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Using Genome-scale Models to Predict Biological Capabilities

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O’Brien, Edward J., Monk, Jonathan M., Palsson, Bernhard O.·2015·Cell
DOI 10.1016/j.cell.2015.05.019
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Abstract

Constraint-based reconstruction and analysis (COBRA) methods at the genome-scale have been under development since the first whole genome sequences appeared in the mid-1990s. A few years ago this approach began to demonstrate the ability to predict a range of cellular functions including cellular growth capabilities on various substrates and the effect of gene knockouts at the genome-scale. Thus, much interest has developed in understanding and applying these methods to areas such as metabolic engineering, antibiotic design, and organismal and enzyme evolution. This primer will get you started.

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Cited by

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Metadata

Authors
O’Brien, E. J., Monk, J. M., & Palsson, B. O.
Venue
Cell
Publisher
Elsevier BV
Published
2015-05
Volume
161
Issue
5
Pages
971-987
ISSN
0092-8674 (ISSN-L)
DOI
10.1016/j.cell.2015.05.019
OpenAlex
W2148044817
Cited by
726
References
17
FWCI
23.67
Type
journal article
Language
en
Open access
bronze
Licence
Funders
  • Novo Nordisk Fonden
  • National Institutes of Health (R01 GM057089)

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