Dopamine Controls Systemic Inflammation through Inhibition of NLRP3 Inflammasome

The Inflammasomes

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Gout-associated uric acid crystals activate the NALP3 inflammasome

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Cutting Edge: NF-κB Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

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The NALP3 inflammasome is involved in the innate immune response to amyloid-β

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The Inflammasomes: Guardians of the Body

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Comparison of Dopamine and Norepinephrine in the Treatment of Shock

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The Inflammasome NLRs in Immunity, Inflammation, and Associated Diseases

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Monoamine signaling and neuroinflammation: mechanistic connections and implications for neuropsychiatric disorders

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Kisspeptin/GPR54 signaling restricts antiviral innate immune response through regulating calcineurin phosphatase activity

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Suppression of Presymptomatic Oxidative Stress and Inflammation in Neurodegeneration by Grape-Derived Polyphenols

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Emodin attenuated severe acute pancreatitis via the P2X ligand‑gated ion channel�7/NOD‑like receptor protein�3 signaling pathway

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Advances in immunotherapy for the treatment of spinal cord injury

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Study on Hepatotoxicity of Rhubarb Based on Metabolomics and Network Pharmacology

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Edaravone Plays Protective Effects on LPS-Induced Microglia by Switching M1/M2 Phenotypes and Regulating NLRP3 Inflammasome Activation

Li, J., Dai, X., Zhou, L., Li, X., & Pan, D. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.691773 · Cited by 39

Cardiolipin oxidized by ROS from complex II acts as a target of gasdermin D to drive mitochondrial pore and heart dysfunction in endotoxemia

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NLRP3 inflammasome in atherosclerosis: Mechanisms and targeted therapies

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EphA2 phosphorylates NLRP3 and inhibits inflammasomes in airway epithelial cells

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Dopaminergic signalling limits suppressive activity and gut homing of regulatory T cells upon intestinal inflammation

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NLRP3 inflammasome inhibitor cucurbitacin B suppresses gout arthritis in mice

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Phosphodiesterase 3B (PDE3B) regulates NLRP3 inflammasome in adipose tissue

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Dopamine and norepinephrine are embracing their immune side and so should we

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The role of caloric load and mitochondrial homeostasis in the regulation of the NLRP3 inflammasome

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Catecholic Isoquinolines fromPortulaca oleraceaand Their Anti-inflammatory and β2-Adrenergic Receptor Agonist Activity

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The BRCC3 regulated by Cdk5 promotes the activation of neuronal NLRP3 inflammasome in Parkinson’s disease models

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Does NLRP3 Inflammasome and Aryl Hydrocarbon Receptor Play an Interlinked Role in Bowel Inflammation and Colitis-Associated Colorectal Cancer?

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Nano-engineered nerolidol loaded lipid carrier delivery system attenuates cyclophosphamide neurotoxicity – Probable role of NLRP3 inflammasome and caspase-1

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Dopamine enhances the response of sunitinib in the treatment of drug-resistant breast cancer: Involvement of eradicating cancer stem-like cells

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Protective Effects of Asiatic Acid Against Spinal Cord Injury-Induced Acute Lung Injury in Rats

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Prospective Role of Polyphenolic Compounds in the Treatment of Neurodegenerative Diseases

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The AST-120 Recovers Uremic Toxin-Induced Cognitive Deficit via NLRP3 Inflammasome Pathway in Astrocytes and Microglia

Li, L., Chen, W., Chen, J., Lee, W., Chang, C., Tzeng, H., Huang, C.-C., Chang, Y., & Yang, J. (2021) · Biomedicines · doi:10.3390/biomedicines9091252 · Cited by 38

Dopamine‐Integrated Nanointerface between Fibrillar Matrix and Hydrophilic Nanohydroxyapatite Regulates Immune Microenvironment to Boost Endogenous Bone Regeneration

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Parkinson’s Disease and Photobiomodulation: Potential for Treatment

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Molecular mechanisms of NLRP3 inflammasome activation

