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Cited by 375

The DOI matches its Crossref record; 61 of the 61 references it cites were found in a registry or an index.

Transbilayer Lipid Interactions Mediate Nanoclustering of Lipid-Anchored Proteins

Open access
Raghupathy, Riya, Anilkumar, Anupama Ambika, Polley, Anirban, Singh, Parvinder Pal, Yadav, Mahipal, Johnson, Charles, Suryawanshi, Sharad, Saikam, Varma, Sawant, Sanghapal D., Panda, Aniruddha, Guo, Zhongwu, Vishwakarma, Ram A., Rao, Madan, Mayor, Satyajit·2015·Cell
DOI 10.1016/j.cell.2015.03.048
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Abstract

SUMMARY Understanding how functional lipid domains in live cell membranes are generated has posed a challenge. Here, we show that transbilayer interactions are necessary for the generation of cholesteroldependent nanoclusters of GPI-anchored proteins mediated by membrane-adjacent dynamic actin filaments. We find that long saturated acyl-chains are required for forming GPI-anchor nanoclusters. Simultaneously, at the inner leaflet, long acyl-chaincontaining phosphatidylserine (PS) is necessary for transbilayer coupling. All-atom molecular dynamics simulations of asymmetric multicomponent-membrane bilayers in a mixed phase provide evidence that immobilization of long saturated acyl-chain lipids at either leaflet stabilizes cholesterol-dependent transbilayer interactions forming local domains with characteristics similar to a liquid-ordered (lo) phase. This is verified by experiments wherein immobilization of long acyl-chain lipids at one leaflet effects transbilayer interactions of corresponding lipids at the opposite leaflet. This suggests a general mechanism for the generation and stabilization of nanoscale cholesterol-dependent and actin-mediated lipid clusters in live cell membranes.

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Metadata

Authors
Raghupathy, R., Anilkumar, A. A., Polley, A., Singh, P. P., Yadav, M., Johnson, C., Suryawanshi, S., Saikam, V., Sawant, S. D., Panda, A., Guo, Z., Vishwakarma, R. A., Rao, M., & Mayor, S.
Venue
Cell
Publisher
Elsevier BV
Published
2015-04
Volume
161
Issue
3
Pages
581-594
ISSN
0092-8674 (ISSN-L)
DOI
10.1016/j.cell.2015.03.048
OpenAlex
W2092150552
Cited by
375
References
61
FWCI
15.57
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Transbilayer Lipid Interactions Mediate Nanoclustering of Lipid-Anchored Proteins. https://app.cochat.ai/papers/10.1016/j.cell.2015.03.048
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Raghupathy, R., Anilkumar, A. A., Polley, A., Singh, P. P., Yadav, M., Johnson, C., Suryawanshi, S., Saikam, V., Sawant, S. D., Panda, A., Guo, Z., Vishwakarma, R. A., Rao, M., & Mayor, S. (2015). Transbilayer Lipid Interactions Mediate Nanoclustering of Lipid-Anchored Proteins. Cell. https://doi.org/10.1016/j.cell.2015.03.048

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.