Neuroinflammatory TNFα Impairs Memory via Astrocyte Signaling

Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus

Srinivas, S., Watanabe, T., Lin, C.-S., William, C. M., Tanabe, Y., Jessell, T. M., & Costantini, F. (2001) · BMC Developmental Biology · doi:10.1186/1471-213x-1-4 · Cited by 3,121

NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease

Paoletti, P., Bellone, C., & Zhou, Q. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3504 · Cited by 2,523

Cognitive impairment in multiple sclerosis

Chiaravalloti, N. D., & DeLuca, J. (2008) · The Lancet Neurology · doi:10.1016/s1474-4422(08)70259-x · Cited by 2,088

Astrocyte-Neuron Lactate Transport Is Required for Long-Term Memory Formation

Suzuki, A., Stern, S. A., Bozdagi, O., Huntley, G. W., Walker, R. H., Magistretti, P. J., & Alberini, C. M. (2011) · Cell · doi:10.1016/j.cell.2011.02.018 · Cited by 1,711

Optogenetic stimulation of a hippocampal engram activates fear memory recall

Liu, X., Ramirez, S., Pang, P. T., Puryear, C. B., Govindarajan, A., Deisseroth, K. A., & Tonegawa, S. (2012) · Nature · doi:10.1038/nature11028 · Cited by 1,669

Immune modulation of learning, memory, neural plasticity and neurogenesis

Yirmiya, R., & Goshen, I. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2010.10.015 · Cited by 1,483

Control of Synaptic Strength by Glial TNFα

Beattie, E. C., Stellwagen, D., Morishita, W., Bresnahan, J. C., Ha, B. K., Von Zastrow, M., Beattie, M. S., & Malenka, R. C. (2002) · Science · doi:10.1126/science.1067859 · Cited by 1,344

Gliotransmitters Travel in Time and Space

Araque, A., Carmignoto, G., Haydon, P. G., Oliet, S. H. R., Robitaille, R., & Volterra, A. (2014) · Neuron · doi:10.1016/j.neuron.2014.02.007 · Cited by 1,308

Astrocytic Purinergic Signaling Coordinates Synaptic Networks

Pascual, O., Casper, K. B., Kubera, C., Zhang, J., Revilla-Sanchez, R., Sul, J.-Y., Takano, H., Moss, S. J., McCarthy, K., & Haydon, P. G. (2005) · Science · doi:10.1126/science.1116916 · Cited by 1,280

Mice lacking the tumour necrosis factor receptor 1 are resistant to IMF-mediated toxicity but highly susceptible to infection by Listeria monocytogenes

Rothe, J., Lesslauer, W., Loetscher, H., Lang, Y., Koebel, P., Köntgen, F., Althage, A., Zinkernagel, R. M., Steinmetz, M., & Bluethmann, H. (1993) · Nature · doi:10.1038/364798a0 · Cited by 1,246

Exercise protects from hippocampal inflammation and neurodegeneration in experimental autoimmune encephalomyelitis

Rizzo, F. R., Guadalupi, L., Sanna, K., Vanni, V., Fresegna, D., Vito, F. D., Musella, A., Caioli, S., Balletta, S., Bullitta, S., et al. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.08.212 · Cited by 48

Function of Glia in Aging and the Brain Diseases

Vallés, S. L., Iradi, A., Aldasoro, M., Vila, J. M., Aldasoro, C., de la Torre, J., Campos-Campos, J., & Jorda, A. (2019) · International Journal of Medical Sciences · doi:10.7150/ijms.37769 · Cited by 45

Interface astrogliosis in contact sport head impacts and military blast exposure

Babcock, K. J., Abdolmohammadi, B., Kiernan, P. T., Mahar, I., Cherry, J. D., Alvarez, V. E., Goldstein, L. E., Stein, T. D., McKee, A. C., & Huber, B. R. (2022) · Acta Neuropathologica Communications · doi:10.1186/s40478-022-01358-z · Cited by 46

‘Hippocampal innate inflammatory gliosis only’ in pharmacoresistant temporal lobe epilepsy

Grote, A., Heiland, D. H., Taube, J., Helmstaedter, C., Ravi, V. M., Will, P., Hattingen, E., Schüre, J., Witt, J., Reimers, A., et al. (2022) · Brain · doi:10.1093/brain/awac293 · Cited by 43

Astrocyte Role in Temporal Lobe Epilepsy and Development of Mossy Fiber Sprouting

Twible, C., Abdo, R., & Zhang, Q. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.725693 · Cited by 44

