitney‐Miller, C. L., Bardeesy, N. M., & Hezel, A. F. (2018) · Cancer Research · doi:10.1158/0008-5472.can-17-1123 · Cited by 112
Zmat3 Is a Key Splicing Regulator in the p53 Tumor Suppression Program
Bieging-Rolett, K. T., Kaiser, A. M., Morgens, D. W., Boutelle, A. M., Seoane, J. A., Nostrand, E. L. V., Zhu, C., Houlihan, S. L., Mello, S. S., Yee, B. A., et al. (2020) · Molecular Cell · doi:10.1016/j.molcel.2020.10.022 · Cited by 114
Self-citationCancer stem cells in hepatocellular carcinoma: an overview and promising therapeutic strategies
Wang, N., Wang, S., Li, M., Hu, B., Liu, L., Yang, S., Yang, S., Gong, Z., Lai, P. B. S., & Chen, G. G. (2018) · Therapeutic Advances in Medical Oncology · doi:10.1177/1758835918816287 · Cited by 116
Lineage Plasticity in Cancer Progression and Treatment
Magnen, C. L., Shen, M. M., & Abate-Shen, C. T. (2017) · Annual Review of Cancer Biology · doi:10.1146/annurev-cancerbio-030617-050224 · Cited by 105
GPD1 Specifically Marks Dormant Glioma Stem Cells with a Distinct Metabolic Profile
Rusu, P., Shao, C., Neuerburg, A., Acikgöz, A. A., Wu, Y., Zou, P., Phapale, P., Shankar, T. S., Döring, K., Dettling, S., et al. (2019) · Cell Stem Cell · doi:10.1016/j.stem.2019.06.004 · Cited by 108
Self-citationAnti-tumor effects and cellular mechanisms of resveratrol
Han, G., Xia, J., Gao, J., Inagaki, Y., Tang, W., & Kokudo, N. (2015) · Drug Discoveries & Therapeutics · doi:10.5582/ddt.2015.01007 · Cited by 108
p53 Functions in Adipose Tissue Metabolism and Homeostasis
Krstić, J., Reinisch, I., Schupp, M., Schulz, T. J., & Prokesch, A. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19092622 · Cited by 110
p53 governs an AT1 differentiation programme in lung cancer suppression
Kaiser, A. M., Gatto, A., Hanson, K. J., Zhao, R. L., Raj, N., Ozawa, M. G., Seoane, J. A., Bieging-Rolett, K. T., Wang, M., Li, I., et al. (2023) · Nature · doi:10.1038/s41586-023-06253-8 · Cited by 100
Transforming Growth Factor-β Promotes Liver Tumorigenesis in Mice via Up-regulation of Snail
Moon, H., Ju, H.-L., Chung, S. I., Cho, K. J., Eun, J. W., Nam, S. W., Han, K., Calvisi, D. F., & Ro, S. W. (2017) · Gastroenterology · doi:10.1053/j.gastro.2017.07.014 · Cited by 93
Self-citationCytokine-armed dendritic cell progenitors for antigen-agnostic cancer immunotherapy
Ghasemi, A., Martínez-Usatorre, A., Li, L., Hicham, M., Guichard, A., Marcone, R., Fournier, N., Torchia, B., Bedoya, D. M., Davanture, S., et al. (2023) · Nature Cancer · doi:10.1038/s43018-023-00668-y · Cited by 96
Méndez‐Lucas, A., Li, X., Hu, J., Che, L., Song, X., Jia, J., Wang, J., Xie, C., Driscoll, P. C., Tschaharganeh, D. F., et al. (2017) · Cancer Research · doi:10.1158/0008-5472.can-17-0498 · Cited by 90
Self-citationSantoro, A., Vlachou, T., Luzi, L., Melloni, G. E. M., Mazzarella, L., D’Elia, E., Xieraili, A., Pasi, C. E., Reavie, L. B., Bonetti, P., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2018.12.071 · Cited by 88
Lineage Reversion Drives WNT Independence in Intestinal Cancer
Han, T., Goswami, S., Hu, Y., Tang, F., Zafra, M. P., Murphy, C. J., Cao, Z., Poirier, J. T., Khurana, E., Elemento, O., et al. (2020) · Cancer Discovery · doi:10.1158/2159-8290.cd-19-1536 · Cited by 81
