The DOI matches its Crossref record; 61 of the 61 references it cites were found in a registry or an index.
Interchromosomal Homology Searches Drive Directional ALT Telomere Movement and Synapsis
Open accessAbstract
Summary Telomere length maintenance is a requisite feature of cellular immortalization and a hallmark of human cancer. While most human cancers express telomerase activity, approximately 10-15% employ a recombination-dependent telomere maintenance pathway known as Alternative Lengthening of Telomeres (ALT) that is characterized by multi-telomere clusters and associated promyelocytic leukemia protein bodies. Here, we show that a DNA double-strand break (DSB) response at ALT telomeres triggers long-range movement and clustering between chromosome termini, resulting in homology-directed telomere synthesis. Damaged telomeres initiate increased random surveillance of nuclear space before displaying rapid directional movement and association with recipient telomeres over micron-range distances. This phenomenon required Rad51 and the Hop2-Mnd1 heterodimer, which are essential for homologous chromosome synapsis during meiosis. These findings implicate a specialized homology searching mechanism in ALT dependent telomere maintenance and provide a molecular basis underlying the preference for recombination between non- sister telomeres during ALT.
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Metadata
- Authors
- Cho, N. W., Dilley, R. L., Lampson, M. A., & Greenberg, R. A.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2014-09
- Volume
- 159
- Issue
- 1
- Pages
- 108-121
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W1972984145
- Cited by
- 372
- References
- 61
- FWCI
- 17.30
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Cho, N. W., Dilley, R. L., Lampson, M. A., & Greenberg, R. A. (2014). Interchromosomal Homology Searches Drive Directional ALT Telomere Movement and Synapsis. Cell. https://doi.org/10.1016/j.cell.2014.08.030
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