P7C3 Neuroprotective Chemicals Function by Activating the Rate-Limiting Enzyme in NAD Salvage

Wang, Gelin, Han, Ting, Nijhawan, Deepak, Theodoropoulos, Pano, Naidoo, Jacinth, Yadavalli, Sivaramakrishnan, Mirzaei, Hamid, Pieper, Andrew A., Ready, Joseph M., McKnight, Steven L.·2014·Cell
DOI 10.1016/j.cell.2014.07.040

Cited by (244)

Items 201–244 of 244

  1. Protective effects of the NAMPT activator P7C3-A20 on mouse neuronal injury in diabetic stroke: The role of intracellular NAMPT and SIRT1/FoxO3a signaling
    Yui Iwatani, Hideki Hayashi, Mizuki Minamisawa, Shun Hasegawa, Yoshiyuki Moriyama, Norio Takagi · 2026 · Biomedicine & Pharmacotherapy
  2. P7C3-A20 prevents whole brain radiotherapy-induced chronic hippocampal redox imbalance and neuropsychiatric impairment in mice
    Edwin Vázquez‐Rosa, Min‐Kyoo Shin, Kalyani Chaubey, Sarah Barker, Sofia G. Corella, Suwarna Chakraborty, Sunil Jamuna Tripathi, Youngmin Yu, Jiwon Hyung, Himanshu R. Dashora et al. · 2026 · Redox Biology
  3. Pharmacological Approaches for Modulating Sirtuins
    Alice E. Kane, David A. Sinclair · 2018 · Elsevier eBooks
  4. NAD+ flux is maintained in aged mice
    Melanie R. McReynolds, Karthikeyani Chellappa, Eric N. Chiles, Connor S.R. Jankowski, Yishui Shen, Li Chen, Hélène C. Descamps, Sarmistha Mukherjee, Yashaswini Rajendra Bhat, Qingwei Chu et al. · 2020 · Research Square
  5. Extracellular Hydrolysis of NAD+and its Secondary Metabolites by a new Aspergillus sp
    Thanaa H. Ali, Latifa A. Mohamed · 2021 · Egyptian Journal of Chemistry
  6. A metabolic and mitochondrial angle on aging
    Ana Isabel Duarte, Izabela Sadowska‐Bartosz, Agnieszka Karkucińska‐Więckowska, Magdalena Lebiedzińska, Carlos M. Palmeira, Anabela Pinto Rolo, Yaschar Kabiri, Barbara Zavan, Paolo Pinton, Fernanda Borges et al. · 2022 · Elsevier eBooks
  7. A Decade of Mitochondria‐Targeting Drugs in Cancer Treatment: Case Review on Mitochondria‐Targeting Curcumin or Mitocurcumin
    Rahul Shah, Ryan Varghese, Harsh Anchan, Sanidhya Pai, Tanmay Zagade, Mitul Oswal, Sparsh Agarwal, Purab Sood, Gargi Digholkar, Abha Deshpande et al. · 2025 · Drug Development Research
  8. Targeting NAD Homeostasis: Compartmentalization, Quantification, and Modulation
    Marta Nobile, Veronica Fontanini, Simone Serrao, Johannes Burtscher, Francesca Re, Giuseppe Paglia · 2026 · Metabolites
  9. In silico screening of candidate NAMPT modulators for treatment of age-related diseases
    Jarmila Nahálková, Fernando Berton Zanchi · 2026 · In Silico Research in Biomedicine
  10. Potential significance of NAD+ biology translational research in super-aged Japan
    山口慎太郎, 伊藤 裕, 吉野 純 · 2020 · Nippon Ronen Igakkai Zasshi Japanese Journal of Geriatrics
  11. 烟酰胺腺嘌呤二核苷酸（NAD+）合成代谢及其调控机体衰老研究进展
    Yumeng Li, Xutong Tian, Juyue Luo, Tongtong Bao, Xin Wu · 2024 · Scientia Sinica Vitae
  12. Mitochondria are an Important Target in the Search for new Drugs for the Treatment of Alzheimer′s Disease and Senile Dementia
    E. F. Shevtsova, Daria V. Vinogradova, Маргарита Е. Неганова, Pavel N. Shevtsov, B. V. Lednev, Сергей Олегович Бачурин · 2018 · Biomedical Chemistry Research and Methods
  13. Changes in the functional connectome and behavior after exposure to chronic stress and increasing neurogenesis
    Luka Čulig, Patrick E. Steadman, Justin W. Kenney, Sandra Legendre, Frédéric Minier, René Hen, Paul W. Frankland, Catherine Belzung · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  14. Neuroprotective strategies for traumatic brain injury