Self-citationLiver Inflammation and Hepatobiliary Cancers
Leone, V., Ali, A., Weber, A., Tschaharganeh, D. F., & Heikenwälder, M. F. (2021) · Trends in cancer · doi:10.1016/j.trecan.2021.01.012 · Cited by 88
Self-citationTargeting Nestin+ hepatic stellate cells ameliorates liver fibrosis by facilitating TβRI degradation
Chen, H., Cai, J., Wang, J., Qiu, Y., Jiang, C., Wang, Y., Wang, Y., Yi, C., Lv, G., Pan, L., et al. (2020) · Journal of Hepatology · doi:10.1016/j.jhep.2020.11.016 · Cited by 82
Cellular and molecular mechanisms of plasticity in cancer
Torborg, S. R., Li, Z., Chan, J. E., & Tammela, T. (2022) · Trends in cancer · doi:10.1016/j.trecan.2022.04.007 · Cited by 83
Cancer Stem cells and their cellular origins in primary liver and biliary tract cancers
Oikawa, T. (2016) · Hepatology · doi:10.1002/hep.28485 · Cited by 84
Cell of origin in biliary tract cancers and clinical implications
Moeini, A., Haber, P. K., & Sia, D. (2021) · JHEP Reports · doi:10.1016/j.jhepr.2021.100226 · Cited by 85
Buczak, K., Ori, A., Kirkpatrick, J. M., Hölzer, K., Dauch, D., Roessler, S. K., Endris, V., Lasitschka, F., Parca, L., Schmidt, A., et al. (2018) · Molecular & Cellular Proteomics · doi:10.1074/mcp.ra117.000189 · Cited by 81
Self-citationCancer Stemness: p53 at the Wheel
Ghatak, D., Ghosh, D. D., & Roychoudhury, S. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2020.604124 · Cited by 75
Cancer stem cells in human gastrointestinal cancer
Taniguchi, H., Moriya, C., Igarashi, H., Saitoh, A., Yamamoto, H., Adachi, Y., & Imai, K. (2016) · Cancer Science · doi:10.1111/cas.13069 · Cited by 76
MiR-183-5p is required for non-small cell lung cancer progression by repressing PTEN
Wang, H., Ma, Z., Liu, X., Zhang, C., Hu, Y., Lei, D., Qi, P., Wang, J., Lu, S., & Li, Y. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.12.115 · Cited by 74
Potent effect of the MDM2 inhibitor AMG232 on suppression of glioblastoma stem cells
Her, N.-G., Oh, J.-W., Oh, Y. J., Han, S., Cho, H. J., Lee, Y., Ryu, G. H., & Nam, D.-H. (2018) · Cell Death & Disease · doi:10.1038/s41419-018-0825-1 · Cited by 68
Liver p53 is stabilized upon starvation and required for amino acid catabolism and gluconeogenesis
Prokesch, A., Graef, F. A., Madl, T., Kahlhofer, J., Heidenreich, S., Schumann, A., Moyschewitz, E., Pristoynik, P., Blaschitz, A., Knauer, M., et al. (2016) · The FASEB Journal · doi:10.1096/fj.201600845r · Cited by 71
Multiplexed orthogonal genome editing and transcriptional activation by Cas12a
Breinig, M., Schweitzer, A. Y., Herianto, A. M., Revia, S., Schaefer, L. M., Wendler, L., Galvez, A. C., & Tschaharganeh, D. F. (2018) · Nature Methods · doi:10.1038/s41592-018-0262-1 · Cited by 68
Self-citationCell death pathologies: targeting death pathways and the immune system for cancer therapy
Pentimalli, F., Grelli, S., Daniele, N. D., Melino, G., & Amelio, I. (2018) · Genes and Immunity · doi:10.1038/s41435-018-0052-x · Cited by 69
Zhu, C., Ho, Y.-J., Salomao, M. A., Dapito, D. H., Bartolomé, A., Schwabe, R. F., Lee, J., Lowe, S. W., & Pajvani, U. B. (2020) · Journal of Hepatology · doi:10.1016/j.jhep.2020.09.032 · Cited by 73
Self-citationSasaki, M., Sato, Y., & Nakanuma, Y. (2017) · Histopathology · doi:10.1111/his.13084 · Cited by 64