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Triggering of inflammasome by impaired autophagy in response to acute experimental Parkinson’s disease

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An update on cell intrinsic negative regulators of the NLRP3 inflammasome

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Inflammasome activation and regulation during Helicobacter pylori pathogenesis

Kumar, S., & Dhiman, M. (2018) · Microbial Pathogenesis · doi:10.1016/j.micpath.2018.10.012 · Cited by 38

Atherothrombosis and the NLRP3 inflammasome – endogenous mechanisms of inhibition

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β-Lactolin, a Whey-Derived Lacto-Tetrapeptide, Prevents Alzheimer’s Disease Pathologies and Cognitive Decline

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Dopamine D1 receptor agonist A-68930 ameliorates Aβ1-42-induced cognitive impairment and neuroinflammation in mice

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Dopamine improves chemotherapeutic efficacy for pancreatic cancer by regulating macrophage-derived inflammations

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Ubc13 Promotes K63-Linked Polyubiquitination of NLRP3 to Activate Inflammasome

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Salidroside alleviates liver inflammation in furan-induced mice by regulating oxidative stress and endoplasmic reticulum stress

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A multifunctional chitosan composite aerogel based on high density amidation for chronic wound healing

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Dopamine Triggers CTCF-Dependent Morphological and Genomic Remodeling of Astrocytes

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Relationship between Circulating Inflammation Proteins and Lung Cancer Diagnosis in the National Lung Screening Trial

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ADP/P2Y1 aggravates inflammatory bowel disease through ERK5-mediated NLRP3 inflammasome activation

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Bacterial secretion systems and regulation of inflammasome activation

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Olfactory Neuron Prokineticin‐2 as a Potential Target in Parkinson's Disease

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Neural mechanisms underlying adaptive and maladaptive consequences of stress: Roles of dopaminergic and inflammatory responses

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Off label use of Aripiprazole shows promise as a treatment for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): a retrospective study of 101 patients treated with a low dose of Aripiprazole

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KP-10/Gpr54 attenuates rheumatic arthritis through inactivating NF-κB and MAPK signaling in macrophages

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Parkinson Disease: Translating Insights from Molecular Mechanisms to Neuroprotection

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BAG3 promotes autophagy and suppresses NLRP3 inflammasome activation in Parkinson’s disease

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Neuroinflammation in Age-Related Neurodegenerative Diseases: Role of Mitochondrial Oxidative Stress

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Cinnamic acid nanoparticles modulate redox signal and inflammatory response in gamma irradiated rats suffering from acute pancreatitis

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Dopamine induces functional extracellular traps in microglia

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Inflammasome activation in neurodegenerative diseases

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Calpain activation and progression of inflammatory cycles in Parkinson’s disease

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Glymphatic System and Mitochondrial Dysfunction as Two Crucial Players in Pathophysiology of Neurodegenerative Disorders

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Theaflavin mitigates acute gouty peritonitis and septic organ injury in mice by suppressing NLRP3 inflammasome assembly

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Inhibition of dopamine receptor D3 signaling in dendritic cells increases antigen cross-presentation to CD8+ T-cells favoring anti-tumor immunity

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The expressions of NLRP1, NLRP3, and AIM2 inflammasome complexes in the contusive spinal cord injury rat model and their responses to hormonal therapy

Majidpoor, J., Khezri, Z., Rostamzadeh, P., Mortezaee, K., Rezaie, M. J., Fathi, F., Abouzaripour, M., Bariki, M. G., Moradi, F., Shirazi, R., et al. (2020) · Cell and Tissue Research · doi:10.1007/s00441-020-03250-5 · Cited by 33

Inflammatory Mechanisms in Parkinson’s Disease: From Pathogenesis to Targeted Therapies

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Galectin-9 Targets NLRP3 for Autophagic Degradation to Limit Inflammation

Wang, W., Qin, Y., Song, H., Wang, L., Jia, M., Zhao, C., Gong, M., & Zhao, W. (2021) · The Journal of Immunology · doi:10.4049/jimmunol.2001404 · Cited by 33

