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Structural basis of the human transcriptional Mediator regulated by its dissociable kinase module

Chao, T., Chen, S.-F., Kim, H. J., Tang, H.-C., Tseng, H.-C., Xu, A., Palao, L., Khadka, S., Li, T., Huang, M.-F., et al. (2024) · Molecular Cell · doi:10.1016/j.molcel.2024.09.001 · Cited by 31 · see citing works

Super enhancers—Functional cores under the 3D genome

Zhang, J., Yue, W., Zhou, Y., Liao, M., Chen, X., & Hua, J. (2020) · Cell Proliferation · doi:10.1111/cpr.12970 · Cited by 25 · see citing works

Distinct roles for CKM–Mediator in controlling Polycomb-dependent chromosomal interactions and priming genes for induction

Dimitrova, E., Feldmann, A., van der Weide, R. H., Flach, K. D., Lastuvkova, A., de Wit, E., & Klose, R. J. (2022) · Nature Structural & Molecular Biology · doi:10.1038/s41594-022-00840-5 · Cited by 26 · see citing works

The dynamics of three-dimensional chromatin organization and phase separation in cell fate transitions and diseases

Ling, X., Liu, X., Jiang, S., Fan, L., & Ding, J. (2022) · Cell Regeneration · doi:10.1186/s13619-022-00145-4 · Cited by 29 · see citing works

MLL-AF4 cooperates with PAF1 and FACT to drive high-density enhancer interactions in leukemia

Crump, N. T., Smith, A., Godfrey, L., Dopico-Fernandez, A. M., Denny, N., Harman, J. R., Hamley, J. C., Jackson, N., Chahrour, C., Riva, S. G., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-40981-9 · Cited by 27 · see citing works

The SAGA complex regulates early steps in transcription via its deubiquitylase module subunit USP22

Stanek, T., Gennaro, V. J., Tracewell, M. A., Marcantonio, D. D., Pauley, K., Butt, S., McNair, C., Wang, F., Kossenkov, A., Knudsen, K., et al. (2021) · EMBO Journal · doi:10.15252/embj.2019102509 · Cited by 22 · see citing works

Targeted protein degradation reveals RNA Pol II heterogeneity and functional diversity

Li, Y., Huang, J. S., Zhu, J., Bao, L., Wang, H., Jiang, Y., Tian, K., Wang, R., Zheng, H., Duan, W., et al. (2022) · Molecular Cell · doi:10.1016/j.molcel.2022.08.023 · Cited by 26 · see citing works

Epigenetic memory contributing to the pathogenesis of AKI-to-CKD transition

Tanemoto, F., Nangaku, M., & Mimura, I. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.1003227 · Cited by 26 · see citing works

Engineered MED12 mutations drive leiomyoma-like transcriptional and metabolic programs by altering the 3D genome compartmentalization

Buyukcelebi, K., Chen, X., Abdula, F., Elkafas, H., Duval, A. J., Öztürk, H., Seker-Polat, F., Jin, Q., Yin, P., Yue, F., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-39684-y · Cited by 26 · see citing works

The Plant Mediator Complex in the Initiation of Transcription by RNA Polymerase II

Freytes, S. N., Gobbini, M. L., & Cerdán, P. D. (2024) · Annual Review of Plant Biology · doi:10.1146/annurev-arplant-070623-114005 · Cited by 25 · see citing works

Norstictic Acid Is a Selective Allosteric Transcriptional Regulator

Garlick, J. M., Sturlis, S. M., Bruno, P. A., Yates, J. A., Peiffer, A. L., Liu, Y., Goo, L., Bao, L., Salle, S. N. D., Tamayo‐Castillo, G., et al. (2021) · Journal of the American Chemical Society · doi:10.1021/jacs.1c03258 · Cited by 25 · see citing works

3D chromatin architecture, BRD4, and Mediator have distinct roles in regulating genome-wide transcriptional bursting and gene network

