The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Innate Lymphocyte/Ly6C hi Monocyte Crosstalk Promotes Klebsiella Pneumoniae Clearance
Open accessAbstract
SUMMARY Increasing antibiotic resistance among bacterial pathogens has rendered some infections untreatable with available antibiotics. Klebsiella pneumoniae, a bacterial pathogen that has acquired high-level antibiotic resistance, is a common cause of pulmonary infections. Optimal clearance of K. pneumoniae from the host lung requires TNF and IL-17A. Herein we demonstrate that inflammatory monocytes are rapidly recruited to the lungs of K. pneumoniae infected mice, and produce TNF, which markedly increases the frequency of IL-17-producing innate lymphoid cells. While pulmonary clearance of K. pneumoniae is preserved in neutrophil-depleted mice, monocyte depletion or TNF deficiency impairs IL-17A–dependent resolution of pneumonia. Monocyte-mediated bacterial uptake and killing is enhanced by ILC production of IL-17A, indicating that innate lymphocytes engage in a positive feedback loop with monocytes that promotes clearance of pneumonia. Innate immune defense against a highly antibiotic-resistant bacterial pathogen depends on crosstalk between inflammatory monocytes and innate lymphocytes that is mediated by TNF and IL-17A.
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Cites
Monocyte and macrophage heterogeneity
Gordon, S., & Taylor, P. R. (2005) · Nature Reviews Immunology · doi:10.1038/nri1733 · Cited by 5,190
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Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm
Biswas, S. K., & Mantovani, A. (2010) · Nature Immunology · doi:10.1038/ni.1937 · Cited by 3,840
Liang, S. C., Tan, X.-Y., Luxenberg, D. P., Karim, R., Dunussi-Joannopoulos, K., Collins, M., & Fouser, L. A. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20061308 · Cited by 2,330
Conti, H. R., Shen, F., Nayyar, N., Stocum, E., Sun, J. N., Lindemann, M. J., Ho, A. W., Hai, J. H., Yu, J. J., Jung, J. W., et al. (2009) · Journal of Experimental Medicine · doi:10.1084/jem.20081463 · Cited by 1,024 · cited 1×
“Our results suggest that TNF enhances ILC recruitment to the lung by upregulating the chemokine CCL20, which has been shown to be expressed by pulmonary epithelial cells, and its expression can be boosted by TNF and IL-17 (Conti et al., 2009; Hirota et al., 2007; Kao et al., 2005; Starner et al., 2003; Sugita et al.,…”
Microbiota-dependent crosstalk between macrophages and ILC3 promotes intestinal homeostasis
Mortha, A., Chudnovskiy, A., Hashimoto, D., Bogunovic, M., Spencer, S. P., Belkaid, Y., & Merad, M. (2014) · Science · doi:10.1126/science.1249288 · Cited by 820
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Ectopic colonization of oral bacteria in the intestine drives T H 1 cell induction and inflammation
Atarashi, K., Suda, W., Luo, C., Kawaguchi, T., Motoo, I., Narushima, S., Kiguchi, Y., Yasuma, K., Watanabe, E., Tanoue, T., et al. (2017) · Science · doi:10.1126/science.aan4526 · Cited by 957
Fatty Liver Disease Caused by High-Alcohol-Producing Klebsiella Pneumoniae
Yuan, J., Chen, C., Cui, J., Lu, J., Yan, C., Wei, X., Zhao, X., Li, N., Li, S., Xue, G., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.08.018 · Cited by 548
Baral, P., Umans, B. D., Li, L., Wallrapp, A., Bist, M., Kirschbaum, T., Wei, Y., Zhou, Y., Kuchroo, V. K., Burkett, P. R., et al. (2018) · Nature Medicine · doi:10.1038/nm.4501 · Cited by 422
Metadata
- Authors
- Xiong, H., Keith, J. W., Samilo, D. W., Carter, R. A., Leiner, I. M., & Pamer, E. G.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2016-04
- Volume
- 165
- Issue
- 3
- Pages
- 679-689
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2315845939
- Cited by
- 182
- References
- 6
- FWCI
- 12.45
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Xiong, H., Keith, J. W., Samilo, D. W., Carter, R. A., Leiner, I. M., & Pamer, E. G. (2016). Innate Lymphocyte/Ly6C hi Monocyte Crosstalk Promotes Klebsiella Pneumoniae Clearance. Cell. https://doi.org/10.1016/j.cell.2016.03.017
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