Exosomes Regulate NLRP3 Inflammasome in Diseases

Li, Z., Chen, X., Tao, J., Shi, A., Zhang, J., & Yu, P. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.802509 · Cited by 36

The association between the neuroendocrine system and the tumor immune microenvironment: Emerging directions for cancer immunotherapy

Li, J., Che, M., Zhang, B., Zhao, K., Wan, C., & Yang, K. (2023) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2023.189007 · Cited by 33

Mesenchymal Stromal Cells Directly Promote Inflammation by Canonical NLRP3 and Non-canonical Caspase-11 Inflammasomes

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Mechanisms of Action of Autophagy Modulators Dissected by Quantitative Systems Pharmacology Analysis

Shi, Q., Pei, F., Silverman, G. A., Pak, S. C., Perlmutter, D. H., Liu, B., & Bahar, İ. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21082855 · Cited by 31

Lower CSF homovanillic acid relates to higher burden of neuroinflammation and depression in people with HIV disease

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Pristimerin protects against inflammation and metabolic disorder in mice through inhibition of NLRP3 inflammasome activation

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USP21 Deubiquitinase Regulates AIM2 Inflammasome Activation

Hong, Y., Lee, S.-O., Oh, C., Kang, K., Ryoo, J., Kim, D., & Ahn, K. (2021) · The Journal of Immunology · doi:10.4049/jimmunol.2100449 · Cited by 31

Dopaminergic Signaling as a Plausible Modulator of Astrocytic Toll-Like Receptor 4: A Crosstalk between Neuroinflammation and Cognition

Nampoothiri, M., Gurram, P. C., Manandhar, S., Satarker, S., Mudgal, J., & Arora, D. S. (2022) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527321666220413090541 · Cited by 33

Contributive Role of TNF-α to L-DOPA-Induced Dyskinesia in a Unilateral 6-OHDA Lesion Model of Parkinson’s Disease

Pereira, M. D. S., de Abreu, G. H. D., Rocca, J., Hamadat, S., Raisman‐Vozari, R., Michel, P. P., & Bel, E. A. D. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.617085 · Cited by 35

Proximity proteomics reveals UCH-L1 as an essential regulator of NLRP3-mediated IL-1β production in human macrophages and microglia

Liang, Z., Damianou, A., Vendrell, I., Jenkins, E. M., Lassen, F. H., Washer, S. J., Grigoriou, A., Liu, G., Yi, G., Lou, H., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114152 · Cited by 35

Neurodegenerative diseases and neuroinflammation-induced apoptosis

Huang, S., Lu, Y., Fang, W., Huang, Y., Li, Q., & Xu, Z. (2025) · Open Life Sciences · doi:10.1515/biol-2022-1051 · Cited by 32

Tumor Necrosis Factor-Like Weak Inducer of Apoptosis (TWEAK) Enhances Activation of STAT3/NLRC4 Inflammasome Signaling Axis through PKCδ in Astrocytes: Implications for Parkinson’s Disease

Samidurai, M., Tarale, P., Janarthanam, C., Gomez-Estrada, C., Gordon, R., Zenitsky, G. D., Jin, H., Anantharam, V., Kanthasamy, A. G., & Kanthasamy, A. (2020) · Cells · doi:10.3390/cells9081831 · Cited by 31

Activation and Regulation of NLRP3 by Sterile and Infectious Insults

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Neutrophil extracellular traps-mediated Beclin-1 suppression aggravates atherosclerosis by inhibiting macrophage autophagy

Sano, M., Maejima, Y., Nakagama, S., Shiheido‐Watanabe, Y., Tamura, N., Hirao, K., Isobe, M., & Sasano, T. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.876147 · Cited by 33

DTX3L induced NLRP3 ubiquitination inhibit R28 cell pyroptosis in OGD/R injury

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Melatonin ameliorates spinal cord injury by suppressing the activation of inflammasomes in rats

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Saikosaponin-d alleviates depression by promoting NLRP3 ubiquitination and inhibiting inflammasome activation