Controlling synchronization of gamma oscillations by astrocytic modulation in a model hippocampal neural network

Makovkin, S., Александрович, К. Е., Ivanchenko, M., & Gordleeva, S. (2022) · Scientific Reports · doi:10.1038/s41598-022-10649-3 · Cited by 44

Microglial Phagocytosis—Rational but Challenging Therapeutic Target in Multiple Sclerosis

Pinto, M. V., & Fernandes, A. M. A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21175960 · Cited by 42

Astrocytes functionally integrate multiple synapses via specialized leaflet domains

Benoit, L., Hristovska, I., Liaudet, N., Jouneau, P., Fertin, A., Ceglia, R. D., Litvin, D. G., Castro, M. A. D., Jevtic, M., Zalachoras, I., et al. (2025) · Cell · doi:10.1016/j.cell.2025.08.036 · Cited by 48

Dexibuprofen prevents neurodegeneration and cognitive decline in APPswe/PS1dE9 through multiple signaling pathways

Ettcheto, M., Sánchez‐López, E., Pons, L., Busquets, O., Olloquequi, J., Beas‐Zárate, C., Pallàs, M., García, M. L., Auladell, C., Folch, J., et al. (2017) · Redox Biology · doi:10.1016/j.redox.2017.06.003 · Cited by 39

Circuit-specific control of the medial entorhinal inputs to the dentate gyrus by atypical presynaptic NMDARs activated by astrocytes

Savtchouk, I., Castro, M. A. D., Ali, R., Stubbe, H., Luján, R., & Volterra, A. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1816013116 · Cited by 38

Electroacupuncture reduces astrocyte number and oxidative stress in aged rats with surgery-induced cognitive dysfunction

Liu, P., Cao, F., Zhang, Y., & Peng, S. (2019) · Journal of International Medical Research · doi:10.1177/0300060519860026 · Cited by 37

Central Nervous System: (Immunological) Ivory Tower or Not?

Marin, I. A., & Kipnis, J. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.122 · Cited by 36

Microorganisms in the Placenta: Links to Early-Life Inflammation and Neurodevelopment in Children

Tomlinson, M. S., Lü, K., Stewart, J. R., Marsit, C. J., O’Shea, T. M., & Fry, R. C. (2019) · Clinical Microbiology Reviews · doi:10.1128/cmr.00103-18 · Cited by 38

Microglia modulate TNFα ‐mediated synaptic plasticity

Kleidonas, D., Kirsch, M., Andrieux, G., Pfeifer, D., Boerries, M., & Vlachos, A. (2023) · Glia · doi:10.1002/glia.24383 · Cited by 37

Differential effects of peripheral and brain tumor necrosis factor on inflammation, sickness, emotional behavior and memory in mice

Klaus, F., Paterna, J., Marzorati, E., Sigrist, H., Goetze, L., Schwendener, S., Bergamini, G., Jehli, E., Azzinnari, D., Fuertig, R., et al. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.08.001 · Cited by 37

Specialized functions of resident macrophages in brain and heart

Nicolás-Ávila, J. Á., Hidalgo, A., & Ballesteros, I. (2018) · Journal of Leukocyte Biology · doi:10.1002/jlb.6mr0118-041r · Cited by 36

Anti-aging effects of Ribes meyeri anthocyanins on neural stem cells and aging mice

Gao, J., Wu, Y., He, D., Zhu, X., Li, H., Liu, H., & Liu, H. (2020) · Aging · doi:10.18632/aging.103955 · Cited by 35

Molecular Mechanisms in the Genesis of Seizures and Epilepsy Associated With Viral Infection

Löscher, W., & Howe, C. L. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.870868 · Cited by 35

(Putative) sex differences in neuroimmune modulation of memory

Tronson, N. C., & Collette, K. M. (2016) · Journal of Neuroscience Research · doi:10.1002/jnr.23921 · Cited by 36

Neuronal impairment following chronic Toxoplasma gondii infection is aggravated by intestinal nematode challenge in an IFN-γ-dependent manner

French, T., Düsedau, H. P., Steffen, J., Biswas, A., Ahmed, N., Hartmann, S., Schüler, T., Schott, B. H., & Dunay, I. R. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1539-8 · Cited by 33

Coxsackievirus Adenovirus Receptor Loss Impairs Adult Neurogenesis, Synapse Content, and Hippocampus Plasticity

