Tian, Zhigang

Functional exhaustion of antiviral lymphocytes in COVID-19 patients

Zheng, M., Gao, Y., Wang, G., Song, G., Liu, S., Sun, D., Xu, Y., & Tian, Z. (2020) · Cellular & Molecular Immunology

SARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research Studies

Cited by 1,768

Pathogenic T-cells and inflammatory monocytes incite inflammatory storms in severe COVID-19 patients

Zhou, Y., Fu, B., Zheng, X., Wang, D., Zhao, C., Qi, Y., Sun, R., Tian, Z., Xu, X., & Wei, H. (2020) · National Science Review

COVID-19 Clinical Research StudiesSARS-CoV-2 and COVID-19 Research

Cited by 1,295

Dopamine controls systemic inflammation through inhibition of NLRP3 inflammasome

Yan, Y., Jiang, W., Liu, L., Wang, X., Ding, C., Tian, Z., & Zhou, R. (2015) · Cell

Inflammasome and immune disordersImmune Response and Inflammation

Cited by 1,014

Liver: An organ with predominant innate immunity

Gao, B., Jeong, W.-I., & Tian, Z. (2008) · Hepatology

Liver physiology and pathologyImmune Response and Inflammation

Cited by 952

Omega-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome activation

Yan, Y., Jiang, W., Spinetti, T., Tardivel, A., Castillo, R., Bourquin, C., Guarda, G., Tian, Z., Tschopp, J., & Zhou, R. (2013) · Immunity

Inflammasome and immune disordersFatty Acid Research and Health

Cited by 784

T cell anergy, exhaustion, senescence, and stemness in the tumor microenvironment

Crespo, J., Sun, H., Welling, T. H., Tian, Z., & Zou, W. (2013) · Current Opinion in Immunology

T-cell and B-cell ImmunologyCancer Immunotherapy and Biomarkers

Cited by 752

NK cell-based immunotherapy for malignant diseases

Cheng, M., Chen, Y., Xiao, W., Sun, R., & Tian, Z. (2013) · Cellular & Molecular Immunology

Immune Cell Function and InteractionImmunotherapy and Immune Responses

Cited by 631

Natural Killer Cells Ameliorate Liver Fibrosis by Killing Activated Stellate Cells in NKG2D-Dependent and Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand–Dependent Manners

Radaeva, S., Sun, R., Jaruga, B., Nguyen, V. T., Tian, Z., & Gao, B. (2006) · Gastroenterology

Liver physiology and pathologyImmune Cell Function and Interaction

Cited by 610

Respiratory influenza virus infection induces intestinal immune injury via microbiota-mediated Th17 cell-dependent inflammation

Wang, J., Li, F., Wei, H., Lian, Z.-X., Sun, R., & Tian, Z. (2014) · Journal of Experimental Medicine

Influenza Virus Research StudiesGut microbiota and health

Cited by 490

A pan-cancer single-cell panorama of human natural killer cells

Tang, F., Li, J., Qi, L., Liu, D., Bo, Y., Qin, S., Miao, Y., Yu, K., Hou, W., Li, J., et al. (2023) · Cell

Immune Cell Function and InteractionCancer Immunotherapy and Biomarkers

Cited by 450

Mitochondrial fragmentation limits NK cell-based tumor immunosurveillance

Zheng, X., Qian, Y., Fu, B., Jiao, D., Jiang, Y., Chen, P., Shen, Y., Zhang, H., Sun, R., Tian, Z., et al. (2019) · Nature Immunology

Immune Cell Function and InteractionMitochondrial Function and Pathology

Cited by 316

Developmental and Functional Control of Natural Killer Cells by Cytokines

Wu, Y., Tian, Z., & Wei, H. (2017) · Frontiers in Immunology

Immune Cell Function and InteractionImmune cells in cancer

Cited by 269

Bacterial colonization dampens influenza-mediated acute lung injury via induction of M2 alveolar macrophages

Wang, J., Li, F., Sun, R., Gao, X., Wei, H., Li, L.-J., & Tian, Z. (2013) · Nature Communications