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Role of NLRP3 in Parkinson's disease: Specific activation especially in dopaminergic neurons

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Polycatechols inhibit ferroptosis and modulate tau liquid–liquid phase separation to mitigate Alzheimer's disease

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Sleep deprivation-induced cognitive impairment: Unraveling the role of neuroinflammation

Yuan, X., & Wang, C. (2025) · Experimental Neurology · doi:10.1016/j.expneurol.2025.115419 · Cited by 39

Huaier aqueous extract protects against dextran sulfate sodium-induced experimental colitis in mice by inhibiting NLRP3 inflammasome activation

Wang, L., Yu, Z., Wei, C., Zhang, L., Song, H., Chen, B., & Yang, Q. (2017) · Oncotarget · doi:10.18632/oncotarget.16513 · Cited by 30

Impairment of gill structural integrity by manganese deficiency or excess related to induction of oxidative damage, apoptosis and dysfunction of the physical barrier as regulated by NF-κB, caspase and Nrf2 signaling in fish

Jiang, W., Tang, R.-J., Liu, Y., Wu, P., Kuang, S., Jiang, J., Tang, L., Tang, W., Zhang, Y., Zhou, X., et al. (2017) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2017.09.022 · Cited by 30

Actinidia arguta extract attenuates inflammasome activation: Potential involvement in NLRP3 ubiquitination

Heo, K.-H., Sun, X. Y., Shim, D.-W., Kim, M.-K., Koppula, S., Yu, S., Kim, H.-B., Kim, T., Kang, T., & Lee, K. (2017) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2017.11.023 · Cited by 31

Dopaminergic Pathways in Obesity-Associated Inflammation

Leite, F., & Ribeiro, L. V. P. T. (2019) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-019-09863-0 · Cited by 34

Preservation of mitochondrial homeostasis is responsible for the ameliorative effects of Suhuang antitussive capsule on non-resolving inflammation via inhibition of NF-κB signaling and NLRP3 inflammasome activation

Qin, W., Tong, X., Liang, R., Tang, K., Wu, X., Jia, Y., & Tan, N. (2021) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2021.113827 · Cited by 30

Bicarbonate, carbon dioxide and pH sensing via mammalian bicarbonate-regulated soluble adenylyl cyclase

Rossetti, T., Jackvony, S., Buck, J., & Levin, L. R. (2021) · Interface Focus · doi:10.1098/rsfs.2020.0034 · Cited by 30

Molecular mechanisms of cordycepin emphasizing its potential against neuroinflammation: An update

Govindula, A., Pai, A., Baghel, S. S., & Mudgal, J. (2021) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2021.174364 · Cited by 32

The Chinese Medicine Babaodan Suppresses LPS-Induced Sepsis by Inhibiting NLRP3-Mediated Inflammasome Activation

Li, Y., Sheng, H., Qian, J., & Wáng, Y. (2022) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2022.115205 · Cited by 30

Prognostic Neurotransmitter Receptors Genes Are Associated with Immune Response, Inflammation and Cancer Hallmarks in Brain Tumors

Belotti, Y., Tolomeo, S., Yu, R., Lim, W., & Lim, C. T. (2022) · Cancers · doi:10.3390/cancers14102544 · Cited by 31

Anti-Inflammatory Effects of Peripheral Dopamine

Moore, S. C., de Castro, P. A. S. V., Yaqub, D., José, P. A., & Armando, I. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241813816 · Cited by 32

Implication of the LRR Domain in the Regulation and Activation of the NLRP3 Inflammasome

Cescato, M., Zhu, Y. Y. J., Corre, L. L., Py, B. F., Georgin‐Lavialle, S., & Rodero, M. P. (2024) · Cells · doi:10.3390/cells13161365 · Cited by 32

Biosynthesis of Lysosomally Escaped Apoptotic Bodies Inhibits Inflammasome Synthesis in Macrophages