Zussy, C., Loustalot, F., Junyent, F., Gardoni, F., Bories, C., Valero, J., Desarménien, M. G., Bernex, F., Henaff, D., Bayó-Puxan, N., et al. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.0132-16.2016 · Cited by 37

Pathophysiological Links Between Obesity and Dementia

Zhang, D. E. W., Tran, V., Vinh, A., Dinh, Q. N., Drummond, G. R., Sobey, C. G., Jelinic, M., & Silva, T. M. D. (2023) · NeuroMolecular Medicine · doi:10.1007/s12017-023-08746-1 · Cited by 36

Tumor necrosis factor α negatively regulates the retrieval and reconsolidation of hippocampus-dependent memory

Takahashi, S., Fukushima, H., Yu, Z., Tomita, H., & Kida, S. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.02.033 · Cited by 33

Neuropsychiatric Disorders Due to Limbic Encephalitis: Immunologic Aspect

Kao, Y.-C., Lin, M.-I., Weng, W., & Lee, W. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms22010389 · Cited by 33

Synapse Dysfunctions in Multiple Sclerosis

Schwarz, K., & Schmitz, F. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24021639 · Cited by 36

Exocytosis in Astrocytes

Mielnicka, A., & Michaluk, P. (2021) · Biomolecules · doi:10.3390/biom11091367 · Cited by 31

Interleukin 1β receptor and synaptic dysfunction in recurrent brain infection with Herpes simplex virus type-1

Piacentini, R., & Grassi, C. (2024) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-23-01690 · Cited by 30

Early Preclinical Changes in Hippocampal CREB-Binding Protein Expression in a Mouse Model of Familial Alzheimer’s Disease

Ettcheto, M., Abad, S., Petrov, D., Pedrós, I., Busquets, O., Sánchez‐López, E., Casadesús, G., Beas‐Zárate, C., Carro, E., Auladell, C., et al. (2017) · Molecular Neurobiology · doi:10.1007/s12035-017-0690-4 · Cited by 28

Optogenetic manipulation of astrocytes from synapses to neuronal networks: A potential therapeutic strategy for neurodegenerative diseases

Xie, Z., Yang, Q., Song, D. F., Quan, Z., & Qing, H. (2019) · Glia · doi:10.1002/glia.23693 · Cited by 31

Alternative splicing of neurexins 1–3 is modulated by neuroinflammation in the prefrontal cortex of a murine model of multiple sclerosis

Marchese, E., Valentini, M., Sante, G. D., Cesari, E., Adinolfi, A., Corvino, V., Ria, F., Sette, C., & Geloso, M. C. (2020) · Experimental Neurology · doi:10.1016/j.expneurol.2020.113497 · Cited by 33

The Effects of Incensole Acetate on Neuro-inflammation, Brain-Derived Neurotrophic Factor and Memory Impairment Induced by Lipopolysaccharide in Rats

Marefati, N., Beheshti, F., Vafaee, F., Barabadi, M., & Hosseini, M. (2021) · Neurochemical Research · doi:10.1007/s11064-021-03381-3 · Cited by 30

Nicotinic Acetylcholine Receptors and Microglia as Therapeutic and Imaging Targets in Alzheimer’s Disease

Takata, K., Kimura, H., Yanagisawa, D., Harada, K., Nishimura, K., Kitamura, Y., Shimohama, S., & Tooyama, I. (2022) · Molecules · doi:10.3390/molecules27092780 · Cited by 29

Evaluation of alexithymia in patients affected by rheumatoid arthritis and psoriatic arthritis

Chimenti, M. S., Fonti, G. L., Conigliaro, P., Hitaj, J., Triggianese, P., Teoli, M., Galluzzo, M., Talamonti, M., Kroegler, B., Greco, E., et al. (2019) · Medicine · doi:10.1097/md.0000000000013955 · Cited by 28

Baicalein Delays H 2 O 2 -Induced Astrocytic Senescence through Inhibition of Senescence-Associated Secretory Phenotype (SASP), Suppression of JAK2/STAT1/NF-κB Pathway, and Regulation of Leucine Metabolism

Gao, L., Zheng, W.-G., Wu, X., Du, G., & Qin, X. (2021) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.1c00024 · Cited by 27

Astrocyte control of the entorhinal cortex‐dentate gyrus circuit: Relevance to cognitive processing and impairment in pathology

Castro, M. A. D., & Volterra, A. (2021) · Glia · doi:10.1002/glia.24128 · Cited by 27

Elevated TNF-α Leads to Neural Circuit Instability in the Absence of Interferon Regulatory Factor 8

