Cited by 348Neuroinflammation and Neurodegeneration MechanismsNeuroscience and Neuropharmacology ResearchTryptophan and brain disorders

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Neuroinflammatory TNFα Impairs Memory via Astrocyte Signaling

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Habbas, Samia, Santello, Mirko, Becker, Denise, Stubbe, Hiltrud, Zappia, Giovanna, Liaudet, Nicolas, Klaus, Federica R., Kollias, George, Fontana, Adriano, Pryce, Christopher R., Suter, Tobias, Volterra, Andrea·2015·Cell

DOI 10.1016/j.cell.2015.11.023

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Abstract

The occurrence of cognitive disturbances upon CNS inflammation or infection has been correlated with increased levels of the cytokine tumor necrosis factor-α (TNFα). To date, however, no specific mechanism via which this cytokine could alter cognitive circuits has been demonstrated. Here, we show that local increase of TNFα in the hippocampal dentate gyrus activates astrocyte TNF receptor type 1 (TNFR1), which in turn triggers an astrocyte-neuron signaling cascade that results in persistent functional modification of hippocampal excitatory synapses. Astrocytic TNFR1 signaling is necessary for the hippocampal synaptic alteration and contextual learning-memory impairment observed in experimental autoimmune encephalitis (EAE), an animal model of multiple sclerosis (MS). This process may contribute to the pathogenesis of cognitive disturbances in MS, as well as in other CNS conditions accompanied by inflammatory states or infections.

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Srinivas, S., Watanabe, T., Lin, C.-S., William, C. M., Tanabe, Y., Jessell, T. M., & Costantini, F. (2001) · BMC Developmental Biology · doi:10.1186/1471-213x-1-4 · Cited by 3,121
NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease
Paoletti, P., Bellone, C., & Zhou, Q. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3504 · Cited by 2,523
Cognitive impairment in multiple sclerosis
Chiaravalloti, N. D., & DeLuca, J. (2008) · The Lancet Neurology · doi:10.1016/s1474-4422(08)70259-x · Cited by 2,088
Astrocyte-Neuron Lactate Transport Is Required for Long-Term Memory Formation
Suzuki, A., Stern, S. A., Bozdagi, O., Huntley, G. W., Walker, R. H., Magistretti, P. J., & Alberini, C. M. (2011) · Cell · doi:10.1016/j.cell.2011.02.018 · Cited by 1,711
Optogenetic stimulation of a hippocampal engram activates fear memory recall
Liu, X., Ramirez, S., Pang, P. T., Puryear, C. B., Govindarajan, A., Deisseroth, K. A., & Tonegawa, S. (2012) · Nature · doi:10.1038/nature11028 · Cited by 1,669
Immune modulation of learning, memory, neural plasticity and neurogenesis
Yirmiya, R., & Goshen, I. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2010.10.015 · Cited by 1,483
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Beattie, E. C., Stellwagen, D., Morishita, W., Bresnahan, J. C., Ha, B. K., Von Zastrow, M., Beattie, M. S., & Malenka, R. C. (2002) · Science · doi:10.1126/science.1067859 · Cited by 1,344
Gliotransmitters Travel in Time and Space
Araque, A., Carmignoto, G., Haydon, P. G., Oliet, S. H. R., Robitaille, R., & Volterra, A. (2014) · Neuron · doi:10.1016/j.neuron.2014.02.007 · Cited by 1,308
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Pascual, O., Casper, K. B., Kubera, C., Zhang, J., Revilla-Sanchez, R., Sul, J.-Y., Takano, H., Moss, S. J., McCarthy, K., & Haydon, P. G. (2005) · Science · doi:10.1126/science.1116916 · Cited by 1,280
Mice lacking the tumour necrosis factor receptor 1 are resistant to IMF-mediated toxicity but highly susceptible to infection by Listeria monocytogenes
Rothe, J., Lesslauer, W., Loetscher, H., Lang, Y., Koebel, P., Köntgen, F., Althage, A., Zinkernagel, R. M., Steinmetz, M., & Bluethmann, H. (1993) · Nature · doi:10.1038/364798a0 · Cited by 1,246

