The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.
Force Feedback Controls Motor Activity and Mechanical Properties of Self-Assembling Branched Actin Networks
Open accessAbstract
Branched actin networks–created by the Arp2/3 complex, capping protein, and a nucleation promoting factor– generate and transmit forces required for many cellular processes, but their response to force is poorly understood. To address this, we assembled branched actin networks in vitro from purified components and used simultaneous fluorescence and atomic force microscopy to quantify their molecular composition and material properties under various forces. Remarkably, mechanical loading of these self-assembling materials increases their density, power, and efficiency. Microscopically, increased density reflects increased filament number and altered geometry, but no change in average length. Macroscopically, increased density enhances network stiffness and resistance to mechanical failure beyond those of isotropic actin networks. These effects endow branched actin networks with memory of their mechanical history that shapes their material properties and motor activity. This work reveals intrinsic force feedback mechanisms by which mechanical resistance makes self-assembling actin networks stiffer, stronger, and more powerful.
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Extracellular fluid viscosity enhances cell migration and cancer dissemination
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Metadata
- Authors
- Bieling, P., Li, T.-D., Weichsel, J., McGorty, R., Jreij, P., Huang, B., Fletcher, D. A., & Mullins, R. D.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2016-01
- Volume
- 164
- Issue
- 1-2
- Pages
- 115-127
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2233203177
- Cited by
- 263
- References
- 50
- FWCI
- 17.21
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Force Feedback Controls Motor Activity and Mechanical Properties of Self-Assembling Branched Actin Networks. https://app.cochat.ai/papers/10.1016/j.cell.2015.11.057
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- Bieling, P., Li, T.-D., Weichsel, J., McGorty, R., Jreij, P., Huang, B., Fletcher, D. A., & Mullins, R. D. (2016). Force Feedback Controls Motor Activity and Mechanical Properties of Self-Assembling Branched Actin Networks. Cell. https://doi.org/10.1016/j.cell.2015.11.057
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