Feinberg, P. A., Becker, S. C., Chung, L., Ferrari, L. L., Stellwagen, D., Anaclet, C., Durán‐Laforet, V., Faust, T. E., Sumbria, R. K., & Schafer, D. P. (2022) · Journal of Neuroscience · doi:10.1523/jneurosci.0601-22.2022 · Cited by 28

Adeno-associated virus (AAV) 9-mediated gene delivery of Nurr1 and Foxa2 ameliorates symptoms and pathologies of Alzheimer disease model mice by suppressing neuro-inflammation and glial pathology

Yang, Y., Seok, M., Kim, Y. E., Choi, Y., Song, J., Sulistio, Y. A., Kim, S., Chang, M., Oh, S., Nam, M., et al. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01693-6 · Cited by 30

Elamipretide (SS-31) Improves Functional Connectivity in Hippocampus and Other Related Regions Following Prolonged Neuroinflammation Induced by Lipopolysaccharide in Aged Rats

Liu, Y., Fu, H., Wu, Y., Nie, B., Liu, F., Wang, T., Xiao, W. L., Yang, S., Kan, M., & Fan, L. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.600484 · Cited by 28

Astrocytes as Drivers and Disruptors of Behavior: New Advances in Basic Mechanisms and Therapeutic Targeting

Barnett, D., Bohmbach, K., Grelot, V., Charlet, A., Dallérac, G. M., Ju, Y. H., Nagai, J., & Orr, A. G. (2023) · Journal of Neuroscience · doi:10.1523/jneurosci.1376-23.2023 · Cited by 27

Microglial activation and neuroinflammation in acute and chronic cognitive deficits in sepsis

Denver, P., & Cunningham, C. M. (2024) · Neuropharmacology · doi:10.1016/j.neuropharm.2024.110285 · Cited by 33

Tumour Necrosis Factor in Neuroplasticity, Neurogenesis and Alcohol Use Disorder

Cooper, I. A., Beecher, K., Chehrehasa, F., Belmer, A., & Bartlett, S. E. (2020) · Brain Plasticity · doi:10.3233/bpl-190095 · Cited by 31

Anorexia induces a microglial associated pro-inflammatory environment and correlates with neurodegeneration in the prefrontal cortex of young female rats

Reyes-Ortega, P., Varman, D. R., Rodríguez, V. M., & Reyes‐Haro, D. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.112606 · Cited by 28

Preventing synaptic deficits in Alzheimer’s disease by inhibiting tumor necrosis factor alpha signaling

Cavanagh, C., & Wong, T. P. (2018) · IBRO Reports · doi:10.1016/j.ibror.2018.01.003 · Cited by 28

Anorexia increases microglial density and cytokine expression in the hippocampus of young female rats

Varman, D. R., Macedo-Mendoza, M., Labrada-Moncada, F. E., Reyes-Ortega, P., Morales, T., Martínez‐Torres, A., & Reyes‐Haro, D. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.01.042 · Cited by 26

Experimental autoimmune encephalopathy (EAE)-induced hippocampal neuroinflammation and memory deficits are prevented with the non-opioid TLR2/TLR4 antagonist (+)-naltrexone

Kwilasz, A. J., Todd, L. S., Duran-Malle, J. C., Schrama, A. E. W., Mitten, E. H., Larson, T. A., Clements, M. A., Harris, K. M., Litwiler, S. T., Wang, X., et al. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.112896 · Cited by 28

Neurodegenerative phagocytes mediate synaptic stripping in Neuro-HIV

Liberto, G. D., Égervári, K., Kreutzfeldt, M., Schürch, C. M., Hewer, E., Wagner, I., Pasquier, R. D., & Merkler, D. (2022) · Brain · doi:10.1093/brain/awac102 · Cited by 28

TNFα-Driven Astrocyte Purinergic Signaling during Epileptogenesis

Bedner, P., & Steinhäuser, C. (2018) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2018.12.001 · Cited by 25

Astrocytes Underlie Neuroinflammatory Memory Impairment

Osso, L. A., & Chan, J. R. (2015) · Cell · doi:10.1016/j.cell.2015.12.001 · Cited by 24

The protective effect of propofol against TNF-α-induced apoptosis was mediated via inhibiting iNOS/NO production and maintaining intracellular Ca2+ homeostasis in mouse hippocampal HT22 cells

Xu, Z., Lü, Y., Wang, J., Ding, X., Chen, J., & Miao, C. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.04.110 · Cited by 24

