The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Structural Basis of Zika Virus-Specific Antibody Protection
Open accessAbstract
SUMMARY Zika virus (ZIKV) infection during pregnancy has emerged as a global public health problem because of its ability to cause severe congenital disease. Here, we developed six mouse monoclonal antibodies (mAbs) against ZIKV including four (ZV-48, ZV-54, ZV-64, and ZV-67) that were ZIKV-specific and neutralized infection of African, Asian, and American strains to varying degrees. X-ray crystallographic and competition binding analyses of Fab fragments and scFvs defined three spatially distinct epitopes in DIII of the envelope protein corresponding to the lateral ridge (ZV-54 and ZV-67), C–C′ loop (ZV-48 and ZV-64), and ABDE sheet (ZV-2) regions. In vivo passive transfer studies revealed protective activity of DIII-lateral ridge specific neutralizing mAbs in a mouse model of ZIKV infection. Our results suggest that DIII is targeted by multiple type-specific antibodies with distinct neutralizing activity, which provides a path for developing prophylactic antibodies for use in pregnancy or designing epitope-specific vaccines against ZIKV.
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Cites
The Brazilian Zika virus strain causes birth defects in experimental models
Cugola, F. R., Fernandes, I. R., Russo, F. B., Freitas, B. C., Dias, J. L. M., Guimarães, K. P., Benazzato, C., Almeida, N., Pignatari, G. C., Romero, S., et al. (2016) · Nature · doi:10.1038/nature18296 · Cited by 1,326
Zika Virus Disrupts Neural Progenitor Development and Leads to Microcephaly in Mice
Li, C., Xu, D., Ye, Q., Hong, S., Jiang, Y., Liu, X., Zhang, N., Shi, L., Qin, C.-F., & Xu, Z. (2016) · Cell Stem Cell · doi:10.1016/j.stem.2016.04.017 · Cited by 749
Proof of principle for epitope-focused vaccine design
Correia, B. E., Bates, J. T., Loomis, R. J., Baneyx, G., Carrico, C., Jardine, J. G., Rupert, P., Correnti, C., Kalyuzhniy, O., Vittal, V., et al. (2014) · Nature · doi:10.1038/nature12966 · Cited by 555
Characterization of a Novel Murine Model to Study Zika Virus
Rossi, S. L., Tesh, R. B., Azar, S. R., Muruato, A. E., Hanley, K. A., Auguste, A. J., Langsjoen, R. M., Paessler, S., Vasilakis, N., & Weaver, S. C. (2016) · The American Society of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.16-0111 · Cited by 458
Cited by
Modified mRNA vaccines protect against zika virus infection
Richner, J. M., Himansu, S., Dowd, K. A., Butler, S. L., Salazar, V., Fox, J. M., Julander, J. G., Tang, W. W., Shresta, S., Pierson, T. C., et al. (2017) · Cell · doi:10.1016/j.cell.2017.02.017 · Cited by 909
Self-citationZika Virus Pathogenesis and Tissue Tropism
Miner, J. J., & Diamond, M. S. (2017) · Cell Host & Microbe · doi:10.1016/j.chom.2017.01.004 · Cited by 417
Self-citationRapid development of a DNA vaccine for Zika virus
Dowd, K. A., Ko, S.-Y., Morabito, K. M., Yang, E. S., Pelc, R. S., DeMaso, C. R., Castilho, L. R., Abbink, P., Boyd, M., Nityanandam, R., et al. (2016) · Science · doi:10.1126/science.aai9137 · Cited by 396
Self-citationAnimal Models of Zika Virus Infection, Pathogenesis, and Immunity
Morrison, T. E., & Diamond, M. S. (2017) · Journal of Virology · doi:10.1128/jvi.00009-17 · Cited by 275
Self-citationVaccine Mediated Protection Against Zika Virus-Induced Congenital Disease
Richner, J. M., Jagger, B. W., Shan, C., Fontes, C. R., Dowd, K. A., Cao, B., Himansu, S., Caine, E. A., Nunes, B. T. D., Medeiros, D. B. A., et al. (2017) · Cell · doi:10.1016/j.cell.2017.06.040 · Cited by 267
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Metadata
- Authors
- Zhao, H., Fernandez, E., Dowd, K. A., Speer, S. D., Platt, D. J., Gorman, M. J., Govero, J., Nelson, C. A., Pierson, T. C., Diamond, M. S., & Fremont, D. H.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2016-08
- Volume
- 166
- Issue
- 4
- Pages
- 1016-1027
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2493146871
- Cited by
- 375
- References
- 4
- FWCI
- 61.67
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Zhao, H., Fernandez, E., Dowd, K. A., Speer, S. D., Platt, D. J., Gorman, M. J., Govero, J., Nelson, C. A., Pierson, T. C., Diamond, M. S., & Fremont, D. H. (2016). Structural Basis of Zika Virus-Specific Antibody Protection. Cell. https://doi.org/10.1016/j.cell.2016.07.020
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