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Al-Ardi, M. H. (2021) · Mağallaẗ ʻulūm al-rāfidayn · doi:10.33899/rjs.2021.167679 · Cited by 4
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González-Arias, C., & Perea, G. (2019) · Springer series in computational neuroscience · doi:10.1007/978-3-030-00817-8_8 · Cited by 4
Microglial activation results in neuron-type-specific increase in mPFC GABAergic transmission and abnormal behavior in micePreprint
Tang, B., Jiang, J., Wang, L., Misrani, A. A., Huo, Q., Han, Y., Long, C., & Yang, L. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.06.13.149906 · Cited by 4
Pathogenesis of HIV-associated depression: contributing factors and underlying mechanisms
Zaongo, S. D., Wu, W. K., & Chen, Y.-K. (2025) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2025.1557816 · Cited by 6
Midbrain microglial and macrophage mRNAs distinguish neuroinflammatory schizophrenia from bipolar disorder
Victoriano, G. M., Zhu, Y., Kostoglou, Y., Walker, A. K., Middleton, F. A., Massa, P. T., Eggen, B. J. L., Webster, M. J., Sommer, I. E., & Weickert, C. S. (2026) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2026.106276 · Cited by 5
Glioinflammation: disease-associated microglia and astrocytes in psychiatric disorders, neurodegeneration, and senescence
Uemura, K., Hiro, S., Attachaipanich, S., Du, R., Yusof, N. I. S. M., Kinoshita, M., Hikosaka, M., & Ohtsuki, G. (2026) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2025.1669272 · Cited by 5
TNF-α and IFN-γ impair neural oscillations and induce neurodegeneration by microglial nitric oxide, metabolic and oxidative stress
Malorny, N., Chausse, B., Khodaie, B., Elgez, A., Söder, L., Lewen, A., Egorov, A. V., & Kann, O. (2026) · Journal of Neuroinflammation · doi:10.1186/s12974-026-03835-x · Cited by 3
α-Bisabolol alleviates doxorubicin-induced cognitive dysfunction in rats via enhancing the hippocampal BDNF/TrKB signaling and inhibiting neuroinflammation
Elazab, S. T., & Hsu, W. H. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1549009 · Cited by 3
Neuro-immune interactions in memory
Stewart, E., & Ryan, T. J. (2025) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2025.108077 · Cited by 3
Characterization of soticlestat, a novel cholesterol 24-hydroxylase inhibitor, in acute and chronic neurodegeneration models
Hasegawa, S., Watanabe, S., Fujimoto, S., Kondo, S., & Nishi, T. (2024) · Neuroscience Research · doi:10.1016/j.neures.2024.06.005 · Cited by 3
CD8 positive T-cells decrease neurogenesis and induce anxiety-like behaviour following hepatitis B vaccination
Zhou, T., Gao, Y., Wang, Z., Dai, C., Lei, M., Liew, A. Y., Yan, S., Yao, Z., Hu, D., & Qi, F. (2024) · Brain Communications · doi:10.1093/braincomms/fcae315 · Cited by 4
State-of-art modelling of inflammatory astrocyte-synapse interactions in injury and amyotrophic lateral sclerosis
Lakatos, A. (2017) · Neural Regeneration Research · doi:10.4103/1673-5374.198977 · Cited by 3
Pathologie und Pathogenese der progredienten Multiplen Sklerose: Konzepte und Kontroversen
Schumacher, A.-M., Mahler, C. F., & Kerschensteiner, M. (2017) · Aktuelle Neurologie · doi:10.1055/s-0043-106736 · Cited by 3
Memory loss induced by lisdexamfetamine in the rat: A behavioral, electrophysiological, and histopathological Study
Nourirad, S. N., Bayat, A., Sani, M. H., Beirami, A. D., Hasanzadeh, M., Roustaee, S., Fathi, M., Vakili, K. G., Parvardeh, S., Meftahi, G. H., et al. (2024) · Behavioural Brain Research · doi:10.1016/j.bbr.2024.114963 · Cited by 2
Beta-lactam Antibiotic Cefepime Attenuates Lipopolysaccharide-induced Pain and Depression By Modulating Inflammatory Response and Astroglial Glutamate Transporter in Mice
Khan, A., Ronan, P. J., & Rahman, S. (2026) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-026-10279-w · Cited by 4
Evaluation of delayed LNFPIII treatment initiation protocol on improving long-term behavioral and neuroinflammatory pathology in a mouse model of Gulf War Illness
