The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Systems Properties of the Haemophilus influenzaeRd Metabolic Genotype
Open accessAbstract
Haemophilus influenzae Rd was the first free-living organism for which the complete genomic sequence was established. The annotated sequence and known biochemical information was used to define the H. influenzae Rd metabolic genotype. This genotype contains 488 metabolic reactions operating on 343 metabolites. The stoichiometric matrix was used to determine the systems characteristics of the metabolic genotype and to assess the metabolic capabilities of H. influenzae. The need to balance cofactor and biosynthetic precursor production during growth on mixed substrates led to the definition of six different optimal metabolic phenotypes arising from the same metabolic genotype, each with different constraining features. The effects of variations in the metabolic genotype were also studied, and it was shown that the H. influenzae Rd metabolic genotype contains redundant functions under defined conditions. We thus show that the synthesis of in silico metabolic genotypes from annotated genome sequences is possible and that systems analysis methods are available that can be used to analyze and interpret phenotypic behavior of such genotypes.
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Cites
Cluster analysis and display of genome-wide expression patterns
Eisen, M. B., Spellman, P. T., Brown, P. O., & Botstein, D. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.25.14863 · Cited by 16,184
The complete genome sequence of the gastric pathogen Helicobacter pylori
Tomb, J.-F., White, O., Kerlavage, A. R., Clayton, R. A., Sutton, G. G., Fleischmann, R. D., Ketchum, K. A., Klenk, H. P., Gill, S., Dougherty, B. A., et al. (1997) · Nature · doi:10.1038/41483 · Cited by 3,529
The genome sequence of Rickettsia prowazekii and the origin of mitochondria
Andersson, S. G. E., Zomorodipour, A., Andersson, J. O., Sicheritz-Pontén, T., Alsmark, U. C. M., Podowski, R. M., Näslund, A. K., Eriksson, A.-S., Winkler, H. H., & Kurland, C. G. (1998) · Nature · doi:10.1038/24094 · Cited by 1,697
Cited by
The effects of alternate optimal solutions in constraint-based genome-scale metabolic models
Mahadevan, R., & Schilling, C. H. (2003) · Metabolic Engineering · doi:10.1016/j.ymben.2003.09.002 · Cited by 1,203
Genome-Scale Reconstruction of the Saccharomyces cerevisiae Metabolic Network
Förster, J., Famili, I., Fu, P., Palsson, B. Ø., & Nielsen, J. (2003) · Genome Research · doi:10.1101/gr.234503 · Cited by 1,069
Self-citationEdwards, J. S., & Palsson, B. O. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.10.5528 · Cited by 875
Self-citationConstraining the metabolic genotype–phenotype relationship using a phylogeny of in silico methods
Lewis, N. E., Nagarajan, H., & Palsson, B. O. (2012) · Nature Reviews Microbiology · doi:10.1038/nrmicro2737 · Cited by 779
Self-citationMetabolic modelling of microbes: the flux‐balance approach
Edwards, J. S., Covert, M., & Palsson, B. (2002) · Environmental Microbiology · doi:10.1046/j.1462-2920.2002.00282.x · Cited by 365
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Metadata
- Authors
- Edwards, J. S., & Palsson, B. O.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1999-06
- Volume
- 274
- Issue
- 25
- Pages
- 17410-17416
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1996791690
- Cited by
- 440
- References
- 3
- FWCI
- 3.70
- Type
- journal article
- Language
- en
- Open access
- hybrid
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