    Terry C. Yin · 2015
  15. Target identification: NAD salvages neurons
    Mirella Bucci · 2014 · Nature Chemical Biology
  16. Axon Death Pathways Converge on Axed to Promote Axon Disassembly
    Thomas C. Burdett · 2017 · The Journal of the American Medical Association (JAMA) Network (American Medical Association)
  17. The Neuroprotective Compound P7C3-A20 Promotes Neurogenesis and Improves Functional Outcomes After Focal Cerebral Ischemia
    Zachary B. Loris · 2017
  18. NAD + Modulation
    Elena Katsyuba, Johan H. Auwerx · 2018 · Elsevier eBooks
  19. Mitochondrial Dysfunction in Neurodegenerative Dis-orders and Atherosclerosis: Pathophysiological Mecha-nisms and innovative Protocol Towards an Elegant New Era Of Health
    Abdullah Abdulrhman Al Abdulgader · 2020 · American Journal of Biomedical Science & Research
  20. Circadian Secretion of Glucagon-like Peptide-1
    Alexandre Martchenko · 2020 · TSpace (University of Toronto)
  21. MITOCHONDRIAL DISEASE THERAPY
    Kanika Khajuria, Vijay Khajuria, Vineeta Sawhney · 2021 · Asian Journal of Pharmaceutical and Clinical Research
  22. The Role of NAD+ in Rejuvenating Human Body
    Biotechnology Kiosk, Shyamasri Biswas · 2020 · Biotechnology Kiosk
  23. Anti-inflammatory compounds improve spiral ganglion neuron survival after aminoglycoside-induced hair cell loss in rats
    Muhammad Taifur Rahman, Erin M. Bailey, Benjamin M. Gansemer, Andrew A. Pieper, John Robert Manak, Steven H. Green · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
  24. Faculty Opinions recommendation of Boosting NAD+ with a small molecule that activates NAMPT.
    Shin‐ichiro Imai, Sean Johnson · 2019 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  25. Sirtuin Activators
    Alice E. Kane, David A. Sinclair · 2019 · Elsevier eBooks
  26. Longitudinal in vivo monitoring of axonal integrity after brain injury
    Sergiy Chornyy, Julie A. Borovicka, Davina Patel, Min‐Kyoo Shin, Edwin Vázquez‐Rosa, Emiko Miller, Brigid M. Wilson, Andrew A. Pieper, Hod Dana · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
  27. Design and synthesis of a clickable, photoreactive amino acid p -(4-(but-3-yn-1-yl)benzoyl)- l -phenylalanine for peptide photoaffinity labeling
    Penggang Han, Fuli Wang, Shaoheng Bao, Yao Ge, Xiukun Wan, Jiajia Liu, Hui Jiang · 2023 · RSC Advances
  28. Effect of alternating nicotinamide phosphoribosyltransferase expression levels on mitophagy and pathological symptoms in Alzheimer’s disease mouse models
    Na Zhao, Bo Xu, Jie Lai Xia, Jing Wang, Xianliang Zhang, Qingwei Yan · 2023 · Research Square
  29. NAMPT Activator P7C3-A20 Protects against Tunicamycin-Induced Cell Injury in C2C12 Murine Myoblast Cells
    Naoki Chinen, Wataru Otsu, Yoshiki Kuse, Shinsuke Nakamura, Hideaki Hara, Masamitsu Shimazawa · 2024 · BPB Reports
  30. In silico screening of candidate NAMPT modulators for treatment of age-related diseases
    Jarmila Nahálková, Fernando Berton Zanchi · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  31. Determination of Carbazole Derivatives Associated With Photoelectric Materials in Sediments Using QuEChERS Pretreatment Coupled With Ultra‐High Performance Liquid Chromatography‐High Resolution Mass Spectrometry
    Qiang Fu, Dunfan Yao, Shuqing He, Yun Fang, Guowei Wang, Jianhua Li, Chunqiao Xiao · 2025 · Journal of Separation Science
  32. Adventitial fibroblast-derived NAMPT is associated with vascular remodeling in erythropoietin-induced abdominal aortic aneurysm.