Influenza Virus Research StudiesImmune Response and Inflammation

Cited by 239

Expression of leptin receptors and response to leptin stimulation of human natural killer cell lines

Zhao, Y., Sun, R., You, L., Gao, C., & Tian, Z. (2003) · Biochemical and Biophysical Research Communications

Immune Cell Function and InteractionCytokine Signaling Pathways and Interactions

Cited by 229

The microbiota maintain homeostasis of liver-resident γδT-17 cells in a lipid antigen/CD1d-dependent manner

Li, F., Hao, X., Chen, Y., Bai, L., Gao, X., Lian, Z., Wei, H., Sun, R., & Tian, Z. (2017) · Nature Communications

T-cell and B-cell ImmunologyGut microbiota and health

Cited by 191

Elevated interleukin-6 during ethanol consumption acts as a potential endogenous protective cytokine against ethanol-induced apoptosis in the liver: involvement of induction of Bcl-2 and Bcl-xL proteins

Hong, F., Kim, W.-H., Tian, Z., Jaruga, B., Ishac, E., Shen, X., & Gao, B. (2002) · Oncogene

Alcohol Consumption and Health EffectsCell death mechanisms and regulation

Cited by 179

Blocking the natural killer cell inhibitory receptor NKG2A increases activity of human natural killer cells and clears hepatitis B virus infection in mice

Li, F., Wei, H., Wei, H., Gao, Y., Xu, L., Yin, W., Sun, R., & Tian, Z. (2013) · Gastroenterology

Immune Cell Function and InteractionHepatitis B Virus Studies

Cited by 164

Liver-Resident NK Cells Control Antiviral Activity of Hepatic T Cells via the PD-1-PD-L1 Axis

Zhou, J., Peng, H., Li, K., Qu, K., Wang, B., Wu, Y., Ye, L., Dong, Z., Wei, H., Sun, R., et al. (2019) · Immunity

Immune Cell Function and InteractionT-cell and B-cell Immunology

Cited by 157

Increased susceptibility to liver injury in hepatitis B virus transgenic mice involves NKG2D-ligand interaction and natural killer cells

Chen, Y., Wei, H., Sun, R., Dong, Z., Zhang, J., & Tian, Z. (2007) · Hepatology

Hepatitis B Virus StudiesImmune Cell Function and Interaction

Cited by 130

Kupffer Cell-Derived IL-10 Plays a Key Role in Maintaining Humoral Immune Tolerance in Hepatitis B Virus-Persistent Mice

Xu, L., Yin, W., Sun, R., Wei, H., & Tian, Z. (2014) · Hepatology

Hepatitis B Virus StudiesT-cell and B-cell Immunology

Cited by 100

Growth inhibition of human hepatocellular carcinoma cells by blocking STAT3 activation with decoy-ODN

Sun, X., Zhang, J., Wang, L., & Tian, Z. (2008) · Cancer Letters

Cytokine Signaling Pathways and InteractionsHepatocellular Carcinoma Treatment and Prognosis

Cited by 80

NK cell development requires Tsc1-dependent negative regulation of IL-15-triggered mTORC1 activation

Yang, M., Chen, S., Du, J., He, J., Wang, Y., Li, Z., Liu, G., Peng, W., Zeng, X., Li, D., et al. (2016) · Nature Communications

Immune Cell Function and InteractionT-cell and B-cell Immunology

Cited by 73

Oral ampicillin inhibits liver regeneration by breaking hepatic innate immune tolerance normally maintained by gut commensal bacteria

Wu, X., Sun, R., Chen, Y., Zheng, X., Bai, L., Lian, Z., Wei, H., & Tian, Z. (2015) · Hepatology

Liver physiology and pathologyLiver Diseases and Immunity

Cited by 71

NK Cells Help Induce Anti–Hepatitis B Virus CD8+ T Cell Immunity in Mice

Zheng, M., Sun, R., Wei, H., & Tian, Z. (2016) · The Journal of Immunology

Hepatitis B Virus StudiesImmune Cell Function and Interaction

Cited by 68