Hippocampal TNF-α Signaling Mediates Heroin Withdrawal-Enhanced Fear Learning and Withdrawal-Induced Weight Loss

Parekh, S. V., Paniccia, J. E., Adams, L. O., & Lysle, D. T. (2021) · Molecular Neurobiology · doi:10.1007/s12035-021-02322-z · Cited by 24

Dopamine Transmission Imbalance in Neuroinflammation: Perspectives on Long-Term COVID-19

Mancini, M., Natoli, S., Gardoni, F., Luca, M. D., & Pisani, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065618 · Cited by 24

NMDARs Adapt to Neurotoxic HIV Protein Tat Downstream of a GluN2A–Ubiquitin Ligase Signaling Pathway

Green, M. V., & Thayer, S. A. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.2980-16.2016 · Cited by 24

Heterogeneity and function of hippocampal macroglia

Seifert, G., & Steinhäuser, C. (2017) · Cell and Tissue Research · doi:10.1007/s00441-017-2746-1 · Cited by 25

Changes in neurosteroidogenesis during demyelination and remyelination in cuprizone‐treated mice

Leicaj, M. L., Pasquini, L. A., Lima, A. E., Deniselle, M. C. G., Pasquini, J. M., Nicola, A. F. D., & Garay, L. I. (2018) · Journal of Neuroendocrinology · doi:10.1111/jne.12649 · Cited by 26

Fragile X mental retardation protein protects against tumour necrosis factor-mediated cell death and liver injury

Zhuang, Y., Xu, H. C., Shinde, P. V., Warfsmann, J., Vasiļevska, J., Sundaram, B., Behnke, K., Huang, J., Hoell, J. I., Borkhardt, A., et al. (2019) · Gut · doi:10.1136/gutjnl-2019-318215 · Cited by 24

Advances in Potential Cerebrospinal Fluid Biomarkers for Autoimmune Encephalitis: A Review

Zhang, S., Mao, C., Li, X., Miao, W., & Teng, J. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.746653 · Cited by 23

A Microfluidic Human Model of Blood–Brain Barrier Employing Primary Human Astrocytes

Lauranzano, E., Campo, E., Rasile, M., Molteni, R., Pizzocri, M., Passoni, L., Bello, L., Pozzi, D., Pardi, R., Matteoli, M., et al. (2019) · Advanced Biosystems · doi:10.1002/adbi.201800335 · Cited by 23

Transient neonatal sleep fragmentation results in long-term neuroinflammation and cognitive impairment in a rabbit model

Bertrand, S. J., Zhang, Z., Patel, R. V., O'Ferrell, C., Punjabi, N. M., Kudchadkar, S. R., & Kannan, S. (2020) · Experimental Neurology · doi:10.1016/j.expneurol.2020.113212 · Cited by 24

A Review on Chronic Pain in Rheumatoid Arthritis: A Focus on Activation of NR2B Subunit of N-Methyl-D-Aspartate Receptors

Noh, A. S. M., & Ismail, C. A. N. (2020) · Malaysian Journal of Medical Sciences · doi:10.21315/mjms2020.27.1.2 · Cited by 23

Betaine Alleviates Cognitive Deficits in Diabetic Rats via PI3K/Akt Signaling Pathway Regulation

Huang, B., Hu, X., Hu, J., Chen, Z., & Zhao, H. (2020) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000508624 · Cited by 22

Stellate Ganglion Block Improves Postoperative Cognitive Dysfunction in aged rats by SIRT1-mediated White Matter Lesion Repair

Zhang, J., Liu, Y., Li, H., Hu, Y., Yu, S., Liu, Q., & Chen, Y. (2022) · Neurochemical Research · doi:10.1007/s11064-022-03800-z · Cited by 22

From adolescence to late aging: A comprehensive review of social behavior, alcohol, and neuroinflammation across the lifespan

Perkins, A. E., Varlinskaya, E. I., & Deak, T. (2019) · International review of neurobiology · doi:10.1016/bs.irn.2019.08.001 · Cited by 23

Immunity impacts cognitive deficits across neurological disorders

Shaw, B. C., Anders, V., Tinkey, R. A., Habean, M. L., Brock, O. D., Frostino, B. J., & Williams, J. L. (2023) · Journal of Neurochemistry · doi:10.1111/jnc.15999 · Cited by 27

What Is the Role of Cytokines in Synaptic Transmission?

