The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.
Hepatitis C Virus RNA Functionally Sequesters miR-122
Open accessAbstract
Summary Hepatitis C virus uniquely requires the liver specific microRNA-122 for replication, yet global effects on endogenous miRNA targets during infection are unexplored. Here, high-throughput sequencing and crosslinking immunoprecipitation (HITS-CLIP) experiments of human Argonaute (Ago) during HCV infection showed robust Ago binding on the HCV 5′UTR, at known and predicted miR-122 sites. On the human transcriptome, we observed reduced Ago binding and functional mRNA de-repression of miR-122 targets during virus infection. This miR-122 “sponge” effect was relieved and redirected to miR-15 targets by swapping the miRNA tropism of the virus. Single-cell expression data from reporters containing miR-122 sites showed significant de-repression during HCV infection depending on expression level and site number. We describe a quantitative mathematical model of HCV induced miR-122 sequestration and propose that such miR-122 inhibition by HCV RNA may result in global de-repression of host miR-122 targets, providing an environment fertile for the long-term oncogenic potential of HCV.
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Self-citation
Metadata
- Authors
- Luna, J. M., Scheel, T. K. H., Danino, T., Shaw, K. S., Mele, A., Fak, J. J., Nishiuchi, E., Takacs, C. N., Catanese, M. T., de Jong, Y. P., Jacobson, I. M., Rice, C. M., & Darnell, R. B.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2015-03
- Volume
- 160
- Issue
- 6
- Pages
- 1099-1110
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W1986944906
- Cited by
- 332
- References
- 63
- FWCI
- 16.00
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Luna, J. M., Scheel, T. K. H., Danino, T., Shaw, K. S., Mele, A., Fak, J. J., Nishiuchi, E., Takacs, C. N., Catanese, M. T., de Jong, Y. P., Jacobson, I. M., Rice, C. M., & Darnell, R. B. (2015). Hepatitis C Virus RNA Functionally Sequesters miR-122. Cell. https://doi.org/10.1016/j.cell.2015.02.025
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