Adipokines in health and disease

Positional cloning of the mouse obese gene and its human homologue

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Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance

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Adipose Tissue as an Endocrine Organ

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Identification and Importance of Brown Adipose Tissue in Adult Humans

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Cold-Activated Brown Adipose Tissue in Healthy Men

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A Novel Serum Protein Similar to C1q, Produced Exclusively in Adipocytes

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Functional Brown Adipose Tissue in Healthy Adults

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Mechanisms linking obesity with cardiovascular disease

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AdipoQ Is a Novel Adipose-specific Gene Dysregulated in Obesity

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Protection from obesity-induced insulin resistance in mice lacking TNF-α function

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FGF-21 as a novel metabolic regulator

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cDNA Cloning and Expression of a Novel Adipose Specific Collagen-like Factor, apM1 (AdiposeMost Abundant Gene Transcript 1)

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Effects of Recombinant Leptin Therapy in a Child with Congenital Leptin Deficiency

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Interleukin-1-receptor antagonist in type 2 diabetes mellitus

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Pharmacology, physiology, and mechanisms of incretin hormone action.

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FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis

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Recombinant Leptin for Weight Loss in Obese and Lean Adults: A Randomized, Controlled, Dose-Escalation Trial

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Relationship between Adipocyte Size and Adipokine Expression and Secretion

Skurk, T., Alberti-Huber, C., Herder, C., & Hauner, H. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-1055 · Cited by 1,288 · see citing works

Adiponectin and protection against type 2 diabetes mellitus

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New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure

Tseng, Y.-H., Kokkotou, E., Schulz, T. J., Huang, T. L., Winnay, J. N., Taniguchi, C. M., Tran, T. T., Suzuki, R., Espinoza, D. O., Yamamoto, Y., et al. (2008) · Nature · doi:10.1038/nature07221 · Cited by 1,099 · see citing works

Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease

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Apelin, a Newly Identified Adipokine Up-Regulated by Insulin and Obesity

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The effects of LY2405319, an FGF21 analog, in obese human subjects with type 2 diabetes

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Insulin-sensitive obesity

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TNF‐α and adipocyte biology

Cawthorn, W. P., & Sethi, J. K. (2007) · FEBS Letters · doi:10.1016/j.febslet.2007.11.051 · Cited by 792 · see citing works

A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity

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Visceral adipose tissue-derived serine protease inhibitor: A unique insulin-sensitizing adipocytokine in obesity

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Adiponectin: mechanistic insights and clinical implications

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Pharmacology, Physiology, and Mechanisms of Action of Dipeptidyl Peptidase-4 Inhibitors

Mulvihill, E. E., & Drucker, D. J. (2014) · Endocrine Reviews · doi:10.1210/er.2014-1035 · Cited by 613 · see citing works

Adipose tissue as a source of hormones

Siiteri, P. K. (1987) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/45.1.277 · Cited by 600 · see citing works

Leptin in Human Physiology and Pathophysiology

Mantzoros, C. S., Magkos, F., Brinkoetter, M., Sienkiewicz, E., Dardeno, T. A., Kim, S.-Y., Hamnvik, O.-P. R., & Koniaris, A. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00315.2011 · Cited by 593 · see citing works

Dipeptidyl Peptidase 4 Is a Novel Adipokine Potentially Linking Obesity to the Metabolic Syndrome

Lamers, D., Famulla, S., Wronkowitz, N., Hartwig, S., Lehr, S., Ouwens, D. M., Eckardt, K., Kaufman, J., Rydén, M., Müller, S., et al. (2011) · Diabetes · doi:10.2337/db10-1707 · Cited by 583 · see citing works

Apelin Stimulates Glucose Utilization in Normal and Obese Insulin-Resistant Mice

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Adipocyte dysfunction, inflammation and metabolic syndrome

Klöting, N., & Blüher, M. (2014) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-014-9301-0 · Cited by 473 · see citing works

Leptin responsiveness restored by amylin agonism in diet-induced obesity: Evidence from nonclinical and clinical studies

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Adipsin: A Circulating Serine Protease Homolog Secreted by Adipose Tissue and Sciatic Nerve

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Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor γ

Wei, W., Dutchak, P. A., Wang, X., Ding, X., Wang, X., Bookout, A. L., Goetz, R., Mohammadi, M., Gerard, R. D., Dechow, P. C., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1200797109 · Cited by 426 · see citing works

