Endogenous microRNA sponges: evidence and controversy
Abstract
The competitive endogenous RNA (ceRNA) hypothesis proposes that transcripts with shared microRNA (miRNA) binding sites compete for post-transcriptional control. This hypothesis has gained substantial attention as a unifying function for long non-coding RNAs, pseudogene transcripts and circular RNAs, as well as an alternative function for messenger RNAs. Empirical evidence supporting the hypothesis is accumulating but not without attracting scepticism. Recent studies that model transcriptome-wide binding-site abundance suggest that physiological changes in expression of most individual transcripts will not compromise miRNA activity. In this Review, we critically evaluate the evidence for and against the ceRNA hypothesis to assess the impact of endogenous miRNA-sponge interactions.
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circRNAs, which have been proposed to act as miRNA sponges, could influence miRNA arm availability by sequestering miRNAs that have target sites within the circRNA.
“It is also possible that circRNAs, which have been proposed to act as miRNA sponges (reviewed in Kristensen et al., 2019; Thomson & Dinger, 2016), could influence miRNA arm availability by sequestering miRNAs that have target sites within the circRNA.”
From microRNA strand selection: Unwinding the rules (2021) · cites this paper as Thomson & Dinger, 2016
Cites
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The biogenesis, biology and characterization of circular RNAs
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“Although these do not alter the GBA coding region, they could affect expression and function, for example by acting as a competing endogenous microRNA sponge 33 .”
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Engineered retrons generate genome-independent protein-binding DNA for cellular control
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- Authors
- Thomson, D. W., & Dinger, M. E.
- Venue
- Nature Reviews Genetics
- Published
- 2016-04-04
- Volume
- 17
- Issue
- 5
- Pages
- 272-283
- ISSN
- 1471-0056
- 1471-0064
- Cited by
- 1,833
- References
- 9
- Language
- en
- Licence
- www.springer.com/tdm (tdm)
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