The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
Nociceptor sensory neurons suppress neutrophil and γδ T cell responses in bacterial lung infections and lethal pneumonia
Open accessAbstract
Lung-innervating nociceptor sensory neurons detect noxious or harmful stimuli and consequently protect organisms by mediating coughing, pain, and bronchoconstriction. However, the role of sensory neurons in pulmonary host defense is unclear. Here, we found that TRPV1+ nociceptors suppressed protective immunity against lethal Staphylococcus aureus pneumonia. Targeted TRPV1+-neuron ablation increased survival, cytokine induction, and lung bacterial clearance. Nociceptors suppressed the recruitment and surveillance of neutrophils, and altered lung γδ T cell numbers, which are necessary for immunity. Vagal ganglia TRPV1+ afferents mediated immunosuppression through release of the neuropeptide calcitonin gene–related peptide (CGRP). Targeting neuroimmunological signaling may be an effective approach to treat lung infections and bacterial pneumonia.
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Neuromodulation by the immune system: a focus on cytokines
Salvador, A. F., de Lima, K. A., & Kipnis, J. (2021) · Nature Reviews Immunology · doi:10.1038/s41577-021-00508-z · Cited by 389
Cutaneous TRPV1+ Neurons Trigger Protective Innate Type 17 Anticipatory Immunity
Cohen, J. A., Edwards, T. N., Liu, A. W., Hirai, T., Jones, M. R., Wu, J., Li, Y., Zhang, S., Ho, J., Davis, B. M., et al. (2019) · Cell · doi:10.1016/j.cell.2019.06.022 · Cited by 371
Nociceptor neurons affect cancer immunosurveillance
Balood, M., Ahmadi, M., Eichwald, T., Ahmadi, A., Majdoubi, A., Roversi, K., Roversi, K., Lucido, C. T., Restaino, A. C., Huang, S., et al. (2022) · Nature · doi:10.1038/s41586-022-05374-w · Cited by 369
Internal senses of the vagus nerve
Prescott, S. L., & Liberles, S. D. (2022) · Neuron · doi:10.1016/j.neuron.2021.12.020 · Cited by 331
Self-citationNeuropeptide CGRP Limits Group 2 Innate Lymphoid Cell Responses and Constrains Type 2 Inflammation
Nagashima, H., Mahlakõiv, T., Shih, H.-Y., Davis, F. P., Meylan, F., Huang, Y., Harrison, O. J., Yao, C., Mikami, Y., Urban, J. F., et al. (2019) · Immunity · doi:10.1016/j.immuni.2019.06.009 · Cited by 322
Metadata
- Authors
- Baral, P., Umans, B. D., Li, L., Wallrapp, A., Bist, M., Kirschbaum, T., Wei, Y., Zhou, Y., Kuchroo, V. K., Burkett, P. R., Yipp, B. G., Liberles, S. D., & Chiu, I. M.
- Venue
- Nature Medicine
- Published
- 2018-03-05
- Volume
- 24
- Issue
- 4
- Pages
- 417-426
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W2791770850
- Cited by
- 422
- References
- 56
- FWCI
- 13.43
- Type
- journal article
- Language
- en
- Open access
- green
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- Baral, P., Umans, B. D., Li, L., Wallrapp, A., Bist, M., Kirschbaum, T., Wei, Y., Zhou, Y., Kuchroo, V. K., Burkett, P. R., Yipp, B. G., Liberles, S. D., & Chiu, I. M. (2018). Nociceptor sensory neurons suppress neutrophil and γδ T cell responses in bacterial lung infections and lethal pneumonia. Nature Medicine. https://doi.org/10.1038/nm.4501
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