The starvation hormone, fibroblast growth factor-21, extends lifespan in mice

Zhang, Y., Xie, Y., Berglund, E. D., Coate, K. C., He, T. T., Katafuchi, T., Xiao, G., Potthoff, M. J., Wei, W., Wan, Y., et al. (2012) · eLife · doi:10.7554/elife.00065 · Cited by 420 · see citing works

Serum Vaspin Concentrations in Human Obesity and Type 2 Diabetes

Youn, B., Klöting, N., Kratzsch, J., Lee, N., Park, J. W., Song, E.-S., Ruschke, K., Oberbach, A., Faßhauer, M., Stümvoll, M., et al. (2007) · Diabetes · doi:10.2337/db07-1045 · Cited by 419 · see citing works

Adipose tissue dysfunction contributes to obesity related metabolic diseases

Blüher, M. (2013) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2013.02.005 · Cited by 407 · see citing works

Serum Retinol-Binding Protein Is More Highly Expressed in Visceral than in Subcutaneous Adipose Tissue and Is a Marker of Intra-abdominal Fat Mass

Klöting, N., Graham, T. E., Berndt, J., Kralisch, S., Kovacs, P. L., Wason, C. J., Faßhauer, M., Schön, M. R., Stümvoll, M., Blüher, M., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.06.002 · Cited by 404 · see citing works

From leptin to other adipokines in health and disease: Facts and expectations at the beginning of the 21st century

Blüher, M., & Mantzoros, C. S. (2014) · Metabolism · doi:10.1016/j.metabol.2014.10.016 · Cited by 399 · see citing works

Regulation of adipocyte lipolysis

Frühbeck, G., Méndez-Giménez, L., Fernández-Formoso, J., Fernández, S., & Rodríguez, A. (2014) · Nutrition research reviews · doi:10.1017/s095442241400002x · Cited by 380 · see citing works

Brown-fat paucity due to impaired BMP signalling induces compensatory browning of white fat

Schulz, T. J., Huang, P. C., Huang, T. L., Xue, R., McDougall, L. E., Townsend, K. L., Cypess, A. M., Mishina, Y. M., Gussoni, E., & Tseng, Y. (2013) · Nature · doi:10.1038/nature11943 · Cited by 378 · see citing works

Adipsin Is an Adipokine that Improves β Cell Function in Diabetes

Lo, J. C., Ljubicic, S., Leibiger, B., Kern, M., Leibiger, I. B., Moede, T., Kelly, M. E., Bhowmick, D. C., Murano, I., Cohen, P., et al. (2014) · Cell · doi:10.1016/j.cell.2014.06.005 · Cited by 376 · see citing works

Adipokines: A treasure trove for the discovery of biomarkers for metabolic disorders

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Enhanced Weight Loss With Pramlintide/Metreleptin: An Integrated Neurohormonal Approach to Obesity Pharmacotherapy

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Severely Impaired Adipsin Expression in Genetic and Acquired Obesity

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Impaired Heart Contractility in Apelin Gene–Deficient Mice Associated With Aging and Pressure Overload

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Apelin, diabetes, and obesity

Castan‐Laurell, I., Dray, C., Attané, C., Duparc, T., Knauf, C., & Valet, P. (2011) · Endocrine · doi:10.1007/s12020-011-9507-9 · Cited by 297 · see citing works

Incretin-Based Therapies for Type 2 Diabetes Mellitus: Properties, Functions, and Clinical Implications

Nauck, M. A. (2010) · The American Journal of Medicine · doi:10.1016/j.amjmed.2010.11.002 · Cited by 293 · see citing works

Adipokines – removing road blocks to obesity and diabetes therapy

Blüher, M. (2014) · Molecular Metabolism · doi:10.1016/j.molmet.2014.01.005 · Cited by 273 · see citing works

Incretin Action in the Pancreas: Potential Promise, Possible Perils, and Pathological Pitfalls

Drucker, D. J. (2013) · Diabetes · doi:10.2337/db13-0822 · Cited by 272 · see citing works

Leptin's Role in Lipodystrophic and Nonlipodystrophic Insulin-Resistant and Diabetic Individuals

Moon, H., Dalamaga, Μ., Kim, S. Y., Pοlyzos, S. A., Hamnvik, O. R., Magkos, F., Paruthi, J., & Mantzoros, C. S. (2013) · Endocrine Reviews · doi:10.1210/er.2012-1053 · Cited by 257 · see citing works

Adiponectin, driver or passenger on the road to insulin sensitivity?