Mao, J., Xia, W., Wu, Y., Li, M., Zhao, Y., Zhai, P., Zhang, Y., Zan, T., Cui, W., & Sun, X. (2024) · Research · doi:10.34133/research.0581 · Cited by 29

Sex differences in effects of gestational polychlorinated biphenyl exposure on hypothalamic neuroimmune and neuromodulator systems in neonatal rats

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Modulatory mechanisms of NLRP3: Potential roles in inflammasome activation

Ge, Q., Chen, X., Zhao, Y., Mu, H., & Zhang, J. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118918 · Cited by 32

Applications and Mechanism of 3‐Hydroxybutyrate (3HB) for Prevention of Colonic Inflammation and Carcinogenesis as a Food Supplement

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Posttranslational modifications of NLRP3 and their regulatory roles in inflammasome activation

Qin, Y., & Zhao, W. (2023) · European Journal of Immunology · doi:10.1002/eji.202350382 · Cited by 30

Genome-wide transcriptional profiling of central amygdala and orbitofrontal cortex during incubation of methamphetamine craving

Cates, H. M., Li, X., Purushothaman, I., Kennedy, P., Shen, L., Shaham, Y., & Nestler, E. J. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0158-x · Cited by 32

Dopamine Alters Lipopolysaccharide-Induced Nitric Oxide Production in Microglial Cells via Activation of D1-Like Receptors

Wang, B., Chen, T., Li, G., Jia, Y., Wang, J., Li, X., & Chen, Y. (2019) · Neurochemical Research · doi:10.1007/s11064-019-02730-7 · Cited by 30

Nutritional values, bioactive compounds and health benefits of purslane ( Portulaca oleracea L.): a comprehensive review

Li, Y., Xiao, L., Yan, H., Wu, M., Hao, X., & Liu, H. (2023) · Food Science and Human Wellness · doi:10.26599/fshw.2022.9250203 · Cited by 28

Cichorium intybus Linn. Extract Prevents Type 2 Diabetes Through Inhibition of NLRP3 Inflammasome Activation

Shim, D.-W., Han, J., Ji, Y.-E., Shin, W.-Y., Koppula, S., Kim, M.-K., Kim, T.-K., Park, P., Kang, T., & Lee, K. (2016) · Journal of Medicinal Food · doi:10.1089/jmf.2015.3556 · Cited by 28

Dopamine alleviated acute liver injury induced by lipopolysaccharide/ d -galactosamine in mice

Zhou, H., Li, T., Yang, Y., Lin, L., Dai, J., Ge, P., Ai, Q., Jiang, R., & Zhang, L. (2018) · International Immunopharmacology · doi:10.1016/j.intimp.2018.06.004 · Cited by 28

LncRNA ANRIL promotes angiogenesis and thrombosis by modulating microRNA-99a and microRNA-449a in the autophagy pathway.

Zeng, R., Song, X., Liu, C., & Ye, W. (2019) · Europe PMC (PubMed Central) · Cited by 28

Dopamine blocks inflammasome activation

Bordon, Y. (2015) · Nature reviews. Immunology · doi:10.1038/nri3817

Dopamine controls NLRP3

Dempsey, L. A. (2015) · Nature Immunology · doi:10.1038/ni.3110

The role of dopamine in NLRP3 inflammasome inhibition: Implications for neurodegenerative diseases

Possemato, E., Barbera, L. L., Nobili, A., Krashia, P., & D’Amelio, M. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.101907 · Cited by 76

Anti-inflammatory Effects of Dopamine in Lipopolysaccharide (LPS)-stimulated RAW264.7 Cells via Inhibiting NLRP3 Inflammasome Activation.

Liu, A., & Ding, S. (2019) · PubMed · Cited by 24

Dual Impact of Dopamine on NLRP3 Inflammasome: Priming Signal and Mitochondria-Mediated Activation in Human Monocyte-Derived Macrophages (Abstract ID: 159736)

Daniali, M., Channer, B., Matt, S. M., Kist, T., & Gaskill, P. J. (2025) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/j.jpet.2024.100662