Carpenter, J. M., Brown, K. A., Veltmaat, L., Ludwig, H. D., Clay, K. B., Norberg, T., Harn, D. A., Wagner, J. J., & Filipov, N. M. (2022) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2022.100553 · Cited by 3
Tumor necrosis factor α modulates excitatory and inhibitory neurotransmission in a concentration-dependent mannerPreprint
Kleidonas, D., Kirsch, M., Andrieux, G., Pfeifer, D., Boerries, M., & Vlachos, A. (2022) · bioRxiv · doi:10.1101/2022.04.14.487444 · Cited by 2
Chronic activation of astrocytic G q GPCR signaling has causal effects on visual LTP formation: implications for neurodegenerative diseasesPreprint
Moukarzel, E., Antoine, S., Guinoiseau, S., Rubino, B., Stinnakre, J., & Agulhon, C. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.04.16.589763 · Cited by 2
Extracellular vesicles released by ALL patients contain HNE-adducted proteins: Implications of collateral damage
Ho, J., Sukati, S., Taylor, T. J., Carter, S., Fuller, B. L., Marmo, A., Sorge, C. E., D'Orazio, J. A., Butterfield, D. A., Bondada, S., et al. (2024) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2024.12.006 · Cited by 1
Probiotic supplementation attenuates dental pain and inhibits pain-induced cognitive impairment in male rats
Abazari-Bozhgani, P., Esmaeili‐Mahani, S., Abbasnejad, M., Raoof, M., & Lobbezoo, F. (2025) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2025.106382 · Cited by 1
Transregional astrocyte-dependent metaplasticity in the hippocampus
Sateesh, S., Logan, B. J., Suzuki, M., Stellwagen, D., & Abraham, W. C. (2026) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2536065123 · Cited by 1
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Sarkar, S., Guha, S., & Biswas, S. C. (2022) · Springer eBooks · doi:10.1007/978-981-16-8313-8_9 · Cited by 1
Mysteries and Miseries of Creativity
(2016) · Cell · doi:10.1016/j.cell.2016.01.016 · Cited by 1
Methyl vinyl ketone impairs spatial memory and activates hippocampal glial cells in mice
Sato, R. Y., Kotake, K. T., Zhang, Y., Onishi, H., Matsui, F., Norimoto, H., & Zhou, Z. (2023) · PLoS ONE · doi:10.1371/journal.pone.0289714 · Cited by 1
In conversation with Andrea Volterra
Floriddia, E. (2024) · Nature Neuroscience · doi:10.1038/s41593-024-01721-4 · Cited by 1
Spineless Behavior of CX3CR1+ Monocytes in Response to Infection
Muller, P. A., & Mucida, D. (2017) · Immunity · doi:10.1016/j.immuni.2017.06.022 · Cited by 1
Microglia-triggered hyperexcitability in the cerebellum depresses animal behaviorsPreprint
Yamamoto, M., Kim, M., Imai, H., & Ohtsuki, G. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/353730 · Cited by 1
Glutamatergic and Neuroimmune Mechanisms of N-acetylcysteine-Mediated Inhibition of Cue-Induced Nicotine Seeking
Namba, M. D. (2019) · Cited by 1
Astrocyte Ca 2+ signalling mediates long-distance metaplasticity in the hippocampal CA1Preprint
Jones, O. D., Singh, A., Logan, B. J., & Abraham, W. C. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.06.19.545623 · Cited by 1
Chronic IL-1-induced DNA double-strand break response in hippocampal neurons drives cognitive deficitsPreprint
Belloy, M., Schmitt, B. A. M., Marty, F. H., Paut, C., Emilie, B.-P., Aïda, A., Alis, M., Ecalard, R., Boursereau, R., Gonzalez‐Dunia, D., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.02.03.578747 · Cited by 1
Roles of dopaminergic systems and inflammation-related molecules derived from microglia in stress-induced behavioral changes
Shinohara, R., Kitaoka, S., & Furuyashiki, T. (2016) · PAIN RESEARCH · doi:10.11154/pain.31.1
Reactive astrocytes - comprehending when neurons play 4’33”Preprint
Volman, V., & Bazhenov, M. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/189134
Neuroimmunopharmacology at the Interface of Inflammation and Pharmacology Relevant to Depression
Holmes, J., Corrigan, F., & Hutchinson, M. R. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-811073-7.00012-x
Brain region-dependent alterations in polysialic acid immunoreactivity across the estrous cycle in mice
Giacometti, L. L., Huang, F., Hamilton, B. S., & Barker, J. M. (2020) · Hormones and Behavior · doi:10.1016/j.yhbeh.2020.104851

