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Cited by 316

The DOI matches its Crossref record; 261 of the 261 references it cites were found in a registry or an index.

Macrophage functions in lean and obese adipose tissue

Open access
Thomas, Dylan, Apovian, Caroline·2017·Metabolism
DOI 10.1016/j.metabol.2017.04.005
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Abstract

Summary Interactions between macrophages and adipocytes influence both metabolism and inflammation. Obesity-induced changes to macrophages and adipocytes lead to chronic inflammation and insulin resistance. This paper reviews the various functions of macrophages in lean and obese adipose tissue and how obesity alters adipose tissue macrophage phenotypes. Metabolic disease and insulin resistance shift the balance between numerous pro- and anti-inflammatory regulators of macrophages and create a feed-forward loop of increasing inflammatory macrophage activation and worsening adipocyte dysfunction. This ultimately leads to adipose tissue fibrosis and diabetes. The molecular mechanisms underlying these processes have therapeutic implications for obesity, metabolic syndrome, and diabetes.

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Metadata

Authors
Thomas, D., & Apovian, C.
Venue
Metabolism
Publisher
Elsevier BV
Published
2017-07
Volume
72
Pages
120-143
ISSN
0026-0495 (ISSN-L)
DOI
10.1016/j.metabol.2017.04.005
OpenAlex
W2606455926
Cited by
316
References
261
FWCI
19.48
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Macrophage functions in lean and obese adipose tissue. https://app.cochat.ai/papers/10.1016/j.metabol.2017.04.005
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Thomas, D., & Apovian, C. (2017). Macrophage functions in lean and obese adipose tissue. Metabolism. https://doi.org/10.1016/j.metabol.2017.04.005

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.