Benarroch, E. E. (2024) · Neurology · doi:10.1212/wnl.0000000000209928 · Cited by 21

Functional changes in hippocampal synaptic signaling in offspring survivors of a mouse model of intrauterine inflammation

Kelley, M. H., Wu, W., Lei, J., McLane, M., Xie, H., Hart, K. D., Pereira, L. M., Burd, I. D., & Maylie, J. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0951-1 · Cited by 21

Neuroimmune multi-hit perspective of coronaviral infection

Hayley, S. P., & Sun, H. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02282-0 · Cited by 21

ADAR1 prevents ZBP1-dependent PANoptosis via A-to-I RNA editing in developmental sevoflurane neurotoxicity

Yang, H., Xu, S., Hong, X., Liu, Y., Qian, S., Lou, Y., & Wang, W. (2024) · Cell Biology and Toxicology · doi:10.1007/s10565-024-09905-1 · Cited by 20

Bioactive Foods Decrease Liver and Brain Alterations Induced by a High-Fat-Sucrose Diet through Restoration of Gut Microbiota and Antioxidant Enzymes

Syeda, T., Sánchez‐Tapia, M., Orta, I., Granados‐Portillo, O., Pérez-Jimenez, L., Rodríguez-Callejas, J. D., Toribio, S., Silva‐Lucero, M., Rivera, A. L., Tovar, A. R., et al. (2021) · Nutrients · doi:10.3390/nu14010022 · Cited by 20

Activation of SIRT-1 Pathway by Nanoceria Sheds Light on Its Ameliorative Effect on Doxorubicin-Induced Cognitive Impairment (Chemobrain): Restraining Its Neuroinflammation, Synaptic Dysplasticity and Apoptosis

Taha, M., Elazab, S. T., Badawy, A. M., Saati, A. A., Qusty, N. F., Al-Kushi, A. G., Sarhan, A. A., Osman, A., & Farage, A. E. (2022) · Pharmaceuticals · doi:10.3390/ph15080918 · Cited by 20

The Immuno-Glial Connectome in Alzheimer’s Disease: Integrating Central and Peripheral Inflammatory Networks

Gopalakrishna, P. K., Nassir, C. M. N. C. M., Anandan, S., Hussan, F., Dandala, K. C. R., Sura, S., Jagadeesan, S., Moklas, M. A. M., Vishnumukkala, T., & Hein, Z. M. (2026) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-026-01671-4 · Cited by 23

Effect of tumor necrosis factor-α on the expression of the ammonia transporter Rhcg in the brain in mice with acute liver failure

Wang, W., Lu, H., Xu, L., Wang, D., Wang, Z., Dai, W., Wang, J., & Liu, P. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1264-8 · Cited by 19

Immune-Triggered Forms of Plasticity Across Brain Regions

Hikosaka, M., Kawano, T., Wada, Y., Maeda, T., Sakurai, T., & Ohtsuki, G. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.925493 · Cited by 21

Stimulations of the Culture Medium of Activated Microglia and TNF-Alpha on a Scrapie-Infected Cell Line Decrease the Cell Viability and Induce Marked Necroptosis That Also Occurs in the Brains from the Patients of Human Prion Diseases

Ma, Y., Shi, Q., Xiao, K., Wang, J., Chen, C., Gao, L., Gao, C., & Dong, X. (2018) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.8b00354 · Cited by 20

Monitoring and Modulating Inflammation-Associated Alterations in Synaptic Plasticity: Role of Brain Stimulation and the Blood–Brain Interface

Lenz, M., Eichler, A., & Vlachos, A. (2021) · Biomolecules · doi:10.3390/biom11030359 · Cited by 19

The Duality of Astrocyte Neuromodulation: Astrocytes Sense Neuromodulators and Are Neuromodulators

Lines, J., Corkrum, M., Aguilar, J., & Araque, A. (2025) · Journal of Neurochemistry · doi:10.1111/jnc.70054 · Cited by 19

Different Mechanisms in Doxorubicin-Induced Neurotoxicity: Impact of BRCA Mutations

Bhatt, K. S., Singh, A., Marwaha, G. S., Ravendranathan, N., Sandhu, I. S., Kim, K., Singh, E., Frisbee, J. C., & Singh, K. K. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26104736 · Cited by 18

Astroglial adrenoreceptors modulate synaptic transmission and contextual fear memory formation in dentate gyrus

Shen, W., Chen, S., Xiang, Y., Yao, Z., Chen, Z., Wu, X., Li, L., & Zeng, L. (2020) · Neurochemistry International · doi:10.1016/j.neuint.2020.104942 · Cited by 18

