The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Structure of a Complete Mediator-RNA Polymerase II Pre-Initiation Complex
Open accessAbstract
SUMMARY A complete, 52-protein, 2.5 million Dalton, Mediator-RNA polymerase II pre-initiation complex (Med-PIC) was assembled and analyzed by cryo-electron microscopy and by chemical cross-linking and mass spectrometry. The resulting complete Med-PIC structure reveals two components of functional significance, absent from previous structures, a protein kinase complex and the Mediator-activator interaction region. It thereby shows how the kinase and its target, the C-terminal domain of the polymerase, control Med-PIC interaction and transcription.
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The Phyre2 web portal for protein modeling, prediction and analysis
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RELION: Implementation of a Bayesian approach to cryo-EM structure determination
Scheres, S. H. W. (2012) · Journal of Structural Biology · doi:10.1016/j.jsb.2012.09.006 · Cited by 5,446
A comprehensive analysis of protein–protein interactions in Saccharomyces cerevisiae
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A comprehensive two-hybrid analysis to explore the yeast protein interactome
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A mediator required for activation of RNA polymerase II transcription in vitro
Flanagan, P. M., Kelleher, R. J., Sayre, M. H., Tschochner, H., & Kornberg, R. D. (1991) · Nature · doi:10.1038/350436a0 · Cited by 386 · cited 1×
“Mediator, an assembly of more than 20 proteins, is required for the regulation ofRNApolymerase II (pol II) transcription (Flanagan et al., 1991; Kim et al., 1994; Thompson and Young, 1995; reviewed inKornberg, 2005).”
Self-citationSubunit Architecture and Functional Modular Rearrangements of the Transcriptional Mediator Complex
Tsai, K.-L., Tomomori-Sato, C., Sato, S., Conaway, R. C., Conaway, J. W., & Asturias, F. J. (2014) · Cell · doi:10.1016/j.cell.2014.05.015 · Cited by 218
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Cited by
Mediator and RNA polymerase II clusters associate in transcription-dependent condensates
Cho, W.-K., Spille, J.-H., Hecht, M., Lee, C., Li, C., Grube, V., & Cisse, I. I. (2018) · Science · doi:10.1126/science.aar4199 · Cited by 1,403
The code and beyond: transcription regulation by the RNA polymerase II carboxy-terminal domain
Harlen, K. M., & Churchman, L. S. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.10 · Cited by 499
Cross-Linking Mass Spectrometry: An Emerging Technology for Interactomics and Structural Biology
Yu, C., & Huang, L. (2018) · Analytical Chemistry · doi:10.1021/acs.analchem.7b04431 · Cited by 353
Introns as Gene Regulators: A Brick on the Accelerator
Rose, A. B. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2018.00672 · Cited by 258
El Khattabi, L., Zhao, H., Kalchschmidt, J., Young, N., Jung, S., Van Blerkom, P., Kieffer-Kwon, P., Kieffer-Kwon, K.-R., Park, S., Wang, X., et al. (2019) · Cell · doi:10.1016/j.cell.2019.07.011 · Cited by 244
Metadata
- Authors
- Robinson, P. J., Trnka, M. J., Bushnell, D. A., Davis, R. E., Mattei, P.-J., Burlingame, A. L., & Kornberg, R. D.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2016-09
- Volume
- 166
- Issue
- 6
- Pages
- 1411-1422.e16
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2515162953
- Cited by
- 240
- References
- 7
- FWCI
- 16.25
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Robinson, P. J., Trnka, M. J., Bushnell, D. A., Davis, R. E., Mattei, P.-J., Burlingame, A. L., & Kornberg, R. D. (2016). Structure of a Complete Mediator-RNA Polymerase II Pre-Initiation Complex. Cell. https://doi.org/10.1016/j.cell.2016.08.050
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