The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Nfib Promotes Metastasis through a Widespread Increase in Chromatin Accessibility
Open accessAbstract
SUMMARY Metastases are the main cause of cancer deaths, but the mechanisms underlying metastatic progression remain poorly understood. We isolated pure populations of cancer cells from primary tumors and metastases from a genetically engineered mouse model of human small cell lung cancer (SCLC) to investigate the mechanisms that drive the metastatic spread of this lethal cancer. Genome-wide characterization of chromatin accessibility revealed the opening of large numbers of distal regulatory elements across the genome during metastatic progression. These changes correlate with copy number amplification of the Nfib locus, and differentially accessible sites were highly enriched for Nfib transcription factor binding sites. Nfib is necessary and sufficient to increase chromatin accessibility at a large subset of the intergenic regions. Nfib promotes pro-metastatic neuronal gene expression programs and drives the metastatic ability of SCLC cells. The identification of widespread chromatin changes during SCLC progression reveals an unexpected global reprogramming during metastatic progression.
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The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity
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Self-citationThe pathogenesis of cancer metastasis: the ‘seed and soil’ hypothesis revisited
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Epigenetic expansion of VHL-HIF signal output drives multiorgan metastasis in renal cancer
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Klemm, S. L., Shipony, Z., & Greenleaf, W. J. (2019) · Nature Reviews Genetics · doi:10.1038/s41576-018-0089-8 · Cited by 1,793
Self-citationThe chromatin accessibility landscape of primary human cancers
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Metadata
- Authors
- Denny, S. K., Yang, D., Chuang, C.-H., Brady, J. J., Lim, J. S., Grüner, B. M., Chiou, S.-H., Schep, A. N., Baral, J., Hamard, C., Antoine, M., Wislez, M., Kong, C. S., Connolly, A. J., Park, K.-S., Sage, J., Greenleaf, W. J., & Winslow, M. M.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2016-07
- Volume
- 166
- Issue
- 2
- Pages
- 328-342
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2461903592
- Cited by
- 368
- References
- 8
- FWCI
- 16.70
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Denny, S. K., Yang, D., Chuang, C.-H., Brady, J. J., Lim, J. S., Grüner, B. M., Chiou, S.-H., Schep, A. N., Baral, J., Hamard, C., Antoine, M., Wislez, M., Kong, C. S., Connolly, A. J., Park, K.-S., Sage, J., Greenleaf, W. J., & Winslow, M. M. (2016). Nfib Promotes Metastasis through a Widespread Increase in Chromatin Accessibility. Cell. https://doi.org/10.1016/j.cell.2016.05.052
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