Trzaskoma, P., Jung, S., Pękowska, A., Bohrer, C. H., Wang, X., Naz, F., Dell’Orso, S., du Bois, W., Olivera, A., Vartak, S. V., et al. (2024) · Science Advances · doi:10.1126/sciadv.adl4893 · Cited by 23 · see citing works

Postmitotic differentiation of human monocytes requires cohesin-structured chromatin

Minderjahn, J., Fischer, A. H., Maier, K., Mendes, K., Nuetzel, M., Raithel, J., Stanewsky, H., Ackermann, U., Månsson, R., Gebhard, C., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-31892-2 · Cited by 24 · see citing works

Comparison of transcriptional initiation by RNA polymerase II across eukaryotic species

Petrenko, N., & Struhl, K. (2021) · eLife · doi:10.7554/elife.67964 · Cited by 25 · see citing works

Yeast Mediator facilitates transcription initiation at most promoters via a Tail-independent mechanism

Warfield, L., Donczew, R., Mahendrawada, L., & Hahn, S. (2022) · Molecular Cell · doi:10.1016/j.molcel.2022.09.016 · Cited by 23 · see citing works

Clock-controlled rhythmic transcription: is the clock enough and how does it work?

Beytebiere, J. R., Greenwell, B. J., Sahasrabudhe, A., & Menet, J. S. (2019) · Transcription · doi:10.1080/21541264.2019.1673636 · Cited by 23 · see citing works

Mechanism and regulation of class switch recombination by IgH transcriptional control elements

Oudinet, C., Braikia, F.-Z., Dauba, A., & Khamlichi, A. A. (2020) · Advances in immunology · doi:10.1016/bs.ai.2020.06.003 · Cited by 22 · see citing works

CDK8 and CDK19 act redundantly to control the CFTR pathway in the intestinal epithelium

Prieto, S., Dubra, G., Camasses, A., Simboeck, E., Aznar, A. B., Begon‐Pescia, C., Pirot, N., Gerbe, F., Angevin, L., Jay, P., et al. (2022) · EMBO Reports · doi:10.15252/embr.202154261 · Cited by 22 · see citing works

Acetyl-CoA production by Mediator-bound 2-ketoacid dehydrogenases boosts de novo histone acetylation and is regulated by nitric oxide

Russo, M., Gualdrini, F., Vallelonga, V., Prosperini, E., Noberini, R., Pedretti, S., Borriero, C., Chiaro, P. D., Polletti, S., Imperato, G., et al. (2024) · Molecular Cell · doi:10.1016/j.molcel.2023.12.033 · Cited by 21 · see citing works

Decoding the organization, dynamics, and function of the 4D genome

Aboelnour, E., & Bonev, B. (2021) · Developmental Cell · doi:10.1016/j.devcel.2021.04.023 · Cited by 21 · see citing works

Mammalian Mediator as a Functional Link between Enhancers and Promoters

Soutourina, J. (2019) · Cell · doi:10.1016/j.cell.2019.07.040 · Cited by 15 · see citing works

Deciphering mediator's function and structure in mammalian cells

Khattabi, L. E., Kalchschmidt, J., Kieffer-Kwon, P., Krebs, J., Jung, S. K., Young, N. R., Kieffer-Kwon, K.-R., Chauss, D., Tripathi, S. K., Pruett, N. D., et al. (2018) · Morphologie · doi:10.1016/j.morpho.2018.07.115

Structure of the Mammalian MediatorPreprint

Zhao, H., Young, N., Kalchschmidt, J. S., Lieberman, J., Khattabi, L. E., Casellas, R., & Asturias, F. (2020) · bioRxiv · doi:10.1101/2020.10.05.326918

Molecular electron microscopy analysis of the mammalian mediator complex

Young, N. E. (2021) · doi:10.25677/b6sg-9666

Mediator Comes Out from the Shadows

Conaway, R. C., & Conaway, J. W. (2009) · Structure · doi:10.1016/j.str.2009.03.003 · Cited by 2 · see citing works