    Xinyi Lyu, Shuqin Ding, Chong-Qing Jiang, Yi-Le Zhou, Jia-Hao Shi, Qi Liu, Ya-Jun Chen, Xianpeng Dai · 2025 · Life Science
  33. Single intravitreal injection of lipid nanoparticles delivering circular mRNA of nicotinamide phosphoribosyltransferase protects against dry AMD
    Hui-Lin Li, Yu Xu, Jian-Shan Mo, Xin-Yuan Zhao, Cai-Ling Zhong, Zi-Wen Jia, Xiao-Long Wang, Ben-Chi Zhao, Yanming Chen, Ke‐wei Zheng et al. · 2026 · Journal of Controlled Release
  34. Pyrimidine and NAD salvage pathways : unexpected allies in the maintenance of genome stability
    Sandra Cunha Silveira · 2018 · theses.fr (ABES)
  35. Rôle de la PARylation sur l’apparition des troubles cardiovasculaires dans la progéria de Hutchinson-Gilford
    Déborah Cardoso · 2022 · theses.fr (ABES)
  36. Parkinson’s Disease: Immunometabolic Control Points Across Neural, Vascular, and Peripheral Systems
    Felix Narvaez Irizarry, Alondra M. Bermudez Adorno, Boris S. Ermolinsky, Lilia Y. Kucheryavykh, Mikhail Y. Inyushin · 2026 · Parkinson s Disease
  37. P7C3 Compounds as Targeted Mitochondrial Therapeutics for Brain Disorders
    Yajing Chen, Xiaohuan Du, Fang Li, Shuwei Yuan, Wenjing Wang, Zengyan Zhu, Mei Wang, Chao Gu · 2026 · CNS Neuroscience & Therapeutics
  38. Identification of Novel N-(Aryl)-3-(N-benzylsulfamoyl)benzamides as NAMPT Activators
    Fikriye Özgencil, Gökçen Eren · 2026 · EMU Journal of Pharmaceutical Sciences
  39. P7C3: A novel multi-target therapeutic strategy to combat disuse-related bone loss in space and on earth
    Fei Wei, Christopher Ngo, Craig J. Neal, Jonathan D. Schwartzman, Abinaya Sindu Pugazhendhi, Mahmoud Omer, Christine Dailey Walck, Sudipta Seal, Melanie Jean Coathup · 2026 · Metabolism
  40. BindingDB Entry 50021266: Discovery of a Potent Nicotinamide Phosphoribosyltransferase Activator for Improving Aging-associated Dysfunctions.
    BindingDB · 2025 · UC San Diego
  41. BindingDB Entry 50021758: Drug discovery targeting nicotinamide phosphoribosyltransferase (NAMPT): Updated progress and perspectives.
    BindingDB · 2025 · UC San Diego
  42. BindingDB Entry 50049198: Identification of Novel Triazole-Based Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors Endowed with Antiproliferative and Antiinflammatory Activity.
    BindingDB · 2019 · UC San Diego
  43. BindingDB Entry 50020096: Nicotinamide Phosphoribosyltransferase Positive Allosteric Modulators Attenuate Neuronal Oxidative Stress.
    BindingDB · 2024 · UC San Diego
  44. BindingDB Entry 50017776: Optimization of NAMPT activators to achieve in vivo neuroprotective efficacy.
    BindingDB · 2023 · UC San Diego