The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Vagal Sensory Neuron Subtypes that Differentially Control Breathing
Open accessAbstract
SUMMARY Breathing is essential for survival and under precise neural control. The vagus nerve is a major conduit between lung and brain required for normal respiration. Here, we identify two populations of mouse vagus nerve afferents (P2ry1, Npy2r), each a few hundred neurons, that exert powerful and opposing effects on breathing. Genetically guided anatomical mapping revealed that these neurons densely innervate the lung and send long-range projections to different brainstem targets. Npy2r neurons are largely slow-conducting C fibers, while P2ry1 neurons are largely fast-conducting A fibers that contact pulmonary endocrine cells (neuroepithelial bodies). Optogenetic stimulation of P2ry1 neurons acutely silences respiration, trapping animals in exhalation, while stimulating Npy2r neurons causes rapid, shallow breathing. Activating P2ry1 neurons did not impact heart rate or gastric pressure, other autonomic functions under vagal control. Thus, the vagus nerve contains intermingled sensory neurons constituting genetically definable labeled lines with different anatomical connections and physiological roles.
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Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels
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Cited by
Chan, K. Y., Jang, M. J., Yoo, B. B., Greenbaum, A., Ravi, N., Wu, W.-L., Sánchez-Guardado, L., Lois, C., Mazmanian, S. K., Deverman, B. E., et al. (2017) · Nature Neuroscience · doi:10.1038/nn.4593 · Cited by 1,578
Interoception and Mental Health: A Roadmap.
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Sensory neurons that detect stretch and nutrients in the digestive system
Williams, E. K., Chang, R. B., Strochlic, D. E., Umans, B. D., Lowell, B. B., & Liberles, S. D. (2016) · Cell · doi:10.1016/j.cell.2016.05.011 · Cited by 645
Neural regulation of immunity: molecular mechanisms and clinical translation
Pavlov, V. A., & Tracey, K. J. (2017) · Nature Neuroscience · doi:10.1038/nn.4477 · Cited by 532
Metadata
- Authors
- Chang, R. B., Strochlic, D. E., Williams, E. K., Umans, B. D., & Liberles, S. D.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2015-04
- Volume
- 161
- Issue
- 3
- Pages
- 622-633
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2090597220
- Cited by
- 439
- References
- 10
- FWCI
- 9.66
- Type
- journal article
- Language
- en
- Open access
- bronze
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