Ye, R., & Scherer, P. E. (2013) · Molecular Metabolism · doi:10.1016/j.molmet.2013.04.001 · Cited by 251 · see citing works

Number and size of adipose tissue fat cells in relation to metabolism in human obesity

Björntorp, P. A., & Sjöström, L. (1971) · Metabolism · doi:10.1016/0026-0495(71)90084-9 · Cited by 243 · see citing works

Identification and Validation of Novel Adipokines Released from Primary Human Adipocytes

Lehr, S., Hartwig, S., Lamers, D., Famulla, S., Müller, S., Hanisch, F., Cuvelier, C. A., Ruige, J. B., Eckardt, K., Ouwens, D. M., et al. (2011) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m111.010504 · Cited by 241 · see citing works

T Cell–Derived IL-22 Amplifies IL-1β–Driven Inflammation in Human Adipose Tissue: Relevance to Obesity and Type 2 Diabetes

Dalmas, É., Venteclef, N., Caer, C., Poitou, C., Cremer, I., Aron‐Wisnewsky, J., Lacroix‐Desmazes, S., Bayry, J., Kaveri, S. V., Clément, K., et al. (2014) · Diabetes · doi:10.2337/db13-1511 · Cited by 240 · see citing works

Effects of weight loss and exercise on chemerin serum concentrations and adipose tissue expression in human obesity

Chakaroun, R., Raschpichler, M., Klöting, N., Oberbach, A., Flehmig, G., Kern, M., Schön, M. R., Shang, E., Lohmann, T., Dreßler, M., et al. (2011) · Metabolism · doi:10.1016/j.metabol.2011.10.008 · Cited by 234 · see citing works

Adipokines in gestational diabetes

Fasshauer, M., Blüher, M., & Stumvoll, M. (2014) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(13)70176-1 · Cited by 230 · see citing works

Weekly Subcutaneous Pegylated Recombinant Native Human Leptin (PEG-OB) Administration in Obese Men

Hukshorn, C. J., Saris, W. H. M., Westerterp-Plantenga, M. S., Farid, A. R., Smith, F. J., & Campfield, L. A. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.11.6955 · Cited by 220 · see citing works

Adipose Dipeptidyl Peptidase-4 and Obesity

Sell, H., Blüher, M., Klöting, N., Schlich, R., Willems, M., Ruppe, F., Knoefel, W. T., Dietrich, A., Fielding, B. A., Arner, P., et al. (2013) · Diabetes Care · doi:10.2337/dc13-0496 · Cited by 219 · see citing works

BMP4 and BMP Antagonists Regulate Human White and Beige Adipogenesis

Gustafson, B., Hammarstedt, A., Hedjazifar, S., Hoffmann, J. M., Svensson, P., Grimsby, J. S., Rondinone, C. M., & Smith, U. (2015) · Diabetes · doi:10.2337/db14-1127 · Cited by 215 · see citing works

Interleukin-1β mediates macrophage-induced impairment of insulin signaling in human primary adipocytes

Gao, D., Madi, M., Ding, C., Fok, M., Steele, T., Ford, C. T., Hunter, L., & Chen, B. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00430.2013 · Cited by 213 · see citing works

The apj receptor is expressed in pancreatic islets and its ligand, apelin, inhibits insulin secretion in mice

Winzell, M. S., Magnusson, C., & Åhrén, B. (2005) · Regulatory Peptides · doi:10.1016/j.regpep.2005.05.004 · Cited by 212 · see citing works

The role of adipokines in β-cell failure of type 2 diabetes

Dunmore, S., & Brown, J. E. P. (2012) · Journal of Endocrinology · doi:10.1530/joe-12-0278 · Cited by 205 · see citing works

Clinical Relevance of Adipokines

Blüher, M. (2012) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2012.36.5.317 · Cited by 202 · see citing works

Inventing new medicines: The FGF21 story

Kharitonenkov, A., & Adams, A. C. (2014) · Molecular Metabolism · doi:10.1016/j.molmet.2013.12.003 · Cited by 198 · see citing works

FGF21 as a Hepatokine, Adipokine, and Myokine in Metabolism and Diseases

Itoh, N. (2014) · Frontiers in Endocrinology · doi:10.3389/fendo.2014.00107 · Cited by 198 · see citing works

Vaspin in obesity and diabetes: pathophysiological and clinical significance

Blüher, M. (2011) · Endocrine · doi:10.1007/s12020-011-9572-0 · Cited by 194 · see citing works

Inflammation links excess fat to insulin resistance: the role of the interleukin‐1 family

Tack, C. J., Stienstra, R., Joosten, L. A. B., & Netea, M. G. (2012) · Immunological Reviews · doi:10.1111/j.1600-065x.2012.01145.x · Cited by 192 · see citing works