Li, X., Tao, J., Cigliano, A., Sini, M., Caldéraro, J., Azoulay, D., Wang, C., Liu, Y., Jiang, L., Evert, K., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.3546 · Cited by 65
Self-citationMolecular signatures in hepatocellular carcinoma: A step toward rationally designed cancer therapy
Erstad, D. J., Fuchs, B. C., & Tanabe, K. K. (2018) · Cancer · doi:10.1002/cncr.31257 · Cited by 64
p53 as a Dichotomous Regulator of Liver Disease: The Dose Makes the Medicine
Krstić, J., Galhuber, M., Schulz, T. J., Schupp, M., & Prokesch, A. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19030921 · Cited by 65
Gu, J., Mao, W., Ren, W., Xu, F., Zhu, Q., Lu, C., Lin, Z., Zhang, Z., Chu, Y., Liu, R., et al. (2018) · Cancer Letters · doi:10.1016/j.canlet.2018.11.029 · Cited by 62
Mutant p53 Drives Cancer Metastasis via RCP-Mediated Hsp90α Secretion
Zhang, S., Wang, C., Ma, B., Xu, M., Xu, S., Liu, J., Tian, Y., Fu, Y., & Luo, Y. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107879 · Cited by 61
The Cancer Stem Cell in Hepatocellular Carcinoma
Schulte, L.-A., López-Gil, J. C., Sáinz, B., & Hermann, P. C. (2020) · Cancers · doi:10.3390/cancers12030684 · Cited by 59
New insights into the pathophysiology and clinical care of rare primary liver cancers
Gigante, E., Paradis, V., Ronot, M., Cauchy, F., Soubrane, O., Ganne‐Carrié, N., & Nault, J. (2020) · JHEP Reports · doi:10.1016/j.jhepr.2020.100174 · Cited by 58
Sirica, A. E., Strazzabosco, M., & Cadamuro, M. (2020) · Advances in cancer research · doi:10.1016/bs.acr.2020.10.005 · Cited by 59
Multifaceted role for p53 in pancreatic cancer suppression
Mello, S. S., Flowers, B. M., Mazur, P. K., Lee, J. J., Müller, F., Denny, S. K., Ferreira, S., Hanson, K., Kim, S. K., Greenleaf, W. J., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2211937120 · Cited by 55
Wang, T., Xu, C., Zhang, Z., Wu, H. J., Li, X., Zhang, Y., Deng, N., Dang, N., Tang, G., Yang, X., et al. (2022) · Hepatology · doi:10.1002/hep.32483 · Cited by 52
Phenotypic plasticity during metastatic colonization
Jehanno, C., Vulin, M., Richina, V., Richina, F., & Bentires‐Alj, M. (2022) · Trends in Cell Biology · doi:10.1016/j.tcb.2022.03.007 · Cited by 60
Tsujikawa, H., Masugi, Y., Yamazaki, K., Itano, O., Kitagawa, Y., & Sakamoto, M. (2015) · Human Pathology · doi:10.1016/j.humpath.2015.10.014 · Cited by 56
Combined Hepatocellular-Cholangiocarcinoma: Biology, Diagnosis, and Management
Ye, L., Schneider, J. S., Khaled, N. B., Schirmacher, P., Seifert, C., Frey, L., He, Y., Geier, A., Toni, E. N. D., Zhang, C., et al. (2023) · Liver Cancer · doi:10.1159/000530700 · Cited by 55
D’Abramo, M., Bešker, N., Desideri, A., Levine, A. J., Melino, G., & Chillemi, G. (2015) · Oncogene · doi:10.1038/onc.2015.388 · Cited by 53
Hyperpolyploidization of hepatocyte initiates preneoplastic lesion formation in the liver
Lin, H., Huang, Y., Fustin, J., Doi, M., Chen, H., Lai, H., Lin, S., Lee, Y.-L., King, P.-C., Hou, H.-S., et al. (2021) · Nature Communications · doi:10.1038/s41467-020-20572-8 · Cited by 53
Clonal Evolution and Epithelial Plasticity in the Emergence of AR-Independent Prostate Carcinoma
Laudato, S., Aparicio, A. M., & Giancotti, F. G. (2019) · Trends in cancer · doi:10.1016/j.trecan.2019.05.008 · Cited by 50