Authors: Habbas, S., Santello, M., Becker, D., Stubbe, H., Zappia, G., Liaudet, N., Klaus, F. R., Kollias, G., Fontana, A., Pryce, C. R., Suter, T., & Volterra, A.
Affiliations: University of Lausanne (CH)
University of Zurich (CH)
Alexander Fleming Biomedical Sciences Research Center (GR)
University Hospital Zurich (CH)
Corresponding author: Volterra, Andrea
ORCID: Santello, Mirko
Becker, Denise
Liaudet, Nicolas
Klaus, Federica R.
Kollias, George
Pryce, Christopher R.
Suter, Tobias
Volterra, Andrea
Venue: Cell
Publisher: Elsevier BV
Published: 2015-12
Volume: 163
Issue: 7
Pages: 1730-1741
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/j.cell.2015.11.023
OpenAlex: W2190725993
Cited by: 347
References: 52
Citations by year: 2026: 25 · 2025: 28 · 2024: 28 · 2023: 31 · 2022: 43 · 2021: 42 · 2020: 35 · 2019: 41 · 2018: 30 · 2017: 29 · 2016: 14 · 2015: 1
FWCI: 13.15
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 382 d)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, cc-by-nc)
SERVAL (Université de Lausanne) (acceptedVersion, other-oa)
Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
Bern Open Repository and Information System (University of Bern) (submittedVersion)
IRIS (submittedVersion)
Zurich Open Repository and Archive (University of Zurich) (submittedVersion, cc-by-nc)
Zurich Open Repository and Archive (University of Zurich)
Funders: National Science Foundation
Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (140999, 141137, 31003A)
Université de Lausanne
Universität Zürich
Topics: Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords: TNF-α, TNFR1, astrocytes, astrocyte-neuron communication, hippocampus, dentate gyrus, synaptic plasticity, memory impairment, contextual learning, experimental autoimmune encephalitis, multiple sclerosis, neuroinflammation, cognitive impairment
MeSH terms: Animals, Astrocytes, Encephalomyelitis, Autoimmune, Experimental, Humans, Learning, Memory, Multiple Sclerosis, Piperidines, Tumor Necrosis Factor-alpha, Signal Transduction, Receptors, N-Methyl-D-Aspartate, Dentate Gyrus, Receptors, Tumor Necrosis Factor, Type I, Mice

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Neuroinflammatory TNFα Impairs Memory via Astrocyte Signaling

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