The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.
Immune Regulation of Metabolic Homeostasis in Health and Disease
Open accessAbstract
Obesity is an increasingly prevalent disease worldwide. While genetic and environmental factors are known to regulate the development of obesity and associated metabolic diseases, emerging studies indicate that innate and adaptive immune cell responses in adipose tissue have critical roles in the regulation of metabolic homeostasis. In the lean state, type 2 cytokine-associated immune cell responses predominate in white adipose tissue and protect against weight gain and insulin resistance through direct effects on adipocytes and elicitation of beige adipose. In obesity, these metabolically beneficial immunologic pathways become dysregulated, and adipocytes and other factors initiate metabolically deleterious type 1 inflammation that impairs glucose metabolism. This review discusses our current understanding of the functions of different types of adipose tissue, how immune cells regulate adipocyte function and metabolic homeostasis in the context of health and disease, and highlights the potential of targeting immuno-metabolic pathways as a therapeutic strategy to treat obesity and associated diseases.
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Cites
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Cited by
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“Although a mechanistic relationship between inflammation andmetabolic dysfunction has been demonstrated in rodent models (Berg and Scherer, 2005; Brestoff and Artis, 2015; Ferrante, 2007; Hotamisligil, 2006; Hotamisligil et al., 1995; Sun et al., 2013), the importance of low-grade inflammation in the pathogenesis of o…”
PPARs in Obesity-Induced T2DM, Dyslipidaemia and NAFLD
Gross, B., Pawlak, M., Lefebvre, P., & Staels, B. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.135 · Cited by 778
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López-Otín, C., Galluzzi, L., Freije, J. M. P., Madeo, F., & Kroemer, G. (2016) · Cell · doi:10.1016/j.cell.2016.07.031 · Cited by 753
Metadata
- Authors
- Brestoff, J. R., & Artis, D.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2015-03
- Volume
- 161
- Issue
- 1
- Pages
- 146-160
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W1967896870
- Cited by
- 497
- References
- 54
- FWCI
- 36.69
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