Hepatitis B Virus-Associated Hepatocellular Carcinoma and Hepatic Cancer Stem Cells
Mani, S. K. K., & ANDRISANI, O. M. (2018) · Genes · doi:10.3390/genes9030137 · Cited by 51
An Update on MDMX and Dual MDM2/X Inhibitors
Espadinha, M., Barcherini, V., Lopes, E. A., & Santos, M. M. M. (2018) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026618666180604080119 · Cited by 49
Histone H3K27 demethylase KDM6A is an epigenetic gatekeeper of mTORC1 signalling in cancer
Revia, S., Seretny, A., Wendler, L., Banito, A., Eckert, C., Breuer, K., Mayakonda, A., Lutsik, P., Evert, M., Ribback, S., et al. (2021) · Gut · doi:10.1136/gutjnl-2021-325405 · Cited by 52
Self-citationEpigenome Remodeling in Cholangiocarcinoma
O’Rourke, C. J., Lafuente-Barquero, J. F., & Andersen, J. B. (2019) · Trends in cancer · doi:10.1016/j.trecan.2019.05.002 · Cited by 48
Self-citationCriteria for preclinical models of cholangiocarcinoma: scientific and medical relevance
Calvisi, D. F., Boulter, L., Vaquero, J., Saborowski, A. L., Fabris, L., Rodrigues, P. M., Coulouarn, C., Castro, R. E., Segatto, O., Raggi, C., et al. (2023) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-022-00739-y · Cited by 51
Self-citationNOTCH target gene HES5 mediates oncogenic and tumor suppressive functions in hepatocarcinogenesis
Luiken, S., Fraas, A., Bieg, M., Sugiyanto, R. N., Goeppert, B. F., Singer, S., Ploeger, C., Warsow, G., Marquardt, J. U., Sticht, C., et al. (2020) · Oncogene · doi:10.1038/s41388-020-1198-3 · Cited by 49
Self-citationZhang, Y., Zeng, S., Ma, J., Deng, G., Qu, Y., Guo, C., & Shen, H. (2016) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-016-0387-y · Cited by 46
Genomic and transcriptomic profiling of hepatoid adenocarcinoma of the stomach
Liu, Z.-Y., Wang, A.-Q., Pu, Y.-Y., Li, Z.-W., Xue, R.-D., Zhang, C., Xiang, X., E, J., Bu, Z., Bai, F., et al. (2021) · Oncogene · doi:10.1038/s41388-021-01976-2 · Cited by 41
p53 suppresses muscle differentiation at the myogenin step in response to genotoxic stress
Yang, Z., Brož, D. K., Noderer, W. L., Ferreira, J. P., Overton, K. W., Spencer, S. L., Meyer, T., Tapscott, S. J., Attardi, L. D., & Wang, C. L. (2014) · Cell Death and Differentiation · doi:10.1038/cdd.2014.189 · Cited by 48
Wu, J., Lü, M., Li, Y., Shang, Y.-K., Wang, S.-J., Meng, Y., Wang, Z., Zs, L., Chen, H., Chen, Z.-N., et al. (2016) · Oncogene · doi:10.1038/onc.2016.89 · Cited by 44
Molecular and radiopathologic spectrum between HCC and intrahepatic cholangiocarcinoma
Jeon, Y., Kwon, S. M., Rhee, H., Yoo, J. E., Chung, T., Woo, H. G., & Park, Y. N. (2022) · Hepatology · doi:10.1002/hep.32397 · Cited by 47
Koui, Y., Himeno, M., Mori, Y., Nakano, Y., Saijou, E., Tanimizu, N., Kamiya, Y., Anzai, H., Maeda, N., Wang, L. L., et al. (2021) · Stem Cell Reports · doi:10.1016/j.stemcr.2021.11.002 · Cited by 46
Sirtuin1-p53: A potential axis for cancer therapy
Yin, J., Lu, X.-T., Hou, M.-L., Cao, T., & Tian, Z. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115543 · Cited by 44
Turning Hepatic Cancer Stem Cells Inside Out – A Deeper Understanding through Multiple Perspectives
Chan, L.-H., Luk, S. T.-C., & Ma, S. (2015) · Molecules and Cells · doi:10.14348/molcells.2015.2356 · Cited by 42