Leptin at the Intersection of Neuroendocrinology and Metabolism: Current Evidence and Therapeutic Perspectives

Dalamaga, Μ., Chou, S. H.-H., Shields, K. S., Papageorgiou, P., Pοlyzos, S. A., & Mantzoros, C. S. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.05.010 · Cited by 191 · see citing works

Apelin Decreases Lipolysis via Gq, Gi, and AMPK-Dependent Mechanisms

Yue, P., Jin, H. H., Xu, S., Aillaud, M., Deng, A. C., Azuma, J., Kundu, R. K., Reaven, G. M., Quertermous, T., & Tsao, P. S. (2010) · Endocrinology · doi:10.1210/en.2010-0576 · Cited by 171 · see citing works

The safety and efficacy of OP-1 (rhBMP-7) as a replacement for iliac crest autograft for posterolateral lumbar arthrodesis: minimum 4-year follow-up of a pilot study

Vaccaro, A. R., Whang, P. G., Patel, T. C., Phillips, F. M., Anderson, D. G., Albert, T. J., Hilibrand, A. S., Brower, R. S., Kurd, M. F., Appannagari, A., et al. (2007) · The Spine Journal · doi:10.1016/j.spinee.2007.03.012 · Cited by 169 · see citing works

Serum Progranulin Concentrations May Be Associated With Macrophage Infiltration Into Omental Adipose Tissue

Youn, B., Bang, S. I., Klöting, N., Park, J. W., Lee, N., Oh, J.-E., Pi, K., Lee, T. H., Ruschke, K., Faßhauer, M., et al. (2008) · Diabetes · doi:10.2337/db08-1147 · Cited by 169 · see citing works

Vaspin inhibits kallikrein 7 by serpin mechanism

Heiker, J. T., Klöting, N., Kovacs, P. L., Kuettner, E. B., Sträter, N., Schultz, S., Kern, M., Stümvoll, M., Blüher, M., & Beck‐Sickinger, A. G. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-013-1258-8 · Cited by 166 · see citing works

Central vaspin administration acutely reduces food intake and has sustained blood glucose-lowering effects

Klöting, N., Kovacs, P. L., Kern, M., Heiker, J. T., Faßhauer, M., Schön, M. R., Stümvoll, M., Beck‐Sickinger, A. G., & Blüher, M. (2011) · Diabetologia · doi:10.1007/s00125-011-2137-1 · Cited by 160 · see citing works

Emerging role of bone morphogenetic proteins in adipogenesis and energy metabolism

Schulz, T. J., & Tseng, Y.-H. (2009) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2009.10.019 · Cited by 154 · see citing works

Adiponectin induces insulin secretion in vitro and in vivo at a low glucose concentration

Okamoto, M., Ohara‐Imaizumi, M., Kubota, N., Hashimoto, S., Eto, K., Kanno, T., Kubota, T., Wakui, M., Nagai, R., Noda, M., et al. (2008) · Diabetologia · doi:10.1007/s00125-008-0944-9 · Cited by 150 · see citing works

Regulation of Lipolysis in Small and Large Fat Cells of the Same Subject

Laurencikiene, J., Skurk, T., Kulyté, A., Hedén, P., Åström, G., Sjölin, E., Rydén, M., Hauner, H., & Arner, P. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-1702 · Cited by 148 · see citing works

Shedding of dipeptidyl peptidase 4 is mediated by metalloproteases and up‐regulated by hypoxia in human adipocytes and smooth muscle cells

Röhrborn, D., Eckel, J., & Sell, H. (2014) · FEBS Letters · doi:10.1016/j.febslet.2014.08.029 · Cited by 142 · see citing works

Identification of Adipokine Clusters Related to Parameters of Fat Mass, Insulin Sensitivity and Inflammation

Flehmig, G., Scholz, M. R., Klöting, N., Faßhauer, M., Tönjes, A., Stümvoll, M., Youn, B., & Blüher, M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0099785 · Cited by 140 · see citing works

Adipocyte Size Threshold Matters: Link with Risk of Type 2 Diabetes and Improved Insulin Resistance After Gastric Bypass

Cotillard, A., Poitou, C., Torcivia, A., Bouillot, J., Dietrich, A., Klöting, N., Grégoire, C., Lolmède, K., Blüher, M., & Clément, K. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-1074 · Cited by 139 · see citing works

The WNT Inhibitor Dickkopf 1 and Bone Morphogenetic Protein 4 Rescue Adipogenesis in Hypertrophic Obesity in Humans

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