Early Changes in Exo- and Endocytosis in the EAE Mouse Model of Multiple Sclerosis Correlate with Decreased Synaptic Ribbon Size and Reduced Ribbon-Associated Vesicle Pools in Rod Photoreceptor Synapses

Kesharwani, A., Schwarz, K., Dembla, E., Dembla, M., & Schmitz, F. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910789 · Cited by 16

Z-DNA/RNA Binding Protein 1 Senses Mitochondrial DNA to Induce Receptor-Interacting Protein Kinase-3/Mixed Lineage Kinase Domain-Like-Driven Necroptosis in Developmental Sevoflurane Neurotoxicity

Wang, W., Yi, W.-Q., Liu, Y., Hu, Q., Qian, S., Liu, J., Mao, H. Z., Cai, F., & Yang, H. (2022) · Neuroscience · doi:10.1016/j.neuroscience.2022.11.005 · Cited by 18

Postmortem Brains from Subjects with Diabetes Mellitus Display Reduced GLUT4 Expression and Soma Area in Hippocampal Neurons: Potential Involvement of Inflammation

Yonamine, C. Y., Passarelli, M., Suemoto, C. K., Pasqualucci, C. A., Filho, W. J., Alves, V. A. F., Marie, S. K. N., Corrêa‐Giannella, M. L., Britto, L. R., & Machado, U. F. (2023) · Cells · doi:10.3390/cells12091250 · Cited by 18

Autoimmune inflammation triggers aberrant astrocytic calcium signaling to impair synaptic plasticity

Baraibar, A. M., Colomer, T., Moreno‐García, A., Bernal‐Chico, A., Sánchez-Martín, E., Utrilla, C., Serrat, R., Gómez, E. S., Rodríguez-Antigüedad, A., Araque, A., et al. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.07.010 · Cited by 18

Distinct cytokine profiles across trajectories of self-perceived cognitive impairment among early-stage breast cancer survivors

Toh, Y. L., Wang, C., Ho, H. K., & Chan, A. (2020) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2020.577196 · Cited by 18

Disturbed Presynaptic Ca2+ Signaling in Photoreceptors in the EAE Mouse Model of Multiple Sclerosis

Mukherjee, A., Katiyar, R., Dembla, E., Dembla, M., Kumar, P., Belkacemi, A., Jung, M., Beck, A., Flockerzi, V., Schwarz, K., et al. (2020) · iScience · doi:10.1016/j.isci.2020.101830 · Cited by 16

Early Transcriptional Changes in Rabies Virus-Infected Neurons and Their Impact on Neuronal Functions

Kim, S., Larrous, F., Varet, H., Legendre, R., Feige, L., Dumas, G., Matsas, R., Kouroupi, G., Grailhe, R., & Bourhy, H. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.730892 · Cited by 17

Insights into Human-Induced Pluripotent Stem Cell-Derived Astrocytes in Neurodegenerative Disorders

Kumar, M., Nguyen, T. P. N., Milanese, M., & Bonanno, G. (2022) · Biomolecules · doi:10.3390/biom12030344 · Cited by 20

Astrocytic purinergic signalling contributes to the development and maintenance of neuropathic pain via modulation of glutamate release

Liu, S., Cheng, H., Cui, L., Jin, L., Li, Y., Zhu, C., Ji, Q., & Tang, J. (2023) · Journal of Neurochemistry · doi:10.1111/jnc.15800 · Cited by 17

Therapeutic Potential of Astrocyte Purinergic Signalling in Epilepsy and Multiple Sclerosis

Nobili, P., Shen, W., Milicevic, K. D., Pristov, J. B., Audinat, É., & Nikolic, L. M. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.900337 · Cited by 17

The neurovascular basis of processing speed differences in humans: A model-systems approach using multiple sclerosis

Sivakolundu, D. K., West, K. L., Zuppichini, M. D., Turner, M. P., Abdelkarim, D., Zhao, Y., Spence, J. S., Lu, H., Okuda, D. T., & Rypma, B. (2020) · NeuroImage · doi:10.1016/j.neuroimage.2020.116812 · Cited by 16

Effects of a six-month yoga intervention on the immune-inflammatory pathway in antipsychotic-stabilized schizophrenia patients: A randomized controlled trial

Mullapudi, T., Debnath, M., Govindaraj, R., Raj, P., Banerjee, M., & Varambally, S. S. (2023) · Asian Journal of Psychiatry · doi:10.1016/j.ajp.2023.103636 · Cited by 16