Nestin as a diagnostic and prognostic marker for combined hepatocellular-cholangiocarcinoma
Caldéraro, J., Tommaso, L. D., Maillé, P., Bèaufrere, A., Nguyễn, C. T., Heij, L. R., Gnemmi, V., Graham, R. P., Charlotte, F., Chartier, S., et al. (2022) · Journal of Hepatology · doi:10.1016/j.jhep.2022.07.019 · Cited by 40
Self-citationCast, A. E., Valanejad, L., Wright, M., Nguyen, P., Gupta, A., Zhu, L., Shin, S., & Timchenko, N. A. (2017) · Hepatology · doi:10.1002/hep.29677 · Cited by 40
Lewińska, M., Zhuravleva, E., Satriano, L., Martinez, M. B., Bhatt, D. K., Oliveira, D. V. N. P., Antoku, Y., Keggenhoff, F. L., Castven, D., Marquardt, J. U., et al. (2023) · Gastroenterology · doi:10.1053/j.gastro.2023.11.302 · Cited by 38
Self-citationAnti-tumoral effect of desmethylclomipramine in lung cancer stem cells
Bongiorno‐Borbone, L., Giacobbe, A., Compagnone, M., Eramo, A., Maria, R. D., Peschiaroli, A., & Melino, G. (2015) · Oncotarget · doi:10.18632/oncotarget.4700 · Cited by 38
miR‐9 modulates and predicts the response to radiotherapy and EGFR inhibition in HNSCC
Citron, F., Segatto, I., Musco, L., Pellarin, I., Vinciguerra, G. L. R., Franchin, G., Fanetti, G., Miccichè, F., Giacomarra, V., Lupato, V., et al. (2021) · EMBO Molecular Medicine · doi:10.15252/emmm.202012872 · Cited by 37
Metadata
- Authors
- Tschaharganeh, D. F., Xue, W., Calvisi, D. F., Evert, M., Michurina, T. V., Dow, L. E., Banito, A., Katz, S. F., Kastenhuber, E. R., Weissmueller, S., Huang, C.-H., Lechel, A., Andersen, J. B., Capper, D., Zender, L., Longerich, T., Enikolopov, G., & Lowe, S. W.
- Affiliations
- Memorial Sloan Kettering Cancer Center (US)
- Cold Spring Harbor Laboratory (US)
- Universitätsmedizin Greifswald (DE)
- Universität Ulm (DE)
- University of Copenhagen (DK)
- German Cancer Research Center (DE)
- University Hospital Heidelberg (DE)
- Corresponding author
- Lowe, Scott W.
- ORCID
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2014-07
- Volume
- 158
- Issue
- 3
- Pages
- 579-592
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC4221237
- OpenAlex
- W1980168406
- Cited by
- 227
- References
- 60
- Citations by year
- 2026: 10 · 2025: 13 · 2024: 15 · 2023: 22 · 2022: 21 · 2021: 25 · 2020: 21 · 2019: 24 · 2018: 23 · 2017: 15 · 2016: 20 · 2015: 11 · 2014: 6
- FWCI
- 8.36
- Type
- journal article
- Language
- en
- Update notices
- erratum (2016-06-02)
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) (submittedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institutes of Health (5p30ca045508-35)
- National Cancer Institute (P01CA087497, P30-CA045508, P01CA013106, P30CA008748)
- Topics
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Keywords
- p53, nestin, hepatocellular carcinoma, cholangiocarcinoma, liver cancer, cellular plasticity, dedifferentiation, progenitor-like cells, Wnt signaling, Notch signaling, tumor suppression, transcriptional repression, patient survival
- MeSH terms
- Animals, Cell Transformation, Neoplastic, Carcinoma, Hepatocellular, Humans, Liver Neoplasms, Prognosis, Transcription, Genetic, Tumor Suppressor Protein p53, Sp1 Transcription Factor, Hepatocytes, Mice, Sp3 Transcription Factor, Nestin
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
