Massively parallel single-cell chromatin landscapes of human immune cell development and intratumoral T cell exhaustion

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TOX transcriptionally and epigenetically programs CD8+ T cell exhaustion

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Lineage-specific and single-cell chromatin accessibility charts human hematopoiesis and leukemia evolution

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Dysfunctional CD8 T cells form a proliferative, dynamically regulated compartment within human melanoma

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TOX reinforces the phenotype and longevity of exhausted T cells in chronic viral infection

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NR4A transcription factors limit CAR T cell function in solid tumours

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The Transcription Factor NFAT Promotes Exhaustion of Activated CD8 + T Cells

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Persistent Antigen and Germinal Center B Cells Sustain T Follicular Helper Cell Responses and Phenotype

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Re(de)fining the dendritic cell lineage

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Structured nucleosome fingerprints enable high-resolution mapping of chromatin architecture within regulatory regions

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The cis-regulatory dynamics of embryonic development at single-cell resolution

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Nfib Promotes Metastasis through a Widespread Increase in Chromatin Accessibility

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Developmental Fate and Cellular Maturity Encoded in Human Regulatory DNA Landscapes

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Coupled Single-Cell CRISPR Screening and Epigenomic Profiling Reveals Causal Gene Regulatory Networks

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Dynamic Changes in Chromatin Accessibility Occur in CD8 + T Cells Responding to Viral Infection

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Distinct progenitor lineages contribute to the heterogeneity of plasmacytoid dendritic cells

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Epigenetic landscapes reveal transcription factors that regulate CD8+ T cell differentiation

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A CD47-associated super-enhancer links pro-inflammatory signalling to CD47 upregulation in breast cancer

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GLI activation by atypical protein kinase C ι/λ regulates the growth of basal cell carcinomas

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Lineage-Determining Transcription Factor TCF-1 Initiates the Epigenetic Identity of T Cells

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Constitutive Glycolytic Metabolism Supports CD8+ T Cell Effector Memory Differentiation during Viral Infection

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Integrin-modulating therapy prevents fibrosis and autoimmunity in mouse models of scleroderma

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Clonal replacement of tumor-specific T cells following PD-1 blockadePreprint

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Microbiota-Induced TNF-like Ligand 1A Drives Group 3 Innate Lymphoid Cell-Mediated Barrier Protection and Intestinal T Cell Activation during Colitis

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Intertumoral Heterogeneity in SCLC Is Influenced by the Cell Type of Origin

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A sharp T-cell antigen receptor signaling threshold for T-cell proliferation

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Transcript-indexed ATAC-seq for precision immune profiling

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