The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
RNA Duplex Map in Living Cells Reveals Higher-Order Transcriptome Structure
Open accessAbstract
SUMMARY RNA has the intrinsic property to base pair, forming complex structures fundamental to its diverse functions. Here we develop PARIS, a method based on reversible psoralen-crosslinking for global mapping of RNA duplexes with near base-pair resolution in living cells. PARIS analysis in three human and mouse cell types reveals frequent long-range structures, higher order architectures, and RNA:RNA interactions in trans across the transcriptome. PARIS determines base-pairing interactions on an individual-molecule level, revealing pervasive alternative conformations. We used PARIS-determined helices to guide phylogenetic analysis of RNA structures, and discovered conserved long-range and alternative structures. XIST, a lncRNA essential for X chromosome inactivation, folds into evolutionarily conserved RNA structural domains that span many kilobases. XIST A-repeat forms complex inter-repeat duplexes that nucleate higher order assembly of the key epigenetic silencing protein SPEN. PARIS is a generally applicable and versatile method that provides novel insights into the RNA structurome and interactome.
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Self-citationRNA sequencing: the teenage years
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Metadata
- Authors
- Lu, Z., Zhang, Q. C., Lee, B., Flynn, R. A., Smith, M. A., Robinson, J. T., Davidovich, C., Gooding, A. R., Goodrich, K. J., Mattick, J. S., Mesirov, J. P., Cech, T. R., & Chang, H. Y.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2016-05
- Volume
- 165
- Issue
- 5
- Pages
- 1267-1279
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2388201280
- Cited by
- 656
- References
- 45
- FWCI
- 32.50
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Lu, Z., Zhang, Q. C., Lee, B., Flynn, R. A., Smith, M. A., Robinson, J. T., Davidovich, C., Gooding, A. R., Goodrich, K. J., Mattick, J. S., Mesirov, J. P., Cech, T. R., & Chang, H. Y. (2016). RNA Duplex Map in Living Cells Reveals Higher-Order Transcriptome Structure. Cell. https://doi.org/10.1016/j.cell.2016.04.028
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