The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Coreceptor Scanning by the T Cell Receptor Provides a Mechanism for T Cell Tolerance
Open accessAbstract
Summary In the thymus, high affinity, self-reactive thymocytes are eliminated from the pool of developing T cells, generating central tolerance. Here, we investigate how developing T cells measure self-antigen affinity. We show that very few CD4 or CD8 coreceptor molecules are coupled with the signal-initiating kinase, Lck. To initiate signaling, an antigen engaged T cell receptor (TCR) scans multiple coreceptor molecules to find one that is coupled to Lck. Coreceptor scanning is the first and rate-limiting step in a kinetic proofreading chain of events that eventually leads to TCR triggering and negative selection. MHCII-restricted TCRs require a shorter antigen dwell time (~0.2s) to initiate negative selection compared to MHCI restricted TCRs (~0.9s) because more CD4 coreceptors are Lck-loaded compared to CD8. Based on experimental data and mathematical analysis, we generated a model (Lck come&stay/signal duration) that accurately predicts the experimentally observed differences in antigen dwell-time thresholds used by MHCI- and MHCII-restricted thymocytes to initiate negative selection and generate self-tolerance.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Smith-Garvin, J. E., Koretzky, G. A., & Jordan, M. S. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132706 · Cited by 2,144
Cited by
CD45 functions as a signaling gatekeeper in T cells
Courtney, A. H., Shvets, A. A., Lu, W., Griffante, G., Mollenauer, M., Horkova, V., Lo, W.-L., Yu, S., Stepanek, O., Chakraborty, A. K., et al. (2019) · Science Signaling · doi:10.1126/scisignal.aaw8151 · Cited by 161
Self-citationOptogenetic control shows that kinetic proofreading regulates the activity of the T cell receptor
Yousefi, O. S., Günther, M., Hörner, M., Chalupsky, J., Wess, M., Brandl, S. M., Smith, R. W., Fleck, C., Kunkel, T., Zurbriggen, M. D., et al. (2019) · eLife · doi:10.7554/elife.42475 · Cited by 117
Jennings, E., Elliot, T. A. E., Thawait, N., Kanabar, S., Yam-Puc, J. C., Ono, M., Toellner, K.-M., Wraith, D. C., Anderson, G., & Bending, D. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108328 · Cited by 94
Yablonski, D. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01704 · Cited by 53
TCR catch bonds nonlinearly control CD8 cooperation to shape T cell specificity
Qin, R., Zhang, Y., Shi, J., Wu, P., An, C., Li, Z., Liu, N., Wan, Z., Hua, T., Li, X., et al. (2025) · Cell Research · doi:10.1038/s41422-025-01077-9 · Cited by 35
Metadata
- Authors
- Stepanek, O., Prabhakar, A. S., Osswald, C., King, C. G., Bulek, A., Naeher, D., Beaufils-Hugot, M., Abanto, M. L., Galati, V., Hausmann, B., Lang, R., Cole, D. K., Huseby, E. S., Sewell, A. K., Chakraborty, A. K., & Palmer, E.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2014-10
- Volume
- 159
- Issue
- 2
- Pages
- 333-345
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2055736811
- Cited by
- 160
- References
- 1
- FWCI
- 6.61
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Coreceptor Scanning by the T Cell Receptor Provides a Mechanism for T Cell Tolerance. https://app.cochat.ai/papers/10.1016/j.cell.2014.08.042
- The paper
- Stepanek, O., Prabhakar, A. S., Osswald, C., King, C. G., Bulek, A., Naeher, D., Beaufils-Hugot, M., Abanto, M. L., Galati, V., Hausmann, B., Lang, R., Cole, D. K., Huseby, E. S., Sewell, A. K., Chakraborty, A. K., & Palmer, E. (2014). Coreceptor Scanning by the T Cell Receptor Provides a Mechanism for T Cell Tolerance. Cell. https://doi.org/10.1016/j.cell.2014.08.042
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
