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Cited by 381

The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.

Adipsin Is an Adipokine that Improves β Cell Function in Diabetes

Open access
Lo, James C., Ljubicic, Sanda, Leibiger, Barbara, Kern, Matthias, Leibiger, Ingo B., Moede, Tilo, Kelly, Molly E., Chatterjee Bhowmick, Diti, Murano, Incoronata, Cohen, Paul, Banks, Alexander S., Khandekar, Melin J., Dietrich, Arne, Flier, Jeffrey S., Cinti, Saverio, Blüher, Matthias, Danial, Nika N., Berggren, Per-Olof, Spiegelman, Bruce M.·2014·Cell
DOI 10.1016/j.cell.2014.06.005
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Abstract

Summary A hallmark of type 2 diabetes mellitus (T2DM) is the development of pancreatic β cell failure, resulting in insulinopenia and hyperglycemia. We show that the adipokine adipsin has a beneficial role in maintaining β cell function. Animals genetically lacking adipsin have glucose intolerance due to insulinopenia; isolated islets from these mice have reduced glucose-stimulated insulin secretion. Replenishment of adipsin to diabetic mice treated hyperglycemia by boosting insulin secretion. We identify C3a, a peptide generated by adipsin, as a potent insulin secretagogue and show that the C3a receptor is required for these beneficial effects of adipsin. C3a acts on islets by augmenting ATP levels, respiration and cytosolic free Ca2+. Finally, we demonstrate that T2DM patients with β cell failure are deficient in adipsin. These findings indicate that the adipsin/C3a pathway connects adipocyte function to β cell physiology and manipulation of this molecular switch may serve as a novel therapy in T2DM.

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Metadata

Authors
Lo, J. C., Ljubicic, S., Leibiger, B., Kern, M., Leibiger, I. B., Moede, T., Kelly, M. E., Chatterjee Bhowmick, D., Murano, I., Cohen, P., Banks, A. S., Khandekar, M. J., Dietrich, A., Flier, J. S., Cinti, S., Blüher, M., Danial, N. N., Berggren, P.-O., & Spiegelman, B. M.
Venue
Cell
Publisher
Elsevier BV
Published
2014-07
Volume
158
Issue
1
Pages
41-53
ISSN
0092-8674 (ISSN-L)
DOI
10.1016/j.cell.2014.06.005
OpenAlex
W2013710242
Cited by
381
References
63
FWCI
23.30
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Adipsin Is an Adipokine that Improves β Cell Function in Diabetes. https://app.cochat.ai/papers/10.1016/j.cell.2014.06.005
The paper
Lo, J. C., Ljubicic, S., Leibiger, B., Kern, M., Leibiger, I. B., Moede, T., Kelly, M. E., Chatterjee Bhowmick, D., Murano, I., Cohen, P., Banks, A. S., Khandekar, M. J., Dietrich, A., Flier, J. S., Cinti, S., Blüher, M., Danial, N. N., Berggren, P.-O., & Spiegelman, B. M. (2014). Adipsin Is an Adipokine that Improves β Cell Function in Diabetes. Cell. https://doi.org/10.1016/j.cell.2014.06.005

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.