Tumor necrosis factor‐alpha −1031T/C polymorphism is associated with cognitive deficits in chronic schizophrenia patients versus healthy controls

Xiu, M. H., Man, L., Wang, D., Du, X., Yin, G., Zhang, Y., Tan, Y., Chen, N., Chen, S., Teixeira, A. L., et al. (2018) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32622 · Cited by 16

Neurodegenerative disease treatments by direct TNF reduction, SB623 cells, maraviroc and irisin and MCC950, from an inflammatory perspective – a Commentary

Clark, I. A., & Vissel, B. (2019) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2019.1618710 · Cited by 16

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Srivastava, I., Vázquez‐Juárez, E., & Lindskog, M. (2020) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2020.00037 · Cited by 16

Microglia-triggered hypoexcitability plasticity of pyramidal neurons in the rat medial prefrontal cortex

Yamawaki, Y., Wada, Y., Matsui, S., & Ohtsuki, G. (2022) · Current Research in Neurobiology · doi:10.1016/j.crneur.2022.100028 · Cited by 16

The influence of sleep disorders on perioperative neurocognitive disorders among the elderly: A narrative review

Chen, C., Zhai, R., Lan, X., Yang, S., Tang, S., Xiong, X., He, Y., Lin, J., Feng, J., Chen, D., et al. (2024) · Ibrain · doi:10.1002/ibra.12167 · Cited by 15

Pathology of the neurovascular unit in leukodystrophies

Zarekiani, P., Breur, M., Wolf, N. I., de Vries, H. E., van der Knaap, M. S., & Bugiani, M. (2021) · Acta Neuropathologica Communications · doi:10.1186/s40478-021-01206-6 · Cited by 16

Exploring Astrocyte-Mediated Mechanisms in Sleep Disorders and Comorbidity

Li, Y., Que, M., Wang, X., Zhan, G., Zhou, Z., Luo, X., & Li, S. (2023) · Biomedicines · doi:10.3390/biomedicines11092476 · Cited by 18

Gliotransmitter Exocytosis and Its Consequences on Synaptic Transmission

Pittà, M. D. (2019) · Springer series in computational neuroscience · doi:10.1007/978-3-030-00817-8_10 · Cited by 15

Targeting TNFα produced by astrocytes expressing amyotrophic lateral sclerosis‐linked mutant fused in sarcoma prevents neurodegeneration and motor dysfunction in mice

Jensen, B. K., McAvoy, K. J., Heinsinger, N. M., Lepore, A. C., Ilieva, H. S., Haeusler, A. R., Trotti, D., & Pasinelli, P. (2022) · Glia · doi:10.1002/glia.24183 · Cited by 14

Mechanism of lily bulb and Rehmannia decoction in the treatment of lipopolysaccharide-induced depression-like rats based on metabolomics study and network pharmacology

Chi, X., Xue, X., Pan, J., Wu, J., Shi, H., Wang, Y., Lu, Y., Zhang, Z., & Ma, K. (2022) · Pharmaceutical Biology · doi:10.1080/13880209.2022.2121843 · Cited by 16

TNFα induced up-regulation of Na+,K+,2Cl− cotransporter NKCC1 in hepatic ammonia clearance and cerebral ammonia toxicity

Pozdeev, V. I., Lang, E., Görg, B., Bidmon, H. J., Shinde, P. V., KIRCHEIS, G., Herebıan, D., Pfeffer, K., Lang, F. J. W., Häussinger, D., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-07640-8 · Cited by 16

Astrocytes Underlie Neuroinflammatory Memory Impairment

Osso, L. A., & Chan, J. R. (2015) · Cell · doi:10.1016/j.cell.2015.12.001 · Cited by 24

Impairing cognition with TNF-α

Gough, N. R. (2016) · Science Signaling · doi:10.1126/scisignal.aaf1771 · Cited by 2

Astrocytic tumour necrosis factor underlies neuron function in cognition

Anscomb, H., & Baune, B. (2010) · ResearchOnline at James Cook University (James Cook University)

Astrocyte control of the entorhinal cortex‐dentate gyrus circuit: Relevance to cognitive processing and impairment in pathology

Castro, M. A. D., & Volterra, A. (2021) · Glia · doi:10.1002/glia.24128 · Cited by 27

Deletion of TNFR1 in astrocytes restores memory in aged Alzheimer’s disease micePreprint

Kikuchi, T., Zalachoras, I., Prados, J., Assens, A., Ceglia, R. D., Mameli, M., Telley, L., & Volterra, A. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.04.02.716130