McKnight, Steven L.

The Leucine Zipper: A Hypothetical Structure Common to a New Class of DNA Binding Proteins

Landschulz, W. H., Johnson, P. F., & McKnight, S. L. (1988) · Science

Protein Structure and DynamicsGenomics and Chromatin Dynamics

Cited by 3,443

A conserved family of prolyl-4-hydroxylases that modify HIF

Bruick, R. K., & McKnight, S. L. (2001) · Science

Cancer, Hypoxia, and MetabolismErythropoietin and Anemia Treatment

Cited by 2,549

Cell-free Formation of RNA Granules: Low Complexity Sequence Domains Form Dynamic Fibers within Hydrogels

Kato, M., Han, T. W., Xie, S., Shi, K., Du, X., Wu, L. C., Mirzaei, H., Goldsmith, E. J., Longgood, J., Pei, J., et al. (2012) · Cell

RNA Research and SplicingRNA and protein synthesis mechanisms

Cited by 2,012

Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells.

Cao, Z., Umek, R. M., & McKnight, S. L. (1991) · Genes & Development

Peroxisome Proliferator-Activated ReceptorsAdipose Tissue and Metabolism

Cited by 1,663

Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells.

Tian, H., McKnight, S. L., & Russell, D. W. (1997) · Genes & Development

Angiogenesis and VEGF in CancerCancer, Hypoxia, and Metabolism

Cited by 1,351

Regulation of clock and NPAS2 DNA binding by the redox state of NAD cofactors

Rutter, J., Reick, M., Wu, L. C., & McKnight, S. L. (2001) · Science

Circadian rhythm and melatoninPlant Molecular Biology Research

Cited by 1,059

Influence of Metabolism on Epigenetics and Disease

Kaelin, W. G., & McKnight, S. L. (2013) · Cell

Epigenetics and DNA MethylationCancer, Hypoxia, and Metabolism

Cited by 920

CCAAT-Enhancer Binding Protein: A Component of a Differentiation Switch

Umek, R. M., Friedman, A. D., & McKnight, S. L. (1991) · Science

Peroxisome Proliferator-Activated ReceptorsAdipose Tissue and Metabolism

Cited by 712

Acetate dependence of tumors

Comerford, S. A., Huang, Z., Du, X., Wang, Y., Cai, L., Witkiewicz, A. K., Walters, H., Tantawy, M. N., Fu, A., Manning, H. C., et al. (2014) · Cell

Cancer, Lipids, and MetabolismCancer, Hypoxia, and Metabolism

Cited by 681

The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development

Tian, H., Hammer, R. E., Matsumoto, A. M., Russell, D. W., & McKnight, S. L. (1998) · Genes & Development

Congenital heart defects researchNeuroscience of respiration and sleep

Cited by 647

Tissue-specific expression, developmental regulation, and genetic mapping of the gene encoding CCAAT/enhancer binding protein.

Birkenmeier, E. H., Gwynn, B., Howard, S., Jerry, J., Gordon, J. I., Landschulz, W. H., & McKnight, S. L. (1989) · Genes & Development

Genomics and Chromatin DynamicsPeroxisome Proliferator-Activated Receptors

Cited by 613

Identification of a rat liver nuclear protein that binds to the enhancer core element of three animal viruses.

Johnson, P. F., Landschulz, W. H., Graves, B. J., & McKnight, S. L. (1987) · Genes & Development

Genomics and Chromatin DynamicsPolyomavirus and related diseases

Cited by 595

NPAS2: an analog of clock operative in the mammalian forebrain

Reick, M., Garcia, J. A., Dudley, C., & McKnight, S. L. (2001) · Science

Circadian rhythm and melatoninSleep and Wakefulness Research

Cited by 572

Altered patterns of sleep and behavioral adaptability in NPAS2-deficient mice

Dudley, C. A., Erbel-Sieler, C., Estill, S. J., Reick, M., Franken, P., Pitts, S., & McKnight, S. L. (2003) · Science

Circadian rhythm and melatoninSleep and Wakefulness Research

Cited by 415

Ultrastructural patterns of RNA synthesis during early embryogenesis of drosophila melanogaster

McKnight, S. L., & Miller Jr., O. L. (1976) · Cell

Genomics and Chromatin DynamicsNuclear Structure and Function

Cited by 400

The Structure of GABPα/β: An ETS Domain- Ankyrin Repeat Heterodimer Bound to DNA

Batchelor, A. H., Piper, D. E., de la Brousse, F. C., McKnight, S. L., & Wolberger, C. (1998) · Science

Genomics and Chromatin DynamicsProtein Structure and Dynamics

Cited by 291

Specificities of protein-protein and protein-DNA interaction of GABP alpha and two newly defined ets-related proteins.

Brown, T. A., & McKnight, S. L. (1992) · Genes & Development

Genomics and Chromatin DynamicsHerpesvirus Infections and Treatments

Cited by 265

Components of a stat recognition code: Evidence for two layers of molecular selectivity

Schindler, U., Wu, P., Rothe, M., Brasseur, M., & McKnight, S. L. (1995) · Immunity

Cytokine Signaling Pathways and Interactionsinterferon and immune responses

Cited by 246

P7C3 Neuroprotective Chemicals Function by Activating the Rate-Limiting Enzyme in NAD Salvage

Wang, G., Han, T., Nijhawan, D., Theodoropoulos, P., Naidoo, J., Yadavalli, S., Mirzaei, H., Pieper, A. A., Ready, J. M., & McKnight, S. L. (2014) · Cell

Sirtuins and Resveratrol in MedicineNeuroprotection in Cerebral Ischemia

Cited by 243

Metabolic cycles as an underlying basis of biological oscillations.

Tu, B. P., & McKnight, S. L. (2006) · Nature Reviews Molecular Cell Biology

Circadian rhythm and melatoninPhysiological and biochemical adaptations

Cited by 229

Behavioral and regulatory abnormalities in mice deficient in the NPAS1 and NPAS3 transcription factors

Erbel-Sieler, C., Dudley, C., Zhou, Y., Wu, X., Estill, S. J., Han, T., Diaz-Arrastia, R., Brunskill, E. W., Potter, S. S., & McKnight, S. L. (2004) · Proceedings of the National Academy of Sciences

Schizophrenia research and treatmentNeuroscience and Neuropharmacology Research

Cited by 178

Identification of two polypeptide segments of CCAAT/enhancer-binding protein required for transcriptional activation of the serum albumin gene.

Friedman, A. D., & McKnight, S. L. (1990) · Genes & Development

Genomics and Chromatin DynamicsCytokine Signaling Pathways and Interactions

Cited by 162

Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of amyotrophic lateral sclerosis

Tesla, R., Wolf, H. P., Xu, P., Drawbridge, J., Estill, S. J., Huntington, P., McDaniel, L., Knobbe, W., Burket, A., Tran, S., et al. (2012) · Proceedings of the National Academy of Sciences

Amyotrophic Lateral Sclerosis ResearchAlzheimer's disease research and treatments

Cited by 129

Delineation of transcriptional control signals within the Moloney murine sarcoma virus long terminal repeat.

Graves, B. J., Eisenman, R. N., & McKnight, S. L. (1985) · Molecular and Cellular Biology

Genomics and Chromatin DynamicsT-cell and Retrovirus Studies

Cited by 85